TC2 more effective in all the biomarker signatures
| signature | var | Other | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| all | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| all | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| AR- & TP53- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| AR- & TP53- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| AR- & TP53- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| HRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| HRD+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| HRD+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| TP53+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| TP53+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| TEfus+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| TEfus+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| PI3K+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| PI3K+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| PI3K+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| —– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| —-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| —+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| —++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+— | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| -+— | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+–+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| -+–+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+-+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| -+-+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+-++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| -+-++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -++– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| -++– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -++-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| -++-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| -+++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -++++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| -++++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +—- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +—- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +—- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +—+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +—+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +—+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +–+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +–+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +–+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +–++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +–++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +–++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-+– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-+– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-+-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-+-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-+++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-+++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++— | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| ++— | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++–+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| ++–+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++-+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| ++-+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++-++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| ++-++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +++– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +++– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +++-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +++-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| ++++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +++++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +++++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
|
|
|
|
|
|
| char | overall | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| err_sign | 0.544 | 0.02 | 0.524 | 0.004 | 0.016 | 0.01 |
| err_type | 0.048 | 0.02 | 0.000 | 0.004 | 0.016 | 0.01 |
| pow_sign | 0.450 | 0.00 | 0.450 | 0.000 | 0.000 | 0.00 |
| pow_type | 0.974 | 0.00 | 0.974 | 0.000 | 0.000 | 0.00 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| all | graduation | 0 | 3 | 225 | 0 | 2 | 1 |
| all | futility | 0 | 37 | 0 | 17 | 23 | 26 |
| all | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| all | n | 409 (373, 444) | 139 (84, 214) | 116 (33, 226) | 154 (92, 230) | 150 (94, 226) | 144 (84, 228) |
| all | n_unique | 382 (349, 414) | 128 (78, 202) | 106 (30, 215) | 141 (84, 214) | 137 (86, 213) | 133 (77, 211) |
| all | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (6, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| all | time_stop | NA (NA, NA) | 14 (3, 31) | 10 (5, 28) | 28 (11, 35) | 24 (8, 35) | 23 (8, 34) |
| all | post_p | NA (NA, NA) | 0 (0, 0.02) | 1 (1, 1) | 0 (0, 0.01) | 0 (0, 0.01) | 0 (0, 0.01) |
| all | rate | 0.076 (0.071, 0.083) | 0.114 (0.1, 0.131) | 0.038 (0.032, 0.045) | 0.114 (0.101, 0.129) | 0.114 (0.102, 0.128) | 0.114 (0.101, 0.13) |
| AR- & TP53- | graduation | 0 | 4 | 325 | 2 | 4 | 2 |
| AR- & TP53- | futility | 0 | 250 | 0 | 232 | 213 | 245 |
| AR- & TP53- | max_n | 0 | 39 | 71 | 78 | 65 | 61 |
| AR- & TP53- | n | 246 (215, 272) | 68 (27, 148) | 34 (17, 152) | 78 (32, 152) | 80 (29, 151) | 72 (30, 151) |
| AR- & TP53- | n_unique | 231 (200, 256) | 63 (26, 138) | 31 (16, 144) | 73 (29, 143) | 73 (26, 143) | 66 (27, 142) |
| AR- & TP53- | time_trial | 36 (36, 36) | 35 (9, 36) | 18 (8, 36) | 36 (15, 36) | 36 (15, 36) | 36 (15, 36) |
| AR- & TP53- | time_stop | NA (NA, NA) | 18 (7, 32) | 11 (8, 25) | 22 (12, 33) | 21 (12, 32) | 23 (13, 32) |
| AR- & TP53- | post_p | NA (NA, NA) | 0.01 (0, 0.09) | 1 (0.98, 1) | 0.01 (0, 0.09) | 0.01 (0, 0.11) | 0.01 (0, 0.09) |
| AR- & TP53- | rate | 0.076 (0.069, 0.084) | 0.116 (0.098, 0.141) | 0.038 (0.029, 0.048) | 0.115 (0.098, 0.142) | 0.115 (0.098, 0.14) | 0.115 (0.098, 0.146) |
| HRD+ | graduation | 0 | 2 | 40 | 0 | 2 | 1 |
| HRD+ | futility | 0 | 53 | 0 | 96 | 102 | 62 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 62 (49, 75) | 25 (8, 44) | 13 (2, 30) | 29 (18, 47) | 29 (19, 50) | 25 (13, 44) |
| HRD+ | n_unique | 58 (45, 69) | 22 (8, 41) | 12 (2, 27) | 27 (17, 44) | 27 (18, 46) | 23 (12, 41) |
| HRD+ | time_trial | 36 (36, 36) | 36 (35, 36) | 36 (36, 36) | 36 (27, 36) | 36 (29, 36) | 36 (35, 36) |
| HRD+ | time_stop | NA (NA, NA) | 31 (23, 35) | 28 (21, 35) | 27 (20, 35) | 30 (21, 34) | 31 (23, 36) |
| HRD+ | post_p | NA (NA, NA) | 0.14 (0.02, 0.49) | 0.97 (0.66, 1) | 0.1 (0.01, 0.37) | 0.1 (0.01, 0.36) | 0.12 (0.01, 0.45) |
| HRD+ | rate | 0.076 (0.063, 0.094) | 0.116 (0.086, 0.17) | 0.038 (0.022, 0.065) | 0.115 (0.092, 0.148) | 0.115 (0.091, 0.15) | 0.113 (0.089, 0.162) |
| TP53+ | graduation | 0 | 0 | 219 | 0 | 0 | 0 |
| TP53+ | futility | 0 | 182 | 0 | 156 | 165 | 177 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| TP53+ | n | 135 (119, 156) | 53 (26, 85) | 38 (13, 103) | 54 (28, 87) | 53 (28, 85) | 53 (26, 85) |
| TP53+ | n_unique | 126 (109, 144) | 49 (24, 78) | 34 (12, 97) | 48 (26, 80) | 48 (26, 77) | 48 (25, 79) |
| TP53+ | time_trial | 36 (36, 36) | 36 (19, 36) | 36 (14, 36) | 36 (20, 36) | 36 (21, 36) | 36 (17, 36) |
| TP53+ | time_stop | NA (NA, NA) | 24 (15, 34) | 18 (12, 29) | 24 (16, 32) | 25 (16, 34) | 23 (13, 34) |
| TP53+ | post_p | NA (NA, NA) | 0.03 (0, 0.23) | 1 (0.98, 1) | 0.03 (0, 0.21) | 0.03 (0, 0.21) | 0.03 (0, 0.19) |
| TP53+ | rate | 0.076 (0.067, 0.089) | 0.114 (0.095, 0.146) | 0.038 (0.028, 0.048) | 0.114 (0.095, 0.144) | 0.116 (0.096, 0.146) | 0.116 (0.095, 0.144) |
| TEfus+ | graduation | 0 | 1 | 146 | 0 | 0 | 1 |
| TEfus+ | futility | 0 | 78 | 0 | 72 | 69 | 92 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 126 (109, 142) | 52 (28, 79) | 36 (12, 76) | 54 (32, 81) | 55 (33, 78) | 53 (28, 79) |
| TEfus+ | n_unique | 116 (100, 133) | 47 (25, 73) | 34 (11, 70) | 50 (29, 74) | 50 (30, 72) | 49 (26, 72) |
| TEfus+ | time_trial | 36 (36, 36) | 36 (29, 36) | 36 (16, 36) | 36 (30, 36) | 36 (30, 36) | 36 (26, 36) |
| TEfus+ | time_stop | NA (NA, NA) | 27 (17, 35) | 19 (12, 31) | 26 (17, 34) | 26 (16, 35) | 24 (17, 35) |
| TEfus+ | post_p | NA (NA, NA) | 0.03 (0, 0.25) | 1 (0.96, 1) | 0.03 (0, 0.19) | 0.03 (0, 0.21) | 0.03 (0, 0.25) |
| TEfus+ | rate | 0.077 (0.066, 0.089) | 0.115 (0.094, 0.145) | 0.038 (0.028, 0.05) | 0.114 (0.097, 0.143) | 0.116 (0.096, 0.142) | 0.116 (0.094, 0.142) |
| PI3K+ | graduation | 0 | 0 | 173 | 0 | 0 | 0 |
| PI3K+ | futility | 0 | 125 | 0 | 113 | 122 | 172 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| PI3K+ | n | 132 (114, 151) | 52 (26, 85) | 28 (9, 70) | 54 (30, 82) | 53 (29, 84) | 54 (28, 86) |
| PI3K+ | n_unique | 123 (106, 141) | 47 (24, 78) | 26 (8, 65) | 50 (28, 78) | 48 (26, 78) | 50 (26, 80) |
| PI3K+ | time_trial | 36 (36, 36) | 36 (22, 36) | 36 (17, 36) | 36 (24, 36) | 36 (23, 36) | 36 (15, 36) |
| PI3K+ | time_stop | NA (NA, NA) | 25 (16, 35) | 20 (14, 31) | 26 (17, 34) | 25 (17, 35) | 19 (10, 33) |
| PI3K+ | post_p | NA (NA, NA) | 0.03 (0, 0.23) | 1 (0.92, 1) | 0.03 (0, 0.2) | 0.03 (0, 0.2) | 0.03 (0, 0.19) |
| PI3K+ | rate | 0.077 (0.066, 0.088) | 0.115 (0.095, 0.147) | 0.038 (0.026, 0.052) | 0.115 (0.094, 0.143) | 0.116 (0.096, 0.144) | 0.115 (0.095, 0.14) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| —– | graduation | 0 | 7 | 423 | 2 | 6 | 3 |
| —– | futility | 0 | 264 | 0 | 233 | 218 | 249 |
| —– | max_n | 0 | 39 | 71 | 78 | 65 | 61 |
| —– | n | 145 (123, 165) | 26 (15, 85) | 23 (12, 106) | 31 (10, 98) | 29 (8, 97) | 28 (8, 93) |
| —– | n_unique | 138 (117, 157) | 25 (15, 81) | 22 (11, 102) | 29 (9, 94) | 26 (7, 90) | 26 (7, 90) |
| —– | post_p | NA (NA, NA) | 0.05 (0, 0.23) | 1 (0.92, 1) | 0.06 (0, 0.28) | 0.06 (0, 0.34) | 0.06 (0, 0.29) |
| —– | rate | 0.076 (0.067, 0.088) | 0.118 (0.095, 0.156) | 0.039 (0.028, 0.052) | 0.116 (0.094, 0.162) | 0.119 (0.092, 0.172) | 0.119 (0.094, 0.193) |
| —-+ | graduation | 0 | 7 | 431 | 2 | 6 | 3 |
| —-+ | futility | 0 | 299 | 0 | 265 | 252 | 297 |
| —-+ | max_n | 0 | 37 | 68 | 76 | 64 | 59 |
| —-+ | n | 32 (24, 41) | 9 (3, 26) | 4 (1, 15) | 9 (3, 26) | 10 (3, 26) | 10 (5, 27) |
| —-+ | n_unique | 30 (22, 39) | 8 (3, 24) | 3 (0, 13) | 8 (3, 24) | 9 (3, 25) | 9 (4, 25) |
| —-+ | post_p | NA (NA, NA) | 0.23 (0.08, 0.55) | 0.86 (0.49, 0.99) | 0.23 (0.07, 0.52) | 0.25 (0.08, 0.58) | 0.23 (0.07, 0.56) |
| —-+ | rate | 0.076 (0.058, 0.101) | 0.127 (0.082, 0.248) | 0.038 (0.014, 0.089) | 0.125 (0.084, 0.268) | 0.123 (0.082, 0.296) | 0.12 (0.082, 0.227) |
| —+- | graduation | 0 | 8 | 425 | 2 | 6 | 4 |
| —+- | futility | 0 | 278 | 0 | 245 | 229 | 259 |
| —+- | max_n | 0 | 38 | 71 | 77 | 64 | 60 |
| —+- | n | 5 (2, 9) | 2 (0, 6) | 1 (0, 4) | 2 (0, 6) | 2 (0, 6) | 2 (0, 6) |
| —+- | n_unique | 5 (2, 9) | 2 (0, 5) | 1 (0, 3) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) |
| —+- | post_p | NA (NA, NA) | 0.43 (0.28, 0.66) | 0.65 (0.43, 0.87) | 0.43 (0.26, 0.67) | 0.43 (0.25, 0.66) | 0.42 (0.27, 0.66) |
| —+- | rate | 0.081 (0.035, 0.186) | 0.129 (0.06, 0.396) | 0.047 (0, 0.145) | 0.129 (0.054, 0.358) | 0.13 (0.054, 0.491) | 0.135 (0.052, 0.462) |
| —++ | graduation | 0 | 8 | 432 | 2 | 6 | 4 |
| —++ | futility | 0 | 304 | 0 | 272 | 258 | 302 |
| —++ | max_n | 0 | 36 | 68 | 75 | 63 | 58 |
| —++ | n | 14 (9, 20) | 5 (1, 13) | 2 (0, 6) | 5 (1, 13) | 5 (1, 13) | 5 (2, 13) |
| —++ | n_unique | 13 (8, 19) | 4 (1, 12) | 2 (0, 6) | 5 (1, 12) | 4 (1, 12) | 5 (2, 12) |
| —++ | post_p | NA (NA, NA) | 0.34 (0.16, 0.64) | 0.76 (0.45, 0.94) | 0.35 (0.16, 0.63) | 0.35 (0.15, 0.68) | 0.32 (0.15, 0.59) |
| —++ | rate | 0.078 (0.046, 0.119) | 0.13 (0.075, 0.357) | 0.042 (0, 0.124) | 0.135 (0.072, 0.384) | 0.127 (0.07, 0.342) | 0.132 (0.077, 0.32) |
| –+– | graduation | 0 | 3 | 363 | 0 | 2 | 1 |
| –+– | futility | 0 | 202 | 0 | 161 | 170 | 183 |
| –+– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –+– | n | 29 (21, 37) | 10 (4, 25) | 8 (2, 28) | 9 (4, 22) | 9 (4, 25) | 8 (3, 22) |
| –+– | n_unique | 27 (19, 35) | 9 (4, 23) | 7 (2, 26) | 8 (3, 20) | 8 (3, 23) | 7 (3, 21) |
| –+– | post_p | NA (NA, NA) | 0.23 (0.08, 0.62) | 0.92 (0.62, 1) | 0.26 (0.09, 0.59) | 0.25 (0.08, 0.58) | 0.24 (0.08, 0.57) |
| –+– | rate | 0.078 (0.055, 0.109) | 0.12 (0.079, 0.223) | 0.039 (0.018, 0.071) | 0.123 (0.079, 0.254) | 0.123 (0.08, 0.243) | 0.127 (0.08, 0.249) |
| –+-+ | graduation | 0 | 3 | 408 | 0 | 2 | 1 |
| –+-+ | futility | 0 | 247 | 0 | 206 | 219 | 255 |
| –+-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –+-+ | n | 28 (20, 36) | 8 (3, 23) | 6 (1, 21) | 9 (4, 24) | 8 (4, 23) | 9 (4, 22) |
| –+-+ | n_unique | 26 (18, 34) | 7 (3, 22) | 5 (1, 20) | 8 (3, 22) | 8 (3, 22) | 8 (3, 20) |
| –+-+ | post_p | NA (NA, NA) | 0.23 (0.09, 0.58) | 0.88 (0.47, 0.99) | 0.26 (0.09, 0.59) | 0.26 (0.09, 0.58) | 0.25 (0.09, 0.61) |
| –+-+ | rate | 0.076 (0.057, 0.105) | 0.129 (0.081, 0.302) | 0.04 (0.018, 0.094) | 0.121 (0.077, 0.266) | 0.126 (0.08, 0.258) | 0.123 (0.08, 0.23) |
| –++- | graduation | 0 | 4 | 389 | 0 | 2 | 2 |
| –++- | futility | 0 | 229 | 0 | 186 | 194 | 220 |
| –++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –++- | n | 8 (4, 12) | 3 (1, 7) | 3 (0, 7) | 3 (1, 7) | 3 (1, 6) | 3 (1, 7) |
| –++- | n_unique | 7 (4, 11) | 3 (1, 6) | 2 (0, 7) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) |
| –++- | post_p | NA (NA, NA) | 0.38 (0.22, 0.67) | 0.72 (0.4, 0.93) | 0.4 (0.21, 0.64) | 0.41 (0.22, 0.65) | 0.39 (0.23, 0.64) |
| –++- | rate | 0.077 (0.038, 0.145) | 0.13 (0.055, 0.384) | 0.042 (0.012, 0.131) | 0.134 (0.057, 0.453) | 0.13 (0.06, 0.38) | 0.13 (0.058, 0.421) |
| –+++ | graduation | 0 | 4 | 421 | 0 | 2 | 2 |
| –+++ | futility | 0 | 263 | 0 | 223 | 233 | 276 |
| –+++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –+++ | n | 21 (15, 28) | 7 (2, 17) | 5 (1, 16) | 7 (2, 18) | 6 (2, 16) | 7 (3, 17) |
| –+++ | n_unique | 20 (13, 27) | 6 (2, 16) | 4 (1, 15) | 6 (2, 17) | 6 (2, 15) | 6 (3, 16) |
| –+++ | post_p | NA (NA, NA) | 0.29 (0.11, 0.61) | 0.87 (0.47, 0.99) | 0.31 (0.12, 0.64) | 0.3 (0.12, 0.57) | 0.29 (0.13, 0.63) |
| –+++ | rate | 0.077 (0.055, 0.112) | 0.129 (0.076, 0.293) | 0.039 (0.017, 0.095) | 0.128 (0.074, 0.304) | 0.128 (0.077, 0.317) | 0.122 (0.076, 0.243) |
| -+— | graduation | 0 | 8 | 429 | 2 | 7 | 4 |
| -+— | futility | 0 | 286 | 0 | 271 | 270 | 280 |
| -+— | max_n | 0 | 36 | 66 | 76 | 62 | 57 |
| -+— | n | 28 (19, 36) | 8 (1, 23) | 3 (0, 15) | 10 (4, 21) | 10 (5, 24) | 9 (3, 23) |
| -+— | n_unique | 26 (17, 33) | 7 (1, 21) | 3 (0, 14) | 9 (4, 20) | 9 (4, 23) | 8 (3, 21) |
| -+— | post_p | NA (NA, NA) | 0.28 (0.11, 0.55) | 0.84 (0.52, 0.99) | 0.26 (0.08, 0.56) | 0.24 (0.08, 0.57) | 0.26 (0.08, 0.59) |
| -+— | rate | 0.076 (0.056, 0.105) | 0.125 (0.084, 0.286) | 0.041 (0.015, 0.085) | 0.12 (0.082, 0.23) | 0.12 (0.081, 0.222) | 0.125 (0.081, 0.268) |
| -+–+ | graduation | 0 | 8 | 437 | 2 | 7 | 3 |
| -+–+ | futility | 0 | 315 | 0 | 296 | 298 | 317 |
| -+–+ | max_n | 0 | 34 | 63 | 74 | 61 | 57 |
| -+–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+–+ | post_p | NA (NA, NA) | 0.48 (0.48, 0.51) | 0.6 (0.6, 0.6) | 0.53 (0.53, 0.53) | 0.45 (0.43, 0.47) | 0.51 (0.45, 0.56) |
| -+–+ | rate | 0.211 (0, 1.259) | 0.15 (0, 10.787) | 0 (0, 0.048) | 0.132 (0, 3.66) | 0.171 (0, 0.36) | 0.065 (0, 0.471) |
| -+-+- | graduation | 0 | 9 | 430 | 2 | 7 | 5 |
| -+-+- | futility | 0 | 298 | 0 | 281 | 277 | 287 |
| -+-+- | max_n | 0 | 35 | 66 | 75 | 61 | 56 |
| -+-+- | n | 13 (8, 18) | 4 (0, 12) | 1 (0, 5) | 6 (2, 12) | 5 (2, 12) | 5 (1, 12) |
| -+-+- | n_unique | 12 (7, 17) | 4 (0, 11) | 1 (0, 5) | 5 (2, 11) | 5 (2, 12) | 4 (1, 11) |
| -+-+- | post_p | NA (NA, NA) | 0.37 (0.19, 0.69) | 0.75 (0.39, 0.93) | 0.33 (0.14, 0.62) | 0.36 (0.17, 0.66) | 0.36 (0.19, 0.66) |
| -+-+- | rate | 0.079 (0.047, 0.121) | 0.125 (0.059, 0.318) | 0.04 (0, 0.157) | 0.132 (0.075, 0.322) | 0.123 (0.068, 0.286) | 0.129 (0.07, 0.383) |
| -+-++ | graduation | 0 | 9 | 437 | 2 | 7 | 4 |
| -+-++ | futility | 0 | 320 | 0 | 302 | 301 | 320 |
| -+-++ | max_n | 0 | 33 | 63 | 73 | 60 | 56 |
| -+-++ | n | 5 (2, 9) | 2 (0, 6) | 0 (0, 3) | 2 (1, 6) | 3 (1, 6) | 2 (0, 5) |
| -+-++ | n_unique | 5 (2, 9) | 1 (0, 5) | 0 (0, 2) | 2 (0, 6) | 2 (0, 6) | 2 (0, 5) |
| -+-++ | post_p | NA (NA, NA) | 0.43 (0.27, 0.68) | 0.63 (0.42, 0.82) | 0.42 (0.25, 0.64) | 0.42 (0.26, 0.64) | 0.43 (0.28, 0.66) |
| -+-++ | rate | 0.076 (0.035, 0.167) | 0.127 (0.05, 0.433) | 0.048 (0, 0.185) | 0.141 (0.058, 0.484) | 0.131 (0.056, 0.466) | 0.129 (0.05, 0.438) |
| -++– | graduation | 0 | 5 | 377 | 0 | 4 | 2 |
| -++– | futility | 0 | 234 | 0 | 219 | 228 | 215 |
| -++– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -++– | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -++– | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -++– | post_p | NA (NA, NA) | 0.5 (0.5, 0.5) | 0.54 (0.54, 0.54) | 0.53 (0.51, 0.55) | 0.56 (0.56, 0.56) | NA (NA, NA) |
| -++– | rate | 0.234 (0, 0.66) | 0.174 (0, 0.992) | 0.041 (0, 0.155) | 0.167 (0, 1.294) | 0.148 (0, 0.896) | 0.237 (0, 1.533) |
| -++-+ | graduation | 0 | 5 | 420 | 0 | 4 | 1 |
| -++-+ | futility | 0 | 267 | 0 | 255 | 266 | 273 |
| -++-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -++-+ | n | 3 (1, 6) | 1 (0, 4) | 0 (0, 3) | 2 (0, 4) | 2 (0, 4) | 1 (0, 4) |
| -++-+ | n_unique | 3 (1, 5) | 1 (0, 3) | 0 (0, 2) | 2 (0, 4) | 1 (0, 4) | 1 (0, 3) |
| -++-+ | post_p | NA (NA, NA) | 0.44 (0.31, 0.65) | 0.61 (0.44, 0.8) | 0.45 (0.32, 0.64) | 0.45 (0.3, 0.65) | 0.45 (0.29, 0.63) |
| -++-+ | rate | 0.085 (0, 0.25) | 0.152 (0.045, 0.577) | 0.033 (0, 0.191) | 0.144 (0.045, 0.567) | 0.141 (0.051, 0.496) | 0.142 (0.041, 0.791) |
| -+++- | graduation | 0 | 6 | 401 | 0 | 4 | 3 |
| -+++- | futility | 0 | 256 | 0 | 237 | 245 | 246 |
| -+++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -+++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+++- | post_p | NA (NA, NA) | 0.47 (0.42, 0.51) | NA (NA, NA) | 0.46 (0.46, 0.46) | 0.56 (0.56, 0.56) | 0.49 (0.49, 0.49) |
| -+++- | rate | 0.116 (0, 1.344) | 0.203 (0, 1.352) | 0 (0, 0.235) | 0.119 (0, 3.545) | 0.115 (0.04, 1.431) | 0.122 (0, 0.385) |
| -++++ | graduation | 0 | 6 | 432 | 0 | 4 | 2 |
| -++++ | futility | 0 | 283 | 0 | 266 | 277 | 294 |
| -++++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -++++ | n | 3 (1, 6) | 1 (0, 4) | 0 (0, 3) | 2 (0, 4) | 2 (0, 4) | 1 (0, 4) |
| -++++ | n_unique | 3 (1, 6) | 1 (0, 4) | 0 (0, 2) | 2 (0, 4) | 2 (0, 4) | 1 (0, 3) |
| -++++ | post_p | NA (NA, NA) | 0.44 (0.31, 0.63) | 0.61 (0.44, 0.79) | 0.44 (0.31, 0.67) | 0.43 (0.28, 0.6) | 0.45 (0.31, 0.65) |
| -++++ | rate | 0.077 (0, 0.224) | 0.135 (0.035, 0.487) | 0.039 (0, 0.171) | 0.129 (0.045, 0.46) | 0.138 (0.05, 0.57) | 0.13 (0.038, 0.457) |
| +—- | graduation | 0 | 3 | 225 | 0 | 2 | 1 |
| +—- | futility | 0 | 37 | 0 | 17 | 23 | 26 |
| +—- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +—- | n | 5 (2, 8) | 2 (1, 6) | 3 (0, 6) | 2 (0, 5) | 2 (1, 5) | 2 (1, 5) |
| +—- | n_unique | 4 (2, 8) | 2 (0, 5) | 2 (0, 6) | 2 (0, 4) | 2 (1, 4) | 2 (0, 5) |
| +—- | post_p | NA (NA, NA) | 0.42 (0.26, 0.63) | 0.67 (0.43, 0.89) | 0.41 (0.26, 0.62) | 0.42 (0.26, 0.64) | 0.45 (0.29, 0.65) |
| +—- | rate | 0.082 (0.034, 0.187) | 0.131 (0.047, 0.412) | 0.045 (0, 0.131) | 0.131 (0.041, 0.452) | 0.125 (0.048, 0.442) | 0.112 (0.046, 0.391) |
| +—+ | graduation | 0 | 3 | 336 | 0 | 2 | 1 |
| +—+ | futility | 0 | 146 | 0 | 119 | 130 | 177 |
| +—+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +—+ | n | 2 (0, 4) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| +—+ | n_unique | 2 (0, 4) | 1 (0, 3) | 1 (0, 2) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| +—+ | post_p | NA (NA, NA) | 0.46 (0.33, 0.62) | 0.59 (0.43, 0.78) | 0.46 (0.35, 0.61) | 0.45 (0.34, 0.63) | 0.46 (0.35, 0.6) |
| +—+ | rate | 0.087 (0, 0.292) | 0.139 (0.021, 0.516) | 0.043 (0, 0.165) | 0.129 (0.029, 0.627) | 0.134 (0.029, 0.629) | 0.138 (0.037, 0.522) |
| +–+- | graduation | 0 | 4 | 290 | 0 | 2 | 2 |
| +–+- | futility | 0 | 99 | 0 | 78 | 75 | 101 |
| +–+- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +–+- | n | 8 (4, 12) | 3 (1, 7) | 4 (1, 9) | 3 (1, 8) | 3 (1, 7) | 3 (1, 6) |
| +–+- | n_unique | 7 (4, 12) | 3 (1, 7) | 3 (1, 9) | 3 (1, 7) | 3 (1, 6) | 3 (1, 6) |
| +–+- | post_p | NA (NA, NA) | 0.38 (0.2, 0.68) | 0.76 (0.46, 0.96) | 0.39 (0.25, 0.64) | 0.38 (0.21, 0.64) | 0.39 (0.21, 0.65) |
| +–+- | rate | 0.082 (0.044, 0.149) | 0.144 (0.053, 0.385) | 0.041 (0.013, 0.108) | 0.128 (0.063, 0.488) | 0.138 (0.062, 0.446) | 0.129 (0.055, 0.413) |
| +–++ | graduation | 0 | 4 | 368 | 0 | 2 | 2 |
| +–++ | futility | 0 | 172 | 0 | 150 | 153 | 210 |
| +–++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +–++ | n | 4 (1, 7) | 2 (0, 5) | 1 (0, 4) | 2 (0, 4) | 2 (0, 4) | 2 (0, 5) |
| +–++ | n_unique | 3 (1, 6) | 2 (0, 4) | 1 (0, 4) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) |
| +–++ | post_p | NA (NA, NA) | 0.45 (0.28, 0.64) | 0.65 (0.44, 0.85) | 0.45 (0.28, 0.66) | 0.42 (0.28, 0.66) | 0.42 (0.28, 0.6) |
| +–++ | rate | 0.081 (0.027, 0.235) | 0.127 (0.048, 0.425) | 0.04 (0, 0.137) | 0.126 (0.038, 0.403) | 0.131 (0.043, 0.511) | 0.144 (0.053, 0.565) |
| +-+– | graduation | 0 | 3 | 363 | 0 | 2 | 1 |
| +-+– | futility | 0 | 202 | 0 | 161 | 170 | 183 |
| +-+– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-+– | n | 1 (0, 3) | 1 (0, 2) | 0 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| +-+– | n_unique | 1 (0, 3) | 1 (0, 2) | 0 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| +-+– | post_p | NA (NA, NA) | 0.47 (0.36, 0.62) | 0.55 (0.42, 0.69) | 0.47 (0.39, 0.6) | 0.46 (0.37, 0.61) | 0.46 (0.36, 0.6) |
| +-+– | rate | 0.086 (0, 0.354) | 0.143 (0, 0.72) | 0.043 (0, 0.279) | 0.134 (0, 0.505) | 0.141 (0, 0.67) | 0.135 (0, 0.8) |
| +-+-+ | graduation | 0 | 3 | 408 | 0 | 2 | 1 |
| +-+-+ | futility | 0 | 247 | 0 | 206 | 219 | 255 |
| +-+-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-+-+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +-+-+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +-+-+ | post_p | NA (NA, NA) | 0.47 (0.43, 0.5) | 0.55 (0.55, 0.56) | 0.52 (0.51, 0.52) | 0.48 (0.43, 0.54) | 0.56 (0.56, 0.56) |
| +-+-+ | rate | 0.104 (0, 1.417) | 0.093 (0, 0.546) | 0.039 (0, 0.119) | 0.105 (0, 0.662) | 0.109 (0, 0.782) | 0.128 (0.03, 0.759) |
| +-++- | graduation | 0 | 4 | 389 | 0 | 2 | 2 |
| +-++- | futility | 0 | 229 | 0 | 186 | 194 | 220 |
| +-++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-++- | n | 24 (17, 31) | 6 (2, 18) | 8 (3, 22) | 7 (3, 18) | 7 (3, 18) | 6 (2, 18) |
| +-++- | n_unique | 22 (15, 29) | 6 (2, 16) | 8 (2, 20) | 7 (3, 17) | 6 (2, 17) | 6 (2, 17) |
| +-++- | post_p | NA (NA, NA) | 0.27 (0.1, 0.55) | 0.92 (0.6, 1) | 0.28 (0.1, 0.59) | 0.29 (0.1, 0.58) | 0.28 (0.12, 0.56) |
| +-++- | rate | 0.079 (0.054, 0.108) | 0.133 (0.078, 0.33) | 0.039 (0.02, 0.071) | 0.128 (0.076, 0.275) | 0.122 (0.076, 0.311) | 0.134 (0.081, 0.316) |
| +-+++ | graduation | 0 | 4 | 421 | 0 | 2 | 2 |
| +-+++ | futility | 0 | 263 | 0 | 223 | 233 | 276 |
| +-+++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-+++ | n | 18 (12, 24) | 6 (2, 15) | 4 (1, 13) | 6 (2, 15) | 6 (2, 15) | 5 (2, 16) |
| +-+++ | n_unique | 16 (11, 22) | 5 (1, 14) | 4 (1, 12) | 5 (2, 14) | 5 (2, 14) | 5 (2, 15) |
| +-+++ | post_p | NA (NA, NA) | 0.33 (0.15, 0.61) | 0.84 (0.48, 0.98) | 0.29 (0.13, 0.61) | 0.3 (0.13, 0.67) | 0.3 (0.13, 0.64) |
| +-+++ | rate | 0.078 (0.05, 0.113) | 0.127 (0.074, 0.302) | 0.039 (0.015, 0.095) | 0.131 (0.079, 0.321) | 0.128 (0.077, 0.323) | 0.127 (0.078, 0.281) |
| ++— | graduation | 0 | 5 | 257 | 0 | 4 | 2 |
| ++— | futility | 0 | 88 | 0 | 108 | 121 | 86 |
| ++— | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++— | n | 8 (4, 13) | 3 (1, 7) | 3 (0, 8) | 4 (2, 8) | 4 (2, 8) | 4 (1, 8) |
| ++— | n_unique | 7 (4, 12) | 3 (1, 6) | 3 (0, 8) | 4 (2, 8) | 4 (2, 7) | 3 (1, 7) |
| ++— | post_p | NA (NA, NA) | 0.4 (0.21, 0.69) | 0.75 (0.44, 0.94) | 0.37 (0.2, 0.67) | 0.37 (0.18, 0.65) | 0.38 (0.21, 0.65) |
| ++— | rate | 0.077 (0.04, 0.147) | 0.13 (0.06, 0.383) | 0.04 (0, 0.125) | 0.122 (0.061, 0.297) | 0.125 (0.065, 0.372) | 0.13 (0.065, 0.373) |
| ++–+ | graduation | 0 | 5 | 358 | 0 | 4 | 1 |
| ++–+ | futility | 0 | 175 | 0 | 186 | 200 | 210 |
| ++–+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++–+ | post_p | NA (NA, NA) | 0.52 (0.52, 0.52) | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.5 (0.46, 0.53) | NA (NA, NA) |
| ++–+ | rate | 0.121 (0, 1.239) | 0.089 (0, 0.84) | 0.056 (0, 0.24) | 0.109 (0.013, 0.293) | 0.238 (0, 0.826) | 0.118 (0, 0.37) |
| ++-+- | graduation | 0 | 6 | 313 | 0 | 4 | 3 |
| ++-+- | futility | 0 | 139 | 0 | 155 | 155 | 148 |
| ++-+- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++-+- | n | 1 (0, 3) | 0 (0, 2) | 0 (0, 1) | 1 (0, 2) | 1 (0, 2) | 0 (0, 2) |
| ++-+- | n_unique | 1 (0, 2) | 0 (0, 2) | 0 (0, 1) | 0 (0, 2) | 1 (0, 2) | 0 (0, 2) |
| ++-+- | post_p | NA (NA, NA) | 0.47 (0.4, 0.57) | 0.56 (0.46, 0.63) | 0.47 (0.4, 0.59) | 0.46 (0.38, 0.59) | 0.47 (0.4, 0.57) |
| ++-+- | rate | 0.079 (0, 0.585) | 0.154 (0, 0.651) | 0.025 (0, 0.158) | 0.127 (0, 0.739) | 0.139 (0.031, 0.784) | 0.129 (0, 0.838) |
| ++-++ | graduation | 0 | 6 | 385 | 0 | 4 | 2 |
| ++-++ | futility | 0 | 201 | 0 | 208 | 216 | 241 |
| ++-++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++-++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++-++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++-++ | post_p | NA (NA, NA) | NA (NA, NA) | 0.49 (0.49, 0.49) | 0.49 (0.43, 0.55) | 0.5 (0.46, 0.55) | 0.47 (0.47, 0.47) |
| ++-++ | rate | 0.146 (0, 1.672) | 0.099 (0, 0.204) | 0.057 (0, 0.407) | 0.187 (0, 2.527) | 0.379 (0.052, 1.228) | 0.035 (0, 0.188) |
| +++– | graduation | 0 | 5 | 377 | 0 | 4 | 2 |
| +++– | futility | 0 | 234 | 0 | 219 | 228 | 215 |
| +++– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +++– | n | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) |
| +++– | n_unique | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) |
| +++– | post_p | NA (NA, NA) | 0.52 (0.44, 0.57) | 0.52 (0.43, 0.6) | 0.46 (0.43, 0.55) | 0.48 (0.42, 0.56) | 0.49 (0.44, 0.57) |
| +++– | rate | 0.064 (0, 0.664) | 0.149 (0, 0.578) | 0.048 (0, 0.399) | 0.186 (0, 0.973) | 0.186 (0, 0.715) | 0.109 (0, 0.359) |
| +++-+ | graduation | 0 | 5 | 420 | 0 | 4 | 1 |
| +++-+ | futility | 0 | 267 | 0 | 255 | 266 | 273 |
| +++-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +++-+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++-+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++-+ | post_p | NA (NA, NA) | 0.52 (0.52, 0.52) | 0.47 (0.47, 0.47) | 0.44 (0.41, 0.47) | 0.55 (0.47, 0.57) | 0.48 (0.47, 0.5) |
| +++-+ | rate | 0.075 (0, 0.529) | 0.09 (0, 0.606) | 0.085 (0.012, 0.308) | 0.182 (0.041, 0.943) | 0.121 (0.029, 1.358) | 0.085 (0, 1.108) |
| ++++- | graduation | 0 | 6 | 401 | 0 | 4 | 3 |
| ++++- | futility | 0 | 256 | 0 | 237 | 245 | 246 |
| ++++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++- | post_p | NA (NA, NA) | 0.48 (0.46, 0.49) | 0.54 (0.54, 0.54) | 0.47 (0.47, 0.47) | 0.54 (0.54, 0.54) | NA (NA, NA) |
| ++++- | rate | 0.063 (0, 0.498) | 0.117 (0, 2.046) | 0.019 (0, 0.599) | 0.128 (0, 0.803) | 0.061 (0, 0.491) | 0.121 (0, 0.832) |
| +++++ | graduation | 0 | 6 | 432 | 0 | 4 | 2 |
| +++++ | futility | 0 | 283 | 0 | 266 | 277 | 294 |
| +++++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++++ | post_p | NA (NA, NA) | 0.48 (0.43, 0.5) | 0.52 (0.45, 0.59) | 0.52 (0.47, 0.57) | 0.47 (0.42, 0.48) | 0.55 (0.46, 0.57) |
| +++++ | rate | 0.08 (0, 0.373) | 0.176 (0, 0.55) | 0.061 (0, 0.888) | 0.169 (0, 1.082) | 0.185 (0, 0.836) | 0.057 (0, 0.796) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| all | count | 3 | 225 | 2 | 1 | |
| all | time_stop | 5 (5, 5) | 10 (5, 28) | 7 (6, 8) | 5 (5, 5) | |
| all | n_trt | 30 (28, 33) | 55 (28, 144) | 27 (25, 29) | 33 (33, 33) | |
| all | n_control | 52 (43, 54) | 88 (49, 295) | 62 (57, 68) | 46 (46, 46) | |
| all | post_p | 0.91 (0.88, 0.94) | 1 (0.92, 1) | 0.9 (0.9, 0.91) | 0.86 (0.86, 0.86) | |
| all | order | 1 (1, 1) | 1 (1, 4) | 1.5 (1.1, 1.9) | 1 (1, 1) | |
| AR- & TP53- | count | 4 | 325 | 2 | 4 | 2 |
| AR- & TP53- | time_stop | 6 (5, 7) | 11 (8, 25) | 10 (10, 11) | 14 (10, 15) | 14 (12, 16) |
| AR- & TP53- | n_trt | 30 (26, 33) | 35 (25, 115) | 28 (26, 30) | 36 (26, 52) | 29 (27, 31) |
| AR- & TP53- | n_control | 42 (29, 54) | 60 (38, 150) | 58 (56, 60) | 72 (52, 87) | 82 (69, 94) |
| AR- & TP53- | post_p | 0.92 (0.89, 0.96) | 0.98 (0.91, 1) | 0.96 (0.94, 0.99) | 0.96 (0.93, 0.99) | 0.93 (0.92, 0.95) |
| AR- & TP53- | order | 1 (1, 1) | 1 (1, 3) | 2 (1.2, 2.8) | 1.5 (1, 2) | 2 (2, 2) |
| HRD+ | count | 2 | 40 | 2 | 1 | |
| HRD+ | time_stop | 20 (20, 21) | 28 (21, 35) | 20 (15, 26) | 20 (20, 20) | |
| HRD+ | n_trt | 28 (26, 29) | 26 (25, 37) | 25 (25, 25) | 26 (26, 26) | |
| HRD+ | n_control | 33 (33, 33) | 45 (29, 62) | 30 (17, 43) | 25 (25, 25) | |
| HRD+ | post_p | 0.89 (0.87, 0.92) | 0.99 (0.95, 1) | 0.9 (0.86, 0.94) | 0.93 (0.93, 0.93) | |
| HRD+ | order | 4 (3.2, 4.8) | 2 (1, 5) | 4 (2.4, 5.6) | 2 (2, 2) | |
| TP53+ | count | 219 | ||||
| TP53+ | time_stop | 18 (12, 29) | ||||
| TP53+ | n_trt | 37 (26, 70) | ||||
| TP53+ | n_control | 52 (33, 98) | ||||
| TP53+ | post_p | 1 (0.96, 1) | ||||
| TP53+ | order | 2 (1, 4) | ||||
| TEfus+ | count | 1 | 146 | 1 | ||
| TEfus+ | time_stop | 21 (21, 21) | 19 (12, 31) | 12 (12, 12) | ||
| TEfus+ | n_trt | 28 (28, 28) | 34 (25, 58) | 26 (26, 26) | ||
| TEfus+ | n_control | 59 (59, 59) | 53 (31, 108) | 31 (31, 31) | ||
| TEfus+ | post_p | 0.98 (0.98, 0.98) | 1 (0.98, 1) | 0.87 (0.87, 0.87) | ||
| TEfus+ | order | 1 (1, 1) | 3 (1, 5) | 1 (1, 1) | ||
| PI3K+ | count | 173 | ||||
| PI3K+ | time_stop | 20 (14, 31) | ||||
| PI3K+ | n_trt | 31 (25, 57) | ||||
| PI3K+ | n_control | 59 (36, 107) | ||||
| PI3K+ | post_p | 1 (0.97, 1) | ||||
| PI3K+ | order | 2 (1, 4) |
| signature | var | TC1 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|
| all | count | 37 | 17 | 23 | 26 |
| all | time_stop | 16 (3, 31) | 28 (11, 35) | 26 (9, 35) | 24 (10, 34) |
| all | n_trt | 72 (27, 112) | 85 (47, 119) | 78 (33, 129) | 70 (39, 124) |
| all | n_control | 152 (34, 331) | 290 (78, 412) | 269 (87, 405) | 250 (82, 387) |
| all | post_p | 0 (0, 0.18) | 0 (0, 0.06) | 0 (0, 0.01) | 0 (0, 0.02) |
| all | order | 3 (1, 7) | 5 (1, 9) | 4 (1, 8) | 6 (1, 8.5) |
| AR- & TP53- | count | 250 | 232 | 213 | 245 |
| AR- & TP53- | time_stop | 18 (7, 32) | 22 (12, 33) | 21 (12, 33) | 23 (13, 32) |
| AR- & TP53- | n_trt | 45 (26, 93) | 50 (27, 102) | 43 (26, 111) | 43 (26, 112) |
| AR- & TP53- | n_control | 104 (37, 213) | 134 (65, 219) | 125 (64, 219) | 140 (68, 219) |
| AR- & TP53- | post_p | 0.03 (0, 0.19) | 0.01 (0, 0.12) | 0.03 (0, 0.11) | 0.02 (0, 0.13) |
| AR- & TP53- | order | 2 (1, 6) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) |
| HRD+ | count | 53 | 96 | 102 | 62 |
| HRD+ | time_stop | 32 (24, 35) | 27 (20, 35) | 30 (22, 34) | 31 (25, 36) |
| HRD+ | n_trt | 28 (25, 40) | 28 (25, 38) | 29 (25, 40) | 28 (25, 40) |
| HRD+ | n_control | 54 (36, 66) | 41 (26, 62) | 47 (31, 64) | 50 (35, 65) |
| HRD+ | post_p | 0.05 (0.01, 0.22) | 0.07 (0.01, 0.19) | 0.06 (0.01, 0.2) | 0.07 (0.01, 0.19) |
| HRD+ | order | 6 (3, 8) | 4 (1, 8) | 5 (2, 8.9) | 6 (3, 9) |
| TP53+ | count | 182 | 156 | 165 | 177 |
| TP53+ | time_stop | 24 (15, 34) | 24 (16, 32) | 25 (16, 34) | 23 (13, 34) |
| TP53+ | n_trt | 38 (25, 62) | 34 (26, 53) | 37 (26, 63) | 33 (25, 59) |
| TP53+ | n_control | 78 (44, 124) | 78 (47, 117) | 84 (46, 124) | 76 (34, 129) |
| TP53+ | post_p | 0.03 (0, 0.11) | 0.03 (0, 0.12) | 0.03 (0, 0.1) | 0.03 (0, 0.12) |
| TP53+ | order | 3 (1, 7) | 3 (1, 6.5) | 3 (1, 7.6) | 3 (1, 7) |
| TEfus+ | count | 78 | 72 | 69 | 92 |
| TEfus+ | time_stop | 27 (17, 35) | 26 (17, 34) | 26 (16, 35) | 24 (17, 35) |
| TEfus+ | n_trt | 36 (26, 49) | 33 (25, 50) | 34 (26, 53) | 34 (25, 53) |
| TEfus+ | n_control | 87 (46, 122) | 84 (49, 121) | 80 (44, 125) | 75 (43, 124) |
| TEfus+ | post_p | 0.01 (0, 0.06) | 0.01 (0, 0.1) | 0.02 (0, 0.07) | 0.01 (0, 0.11) |
| TEfus+ | order | 5 (2, 8) | 5 (2, 8) | 5 (2, 8) | 5 (2, 8.9) |
| PI3K+ | count | 125 | 113 | 122 | 172 |
| PI3K+ | time_stop | 25 (16, 35) | 26 (17, 34) | 25 (17, 35) | 19 (10, 33) |
| PI3K+ | n_trt | 36 (26, 66) | 36 (26, 53) | 36 (26, 61) | 34 (26, 58) |
| PI3K+ | n_control | 79 (48, 121) | 86 (48, 127) | 80 (51, 125) | 57 (23, 118) |
| PI3K+ | post_p | 0.02 (0, 0.09) | 0.02 (0, 0.09) | 0.02 (0, 0.07) | 0.03 (0, 0.18) |
| PI3K+ | order | 5 (2, 8) | 4 (2, 8) | 5 (2, 8) | 3 (1, 6.9) |
| signature | treatment | var | —– | —-+ | —+- | —++ | –+– | –+-+ | –++- | –+++ | -+— | -+–+ | -+-+- | -+-++ | -++– | -++-+ | -+++- | -++++ | +—- | +—+ | +–+- | +–++ | +-+– | +-+-+ | +-++- | +-+++ | ++— | ++–+ | ++-+- | ++-++ | +++– | +++-+ | ++++- | +++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| all | TC1 | time | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) |
| all | TC1 | n | 17 (13, 19) | 2 (0, 3) | 0 (0, 2) | 2 (0, 2) | 3 (1, 4) | 2 (0, 3) | 0 (0, 0) | 1 (1, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 1 (0, 1) | 0 (0, 0) | 0 (0, 2) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 2 (0, 3) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.7 (0.69, 0.75) | 0.55 (0.55, 0.55) | NA (NA, NA) | 0.54 (0.52, 0.57) | 0.54 (0.54, 0.55) | 0.54 (0.53, 0.55) | NA (NA, NA) | 0.52 (0.51, 0.53) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.5 (0.5, 0.5) | NA (NA, NA) | NA (NA, NA) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | 0.57 (0.57, 0.57) | NA (NA, NA) | 0.51 (0.51, 0.51) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.58 (0.58, 0.58) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.034 (0.032, 0.039) | 0.073 (0.015, 0.131) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 |
| all | TC2 | time | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) | 10 (5, 28) |
| all | TC2 | n | 18 (9, 56) | 3 (0, 9) | 1 (0, 2) | 1 (0, 4) | 4 (1, 12) | 3 (1, 11) | 2 (0, 5) | 3 (0, 9) | 2 (0, 10) | 0 (0, 0) | 1 (0, 4) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 2) | 1 (0, 4) | 0 (0, 2) | 2 (0, 5) | 1 (0, 3) | 0 (0, 1) | 0 (0, 0) | 5 (2, 14) | 3 (1, 8) | 1 (0, 5) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.9 (0.61, 1) | 0.62 (0.52, 0.92) | 0.55 (0.52, 0.68) | 0.57 (0.52, 0.83) | 0.64 (0.52, 0.94) | 0.59 (0.52, 0.91) | 0.57 (0.52, 0.78) | 0.61 (0.52, 0.93) | 0.62 (0.53, 0.91) | NA (NA, NA) | 0.61 (0.52, 0.82) | 0.57 (0.52, 0.73) | 0.52 (0.52, 0.52) | 0.58 (0.51, 0.68) | NA (NA, NA) | 0.58 (0.51, 0.75) | 0.55 (0.51, 0.73) | 0.55 (0.51, 0.6) | 0.57 (0.51, 0.8) | 0.58 (0.52, 0.75) | 0.54 (0.51, 0.6) | 0.53 (0.53, 0.53) | 0.61 (0.52, 0.96) | 0.61 (0.51, 0.88) | 0.6 (0.52, 0.85) | NA (NA, NA) | 0.54 (0.52, 0.64) | 0.5 (0.5, 0.5) | 0.54 (0.52, 0.57) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.033 (0, 0.06) | 0 (0, 0.066) | 0 (0, 0.109) | 0 (0, 0.071) | 0 (0, 0.08) | 0.016 (0, 0.076) | 0 (0, 0.084) | 0 (0, 0.077) | 0 (0, 0.068) | 0 (0, 0) | 0 (0, 0.08) | 0 (0, 0.08) | 0 (0, 0.056) | 0 (0, 0.063) | 0.053 (0.011, 0.095) | 0 (0, 0.073) | 0 (0, 0.093) | 0 (0, 0.098) | 0 (0, 0.075) | 0 (0, 0.138) | 0 (0, 0.258) | 0 (0, 0.034) | 0.018 (0, 0.065) | 0 (0, 0.077) | 0 (0, 0.068) | 0 (0, 0) | 0 (0, 0.118) | 0 (0, 0.08) | 0 (0, 0.541) | 0.203 (0.041, 0.366) | 0 (0, 0) | 0.342 (0.08, 1.138) |
| all | TC4 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| all | TC4 | time | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) | 7 (6, 8) |
| all | TC4 | n | 3 (1, 5) | 2 (1, 3) | 0 (0, 0) | 2 (1, 3) | 2 (1, 3) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 7 (7, 7) | 0 (0, 0) | 4 (3, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 2 (1, 3) | 1 (0, 2) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC4 | post_p | 0.63 (0.63, 0.63) | 0.58 (0.54, 0.61) | NA (NA, NA) | 0.56 (0.53, 0.59) | 0.61 (0.59, 0.62) | 0.57 (0.57, 0.57) | 0.61 (0.61, 0.61) | 0.51 (0.51, 0.51) | 0.57 (0.52, 0.61) | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.54 (0.54, 0.54) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.53 (0.51, 0.54) | 0.51 (0.51, 0.51) | 0.51 (0.51, 0.51) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) |
| all | TC4 | rate | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.09 (0.059, 0.121) | NA (NA, NA) | 0.028 (0.006, 0.05) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0.03 (0.006, 0.054) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| all | TC5 | time | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) |
| all | TC5 | n | 1 (1, 1) | 9 (9, 9) | 1 (1, 1) | 1 (1, 1) | 0 (0, 0) | 7 (7, 7) | 0 (0, 0) | 3 (3, 3) | 1 (1, 1) | 0 (0, 0) | 1 (1, 1) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 4 (4, 4) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | post_p | 0.55 (0.55, 0.55) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.62 (0.62, 0.62) | NA (NA, NA) | NA (NA, NA) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.53 (0.53, 0.53) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | rate | 0 (0, 0) | 0 (0, 0) | 5.392 (5.392, 5.392) | 0 (0, 0) | NA (NA, NA) | 0.039 (0.039, 0.039) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| AR- & TP53- | TC1 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | time | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | n | 22 (19, 27) | 3 (1, 4) | 2 (2, 2) | 1 (0, 2) | 2 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | post_p | 0.81 (0.79, 0.89) | 0.69 (0.59, 0.71) | 0.52 (0.52, 0.52) | 0.53 (0.51, 0.55) | 0.57 (0.53, 0.59) | NA (NA, NA) | 0.54 (0.54, 0.54) | NA (NA, NA) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | rate | 0.044 (0.039, 0.051) | 0 (0, 0.065) | 0 (0, 0.158) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | count | 325 | 325 | 325 | 325 | 325 | 325 | 325 | 325 | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | time | 11 (8, 25) | 11 (8, 25) | 11 (8, 25) | 11 (8, 25) | 11 (8, 25) | 11 (8, 25) | 11 (8, 25) | 11 (8, 25) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | n | 24 (17, 80) | 4 (1, 12) | 1 (0, 3) | 2 (0, 5) | 3 (1, 11) | 0 (0, 0) | 2 (0, 5) | 0 (0, 2) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | post_p | 0.94 (0.77, 1) | 0.64 (0.52, 0.9) | 0.55 (0.51, 0.7) | 0.58 (0.52, 0.8) | 0.63 (0.52, 0.91) | 0.61 (0.61, 0.61) | 0.57 (0.52, 0.78) | 0.55 (0.51, 0.71) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | rate | 0.035 (0.014, 0.054) | 0 (0, 0.073) | 0 (0, 0.118) | 0 (0, 0.084) | 0 (0, 0.083) | 0 (0, 0) | 0 (0, 0.081) | 0 (0, 0.096) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | time | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | n | 16 (15, 17) | 4 (2, 6) | 0 (0, 1) | 2 (1, 2) | 2 (1, 2) | 0 (0, 0) | 3 (1, 5) | 2 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | post_p | 0.88 (0.86, 0.89) | 0.73 (0.58, 0.88) | 0.53 (0.53, 0.53) | 0.6 (0.53, 0.67) | 0.6 (0.54, 0.67) | NA (NA, NA) | 0.51 (0.51, 0.51) | NA (NA, NA) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | rate | 0.021 (0.021, 0.021) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.052 (0.01, 0.093) | 0.07 (0.07, 0.07) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | time | 14 (10, 15) | 14 (10, 15) | 14 (10, 15) | 14 (10, 15) | 14 (10, 15) | 14 (10, 15) | 14 (10, 15) | 14 (10, 15) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | n | 16 (14, 28) | 4 (2, 5) | 0 (0, 0) | 3 (1, 6) | 6 (5, 12) | 0 (0, 0) | 4 (1, 6) | 0 (0, 2) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | post_p | 0.84 (0.78, 0.92) | 0.56 (0.5, 0.7) | NA (NA, NA) | 0.62 (0.55, 0.7) | 0.64 (0.55, 0.8) | NA (NA, NA) | 0.58 (0.53, 0.67) | 0.5 (0.5, 0.5) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | rate | 0.042 (0.033, 0.051) | 0.032 (0, 0.094) | NA (NA, NA) | 0.041 (0.008, 0.062) | 0.064 (0.015, 0.08) | NA (NA, NA) | 0.05 (0.038, 0.075) | 0.09 (0.09, 0.09) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | time | 14 (12, 16) | 14 (12, 16) | 14 (12, 16) | 14 (12, 16) | 14 (12, 16) | 14 (12, 16) | 14 (12, 16) | 14 (12, 16) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | n | 13 (11, 15) | 6 (4, 8) | 0 (0, 1) | 2 (1, 4) | 6 (5, 6) | 0 (0, 0) | 2 (1, 2) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | post_p | 0.74 (0.73, 0.74) | 0.63 (0.53, 0.73) | NA (NA, NA) | 0.61 (0.6, 0.62) | 0.73 (0.72, 0.73) | NA (NA, NA) | 0.55 (0.52, 0.57) | NA (NA, NA) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | rate | 0.049 (0.039, 0.058) | 0.096 (0.091, 0.101) | 0 (0, 0) | 0.016 (0.003, 0.029) | 0.011 (0.002, 0.02) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | ||||||||||||||||||||||||
| HRD+ | TC1 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| HRD+ | TC1 | time | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | ||||||||||||||||
| HRD+ | TC1 | n | 14 (12, 16) | 0 (0, 0) | 4 (4, 5) | 2 (0, 3) | 0 (0, 0) | 2 (1, 2) | 0 (0, 0) | 1 (0, 2) | 4 (3, 5) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | post_p | 0.73 (0.72, 0.74) | NA (NA, NA) | 0.71 (0.6, 0.82) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.52 (0.52, 0.52) | NA (NA, NA) | 0.59 (0.59, 0.59) | 0.62 (0.58, 0.66) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | rate | 0.056 (0.053, 0.06) | NA (NA, NA) | 0.03 (0.006, 0.054) | 0.117 (0.117, 0.117) | NA (NA, NA) | 1.114 (0.273, 1.956) | NA (NA, NA) | 0.048 (0.048, 0.048) | 0.075 (0.071, 0.079) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0.274 (0.274, 0.274) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC2 | count | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | ||||||||||||||||
| HRD+ | TC2 | time | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | 28 (21, 35) | ||||||||||||||||
| HRD+ | TC2 | n | 14 (8, 20) | 0 (0, 0) | 5 (1, 9) | 2 (0, 4) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 3) | 5 (3, 9) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC2 | post_p | 0.93 (0.77, 0.99) | NA (NA, NA) | 0.78 (0.57, 0.86) | 0.65 (0.53, 0.86) | NA (NA, NA) | 0.65 (0.52, 0.81) | NA (NA, NA) | 0.59 (0.51, 0.82) | 0.76 (0.58, 0.9) | NA (NA, NA) | 0.56 (0.53, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC2 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC2 | rate | 0.034 (0.02, 0.053) | NA (NA, NA) | 0.038 (0, 0.071) | 0.014 (0, 0.106) | 0.044 (0.044, 0.044) | 0.016 (0, 0.063) | NA (NA, NA) | 0 (0, 0.132) | 0.034 (0, 0.061) | 1.042 (0.367, 1.717) | 0 (0, 0.129) | 0 (0, 0) | 1.004 (0.394, 1.613) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC4 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| HRD+ | TC4 | time | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | 20 (15, 26) | ||||||||||||||||
| HRD+ | TC4 | n | 11 (11, 11) | 0 (0, 0) | 5 (5, 5) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 2 (1, 2) | 7 (6, 8) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC4 | post_p | 0.77 (0.73, 0.81) | NA (NA, NA) | 0.56 (0.52, 0.6) | 0.59 (0.59, 0.59) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.54 (0.54, 0.55) | 0.77 (0.77, 0.77) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC4 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| HRD+ | TC4 | rate | 0.051 (0.05, 0.051) | NA (NA, NA) | 0.093 (0.067, 0.119) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.031 (0.006, 0.056) | 0.063 (0.061, 0.065) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC5 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| HRD+ | TC5 | time | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | ||||||||||||||||
| HRD+ | TC5 | n | 14 (14, 14) | 0 (0, 0) | 2 (2, 2) | 5 (5, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 3 (3, 3) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | ||||||||||||||||
| HRD+ | TC5 | post_p | 0.96 (0.96, 0.96) | NA (NA, NA) | 0.52 (0.52, 0.52) | 0.66 (0.66, 0.66) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.68 (0.68, 0.68) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC5 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC5 | rate | 0.062 (0.062, 0.062) | NA (NA, NA) | 0.111 (0.111, 0.111) | 0.084 (0.084, 0.084) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.075 (0.075, 0.075) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | count | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | ||||||||||||||||
| TP53+ | TC2 | time | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | ||||||||||||||||
| TP53+ | TC2 | n | 8 (4, 18) | 6 (3, 14) | 3 (1, 6) | 5 (2, 12) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 1 (0, 2) | 0 (0, 2) | 0 (0, 0) | 9 (4, 16) | 5 (2, 10) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | post_p | 0.79 (0.56, 0.98) | 0.75 (0.58, 0.95) | 0.6 (0.51, 0.8) | 0.75 (0.54, 0.92) | NA (NA, NA) | 0.57 (0.52, 0.7) | NA (NA, NA) | 0.57 (0.52, 0.74) | 0.54 (0.51, 0.61) | 0.56 (0.54, 0.58) | 0.81 (0.64, 0.96) | 0.73 (0.54, 0.91) | 0.54 (0.53, 0.58) | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.51) | ||||||||||||||||
| TP53+ | TC2 | r_prob | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | rate | 0.034 (0, 0.077) | 0.034 (0, 0.071) | 0.027 (0, 0.08) | 0.034 (0, 0.076) | 0.035 (0, 0.191) | 0 (0, 0.108) | 0.106 (0.021, 0.363) | 0 (0, 0.08) | 0 (0, 0.22) | 0.039 (0, 0.131) | 0.033 (0, 0.063) | 0.03 (0, 0.077) | 0 (0, 0.967) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.829) | ||||||||||||||||
| TEfus+ | TC1 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| TEfus+ | TC1 | time | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | ||||||||||||||||
| TEfus+ | TC1 | n | 0 (0, 0) | 3 (3, 3) | 3 (3, 3) | 4 (4, 4) | 3 (3, 3) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 10 (10, 10) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | post_p | NA (NA, NA) | 0.65 (0.65, 0.65) | 0.57 (0.57, 0.57) | 0.92 (0.92, 0.92) | 0.66 (0.66, 0.66) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.82 (0.82, 0.82) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | rate | NA (NA, NA) | 0.06 (0.06, 0.06) | 0.074 (0.074, 0.074) | 0 (0, 0) | 0.044 (0.044, 0.044) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.044 (0.044, 0.044) | 0.052 (0.052, 0.052) | 0.095 (0.095, 0.095) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC2 | count | 146 | 146 | 146 | 146 | 146 | 146 | 146 | 146 | 146 | 146 | 146 | 146 | 146 | 146 | 146 | 146 | ||||||||||||||||
| TEfus+ | TC2 | time | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | 19 (12, 31) | ||||||||||||||||
| TEfus+ | TC2 | n | 1 (0, 3) | 2 (0, 6) | 3 (0, 6) | 5 (2, 13) | 2 (0, 5) | 0 (0, 2) | 0 (0, 0) | 1 (0, 2) | 4 (1, 8) | 2 (0, 4) | 9 (4, 17) | 5 (2, 9) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | post_p | 0.58 (0.52, 0.8) | 0.67 (0.53, 0.88) | 0.62 (0.52, 0.88) | 0.77 (0.58, 0.95) | 0.64 (0.52, 0.82) | 0.59 (0.54, 0.71) | NA (NA, NA) | 0.58 (0.52, 0.73) | 0.67 (0.52, 0.9) | 0.6 (0.52, 0.73) | 0.83 (0.63, 0.97) | 0.75 (0.54, 0.94) | 0.55 (0.52, 0.6) | 0.5 (0.5, 0.5) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | rate | 0 (0, 0.107) | 0.027 (0, 0.081) | 0.028 (0, 0.079) | 0.029 (0, 0.066) | 0.021 (0, 0.084) | 0 (0, 0.097) | 0.053 (0.011, 0.095) | 0 (0, 0.085) | 0.036 (0, 0.091) | 0.027 (0, 0.088) | 0.031 (0, 0.065) | 0.031 (0, 0.078) | 0 (0, 0.166) | 0.057 (0, 0.317) | 0 (0, 0) | 0.342 (0.123, 1.138) | ||||||||||||||||
| TEfus+ | TC5 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| TEfus+ | TC5 | time | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | ||||||||||||||||
| TEfus+ | TC5 | n | 1 (1, 1) | 5 (5, 5) | 1 (1, 1) | 2 (2, 2) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 2 (2, 2) | 0 (0, 0) | 8 (8, 8) | 4 (4, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | post_p | 0.52 (0.52, 0.52) | 0.58 (0.58, 0.58) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.63 (0.63, 0.63) | NA (NA, NA) | NA (NA, NA) | 0.56 (0.56, 0.56) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.74 (0.74, 0.74) | 0.57 (0.57, 0.57) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | rate | 0 (0, 0) | 0.049 (0.049, 0.049) | 0 (0, 0) | 0.066 (0.066, 0.066) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.114 (0.114, 0.114) | 0.046 (0.046, 0.046) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | count | 173 | 173 | 173 | 173 | 173 | 173 | 173 | 173 | 173 | 173 | 173 | 173 | 173 | 173 | 173 | 173 | ||||||||||||||||
| PI3K+ | TC2 | time | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | 20 (14, 31) | ||||||||||||||||
| PI3K+ | TC2 | n | 6 (2, 15) | 2 (0, 6) | 8 (3, 15) | 6 (2, 13) | 0 (0, 0) | 1 (0, 3) | 0 (0, 2) | 1 (0, 2) | 1 (0, 3) | 2 (0, 4) | 0 (0, 0) | 5 (2, 10) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | post_p | 0.8 (0.57, 0.97) | 0.68 (0.52, 0.86) | 0.79 (0.59, 0.96) | 0.77 (0.54, 0.95) | NA (NA, NA) | 0.59 (0.52, 0.81) | 0.57 (0.52, 0.73) | 0.57 (0.51, 0.76) | 0.56 (0.52, 0.7) | 0.6 (0.52, 0.74) | 0.53 (0.53, 0.53) | 0.75 (0.56, 0.95) | NA (NA, NA) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | r_prob | 0.03 (0.03, 0.03) | 0.03 (0.03, 0.03) | 0.07 (0.07, 0.07) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.21 (0.21, 0.21) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | rate | 0.032 (0, 0.069) | 0.031 (0, 0.079) | 0.034 (0, 0.072) | 0.035 (0, 0.077) | 0 (0, 0) | 0 (0, 0.099) | 0 (0, 0.112) | 0 (0, 0.09) | 0 (0, 0.12) | 0.024 (0, 0.096) | 0.048 (0, 0.101) | 0.029 (0, 0.076) | 0.199 (0, 1.227) | 0.114 (0, 0.406) | 0 (0, 0) | 0.061 (0, 0.829) |
| signature | treatment | var | —– | —-+ | —+- | —++ | –+– | –+-+ | –++- | –+++ | -+— | -+–+ | -+-+- | -+-++ | -++– | -++-+ | -+++- | -++++ | +—- | +—+ | +–+- | +–++ | +-+– | +-+-+ | +-++- | +-+++ | ++— | ++–+ | ++-+- | ++-++ | +++– | +++-+ | ++++- | +++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 37 |
| all | TC1 | time | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) | 16 (3, 31) |
| all | TC1 | n | 19 (13, 30) | 4 (1, 13) | 1 (0, 3) | 2 (0, 4) | 5 (3, 12) | 3 (0, 10) | 1 (0, 4) | 3 (0, 9) | 1 (0, 8) | 0 (0, 0) | 0 (0, 5) | 0 (0, 2) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 2) | 1 (0, 3) | 0 (0, 1) | 1 (0, 3) | 1 (0, 3) | 0 (0, 2) | 0 (0, 0) | 3 (0, 7) | 2 (0, 6) | 0 (0, 3) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.23 (0.03, 0.41) | 0.33 (0.14, 0.48) | 0.43 (0.33, 0.48) | 0.4 (0.21, 0.48) | 0.4 (0.22, 0.48) | 0.29 (0.17, 0.46) | 0.42 (0.29, 0.49) | 0.34 (0.15, 0.47) | 0.32 (0.2, 0.45) | NA (NA, NA) | 0.38 (0.25, 0.49) | 0.39 (0.25, 0.47) | NA (NA, NA) | 0.46 (0.33, 0.48) | NA (NA, NA) | 0.43 (0.34, 0.45) | 0.4 (0.25, 0.47) | 0.44 (0.38, 0.49) | 0.39 (0.28, 0.46) | 0.39 (0.31, 0.44) | 0.46 (0.4, 0.47) | NA (NA, NA) | 0.34 (0.15, 0.45) | 0.35 (0.21, 0.48) | 0.39 (0.22, 0.48) | NA (NA, NA) | 0.44 (0.44, 0.44) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.124 (0.085, 0.167) | 0.162 (0.065, 0.675) | 0.205 (0.015, 0.708) | 0.272 (0.054, 1.267) | 0.113 (0.026, 0.3) | 0.161 (0.049, 0.439) | 0.153 (0, 0.589) | 0.165 (0.09, 0.546) | 0.135 (0.103, 0.389) | NA (NA, NA) | 0.136 (0.074, 0.307) | 0.22 (0.119, 1.606) | NA (NA, NA) | 0.24 (0.082, 2.269) | 0.107 (0.107, 0.107) | 0.119 (0, 1.307) | 0.219 (0.05, 0.361) | 0.178 (0, 0.321) | 0.255 (0.11, 1.793) | 0.181 (0, 0.769) | 0.181 (0, 0.385) | NA (NA, NA) | 0.14 (0, 0.363) | 0.128 (0, 0.502) | 0.151 (0.037, 0.335) | 0.041 (0.008, 0.074) | 0.4 (0.215, 1.503) | 0.091 (0.091, 0.091) | 0.198 (0.198, 0.198) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | count | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 |
| all | TC3 | time | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) | 28 (11, 35) |
| all | TC3 | n | 14 (8, 43) | 6 (3, 15) | 0 (0, 3) | 2 (1, 4) | 5 (3, 7) | 4 (2, 11) | 2 (0, 5) | 3 (1, 7) | 4 (2, 12) | 0 (0, 0) | 4 (2, 6) | 1 (0, 2) | 0 (0, 0) | 2 (0, 2) | 0 (0, 0) | 0 (0, 3) | 2 (0, 4) | 0 (0, 1) | 3 (0, 5) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 3 (1, 8) | 5 (1, 8) | 4 (1, 6) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC3 | post_p | 0.15 (0.03, 0.41) | 0.32 (0.1, 0.47) | 0.4 (0.36, 0.48) | 0.35 (0.2, 0.46) | 0.31 (0.13, 0.44) | 0.28 (0.18, 0.47) | 0.35 (0.21, 0.44) | 0.34 (0.19, 0.49) | 0.29 (0.15, 0.44) | NA (NA, NA) | 0.34 (0.18, 0.44) | 0.4 (0.28, 0.49) | NA (NA, NA) | 0.42 (0.32, 0.49) | NA (NA, NA) | 0.45 (0.36, 0.49) | 0.34 (0.32, 0.44) | 0.42 (0.32, 0.46) | 0.4 (0.25, 0.47) | 0.41 (0.32, 0.47) | 0.47 (0.46, 0.47) | NA (NA, NA) | 0.34 (0.24, 0.42) | 0.33 (0.17, 0.49) | 0.39 (0.25, 0.45) | NA (NA, NA) | 0.45 (0.42, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) |
| all | TC3 | rate | 0.118 (0.087, 0.156) | 0.121 (0.09, 0.195) | 0.135 (0.062, 0.222) | 0.199 (0.072, 0.444) | 0.158 (0.091, 0.312) | 0.15 (0.107, 0.268) | 0.215 (0.122, 0.465) | 0.129 (0.065, 0.296) | 0.141 (0.114, 0.423) | 0.202 (0.202, 0.202) | 0.141 (0.084, 0.265) | 0.17 (0.057, 0.483) | 0.137 (0.113, 0.161) | 0.181 (0.069, 0.71) | 0 (0, 0) | 0.267 (0.074, 0.905) | 0.158 (0.111, 0.297) | 0.322 (0.164, 0.836) | 0.107 (0.069, 0.242) | 0.19 (0.138, 1.978) | 0.167 (0.033, 0.221) | NA (NA, NA) | 0.166 (0.097, 0.762) | 0.149 (0.075, 0.634) | 0.139 (0.07, 0.431) | NA (NA, NA) | 0.201 (0.089, 0.692) | NA (NA, NA) | NA (NA, NA) | 0.236 (0.145, 0.327) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | count | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 |
| all | TC4 | time | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) | 26 (9, 35) |
| all | TC4 | n | 15 (4, 50) | 6 (1, 12) | 0 (0, 4) | 3 (0, 7) | 5 (3, 12) | 5 (3, 11) | 2 (0, 4) | 3 (1, 6) | 7 (3, 14) | 0 (0, 0) | 4 (2, 6) | 2 (0, 3) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 0 (0, 3) | 1 (0, 5) | 0 (0, 2) | 2 (0, 6) | 1 (0, 2) | 0 (0, 1) | 0 (0, 0) | 4 (2, 12) | 4 (2, 6) | 3 (1, 6) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC4 | post_p | 0.18 (0.03, 0.35) | 0.33 (0.12, 0.41) | 0.43 (0.36, 0.47) | 0.38 (0.25, 0.47) | 0.31 (0.12, 0.48) | 0.24 (0.14, 0.44) | 0.38 (0.25, 0.45) | 0.33 (0.2, 0.48) | 0.3 (0.1, 0.42) | NA (NA, NA) | 0.38 (0.23, 0.49) | 0.38 (0.3, 0.49) | NA (NA, NA) | 0.39 (0.27, 0.49) | NA (NA, NA) | 0.44 (0.36, 0.47) | 0.42 (0.24, 0.48) | 0.47 (0.43, 0.48) | 0.38 (0.25, 0.46) | 0.42 (0.34, 0.49) | 0.43 (0.34, 0.47) | NA (NA, NA) | 0.38 (0.17, 0.47) | 0.34 (0.18, 0.47) | 0.42 (0.28, 0.46) | NA (NA, NA) | 0.48 (0.44, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) |
| all | TC4 | rate | 0.139 (0.086, 0.353) | 0.12 (0.097, 0.539) | 0.16 (0.101, 0.354) | 0.14 (0.098, 0.322) | 0.132 (0.096, 0.259) | 0.172 (0.096, 0.329) | 0.156 (0.095, 0.348) | 0.152 (0.089, 0.562) | 0.16 (0.084, 0.323) | NA (NA, NA) | 0.163 (0.091, 0.31) | 0.2 (0.055, 0.306) | 0.213 (0.213, 0.213) | 0.149 (0.042, 0.372) | NA (NA, NA) | 0.174 (0.07, 0.734) | 0.156 (0.071, 0.412) | 0.19 (0.118, 0.331) | 0.176 (0.062, 0.635) | 0.222 (0.081, 1.215) | 0.222 (0.086, 0.455) | 0 (0, 0) | 0.143 (0.096, 0.371) | 0.141 (0.093, 0.252) | 0.161 (0.089, 0.855) | NA (NA, NA) | 0.156 (0.067, 0.185) | 0.087 (0.087, 0.087) | 0.088 (0.088, 0.088) | 4.218 (4.218, 4.218) | 0.112 (0.112, 0.112) | NA (NA, NA) |
| all | TC5 | count | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 |
| all | TC5 | time | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) | 24 (10, 34) |
| all | TC5 | n | 10 (6, 54) | 8 (6, 14) | 1 (0, 2) | 4 (2, 6) | 4 (2, 14) | 6 (4, 11) | 2 (0, 3) | 6 (2, 8) | 5 (0, 8) | 0 (0, 0) | 2 (0, 6) | 0 (0, 3) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 2) | 1 (0, 3) | 0 (0, 1) | 2 (0, 4) | 1 (0, 2) | 0 (0, 2) | 0 (0, 0) | 3 (0, 6) | 4 (2, 8) | 2 (0, 6) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | post_p | 0.11 (0.03, 0.39) | 0.28 (0.1, 0.46) | 0.44 (0.38, 0.48) | 0.32 (0.18, 0.48) | 0.33 (0.2, 0.41) | 0.32 (0.11, 0.45) | 0.4 (0.2, 0.47) | 0.34 (0.19, 0.45) | 0.36 (0.09, 0.47) | NA (NA, NA) | 0.32 (0.24, 0.43) | 0.47 (0.44, 0.49) | NA (NA, NA) | 0.44 (0.3, 0.49) | NA (NA, NA) | 0.41 (0.33, 0.47) | 0.42 (0.35, 0.47) | 0.45 (0.4, 0.48) | 0.38 (0.29, 0.45) | 0.42 (0.36, 0.49) | 0.48 (0.41, 0.49) | NA (NA, NA) | 0.3 (0.16, 0.42) | 0.25 (0.12, 0.43) | 0.35 (0.23, 0.45) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | rate | 0.142 (0.093, 0.286) | 0.135 (0.088, 0.24) | 0.237 (0.1, 0.744) | 0.156 (0.094, 0.424) | 0.14 (0.1, 0.326) | 0.144 (0.081, 0.264) | 0.152 (0.091, 0.293) | 0.123 (0.087, 0.518) | 0.141 (0.096, 0.317) | NA (NA, NA) | 0.228 (0.098, 0.696) | 0.12 (0.047, 0.258) | NA (NA, NA) | 0.216 (0, 0.696) | 0.122 (0.122, 0.122) | 0.199 (0.079, 1.024) | 0.126 (0.091, 0.547) | 0.242 (0.089, 0.676) | 0.229 (0.092, 0.565) | 0.22 (0.061, 1.261) | 0.224 (0.004, 0.788) | 0 (0, 0) | 0.165 (0.117, 0.535) | 0.162 (0.087, 0.367) | 0.159 (0.091, 0.961) | NA (NA, NA) | 0 (0, 0.108) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| AR- & TP53- | TC1 | count | 250 | 250 | 250 | 250 | 250 | 250 | 250 | 250 | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | time | 18 (7, 32) | 18 (7, 32) | 18 (7, 32) | 18 (7, 32) | 18 (7, 32) | 18 (7, 32) | 18 (7, 32) | 18 (7, 32) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | n | 22 (15, 53) | 6 (2, 15) | 2 (0, 4) | 3 (1, 8) | 4 (0, 15) | 0 (0, 0) | 3 (0, 7) | 1 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | post_p | 0.13 (0.01, 0.39) | 0.36 (0.13, 0.48) | 0.43 (0.32, 0.49) | 0.4 (0.21, 0.48) | 0.37 (0.17, 0.48) | 0.47 (0.44, 0.49) | 0.41 (0.24, 0.49) | 0.43 (0.28, 0.49) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | rate | 0.119 (0.092, 0.156) | 0.136 (0.082, 0.305) | 0.147 (0, 0.485) | 0.145 (0.075, 0.467) | 0.141 (0.087, 0.389) | 10.787 (0.469, 75.756) | 0.144 (0.076, 0.456) | 0.166 (0, 0.579) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | count | 232 | 232 | 232 | 232 | 232 | 232 | 232 | 232 | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | time | 22 (12, 33) | 22 (12, 33) | 22 (12, 33) | 22 (12, 33) | 22 (12, 33) | 22 (12, 33) | 22 (12, 33) | 22 (12, 33) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | n | 19 (8, 63) | 7 (3, 17) | 2 (0, 4) | 3 (1, 9) | 7 (4, 16) | 0 (0, 0) | 4 (1, 9) | 2 (0, 4) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | post_p | 0.16 (0.03, 0.43) | 0.32 (0.12, 0.47) | 0.44 (0.31, 0.49) | 0.39 (0.23, 0.48) | 0.31 (0.12, 0.46) | NA (NA, NA) | 0.36 (0.16, 0.48) | 0.42 (0.27, 0.48) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | rate | 0.116 (0.092, 0.171) | 0.133 (0.09, 0.35) | 0.146 (0.063, 0.462) | 0.154 (0.093, 0.447) | 0.131 (0.089, 0.28) | 0 (0, 0.244) | 0.156 (0.09, 0.489) | 0.176 (0.08, 0.505) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | count | 213 | 213 | 213 | 213 | 213 | 213 | 213 | 213 | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | time | 21 (12, 33) | 21 (12, 33) | 21 (12, 33) | 21 (12, 33) | 21 (12, 33) | 21 (12, 33) | 21 (12, 33) | 21 (12, 33) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | n | 17 (7, 68) | 6 (2, 21) | 1 (0, 4) | 3 (1, 8) | 7 (4, 16) | 0 (0, 0) | 4 (2, 7) | 2 (0, 4) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | post_p | 0.2 (0.02, 0.44) | 0.34 (0.12, 0.47) | 0.42 (0.29, 0.49) | 0.4 (0.23, 0.49) | 0.33 (0.1, 0.47) | NA (NA, NA) | 0.38 (0.21, 0.49) | 0.43 (0.31, 0.49) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | rate | 0.122 (0.093, 0.204) | 0.131 (0.088, 0.382) | 0.168 (0.059, 0.645) | 0.142 (0.08, 0.459) | 0.127 (0.083, 0.253) | 0.079 (0, 0.279) | 0.148 (0.083, 0.415) | 0.154 (0.07, 0.686) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | count | 245 | 245 | 245 | 245 | 245 | 245 | 245 | 245 | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | time | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | n | 16 (7, 71) | 8 (4, 16) | 1 (0, 4) | 4 (2, 9) | 6 (2, 17) | 0 (0, 0) | 3 (1, 8) | 1 (0, 4) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | post_p | 0.16 (0.02, 0.43) | 0.28 (0.11, 0.47) | 0.43 (0.32, 0.48) | 0.36 (0.19, 0.49) | 0.34 (0.13, 0.47) | 0.47 (0.47, 0.47) | 0.39 (0.22, 0.48) | 0.43 (0.3, 0.49) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | rate | 0.125 (0.092, 0.244) | 0.125 (0.091, 0.246) | 0.17 (0.076, 0.692) | 0.143 (0.086, 0.386) | 0.138 (0.093, 0.336) | 1.355 (0.621, 2.089) | 0.163 (0.089, 0.589) | 0.151 (0.067, 0.578) | ||||||||||||||||||||||||
| HRD+ | TC1 | count | 53 | 53 | 53 | 53 | 53 | 53 | 53 | 53 | 53 | 53 | 53 | 53 | 53 | 53 | 53 | 53 | ||||||||||||||||
| HRD+ | TC1 | time | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | 32 (24, 35) | ||||||||||||||||
| HRD+ | TC1 | n | 15 (7, 23) | 0 (0, 0) | 6 (3, 11) | 2 (0, 4) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 4) | 3 (1, 6) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | post_p | 0.3 (0.1, 0.48) | NA (NA, NA) | 0.37 (0.2, 0.46) | 0.4 (0.3, 0.49) | NA (NA, NA) | 0.43 (0.34, 0.49) | NA (NA, NA) | 0.4 (0.32, 0.47) | 0.37 (0.2, 0.48) | NA (NA, NA) | 0.45 (0.39, 0.48) | NA (NA, NA) | 0.41 (0.41, 0.41) | NA (NA, NA) | NA (NA, NA) | 0.4 (0.4, 0.4) | ||||||||||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | rate | 0.115 (0.087, 0.181) | 0.202 (0.202, 0.202) | 0.125 (0.08, 0.176) | 0.175 (0.089, 0.465) | 0.326 (0.188, 0.464) | 0.166 (0.085, 0.655) | 0.114 (0.023, 0.206) | 0.181 (0.084, 0.505) | 0.169 (0.082, 0.591) | 0.113 (0.088, 0.943) | 0.138 (0, 1.605) | NA (NA, NA) | 0.127 (0, 0.489) | NA (NA, NA) | 5.852 (5.852, 5.852) | 0.071 (0.014, 0.145) | ||||||||||||||||
| HRD+ | TC3 | count | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | ||||||||||||||||
| HRD+ | TC3 | time | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | 27 (20, 35) | ||||||||||||||||
| HRD+ | TC3 | n | 12 (6, 18) | 0 (0, 0) | 6 (3, 10) | 2 (1, 6) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 2 (0, 4) | 4 (2, 7) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC3 | post_p | 0.31 (0.09, 0.45) | NA (NA, NA) | 0.36 (0.17, 0.48) | 0.43 (0.28, 0.49) | NA (NA, NA) | 0.44 (0.31, 0.48) | 0.48 (0.48, 0.48) | 0.44 (0.35, 0.48) | 0.38 (0.23, 0.48) | NA (NA, NA) | 0.42 (0.39, 0.47) | NA (NA, NA) | 0.44 (0.44, 0.44) | 0.47 (0.47, 0.47) | NA (NA, NA) | 0.45 (0.45, 0.45) | ||||||||||||||||
| HRD+ | TC3 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| HRD+ | TC3 | rate | 0.118 (0.09, 0.209) | 4.187 (0, 23.441) | 0.128 (0.097, 0.261) | 0.165 (0.084, 0.475) | 0.457 (0.457, 0.457) | 0.183 (0.082, 0.856) | 0.089 (0, 1.611) | 0.154 (0.064, 0.727) | 0.131 (0.084, 0.305) | NA (NA, NA) | 0.162 (0, 0.381) | NA (NA, NA) | 0.14 (0, 0.455) | 0.182 (0.135, 1.041) | 0.466 (0.101, 0.841) | 0.305 (0.199, 0.927) | ||||||||||||||||
| HRD+ | TC4 | count | 102 | 102 | 102 | 102 | 102 | 102 | 102 | 102 | 102 | 102 | 102 | 102 | 102 | 102 | 102 | 102 | ||||||||||||||||
| HRD+ | TC4 | time | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | 30 (22, 34) | ||||||||||||||||
| HRD+ | TC4 | n | 12 (7, 20) | 0 (0, 0) | 6 (3, 11) | 2 (1, 6) | 0 (0, 0) | 1 (0, 4) | 0 (0, 0) | 2 (0, 4) | 4 (2, 8) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC4 | post_p | 0.31 (0.1, 0.47) | NA (NA, NA) | 0.36 (0.17, 0.48) | 0.4 (0.28, 0.49) | NA (NA, NA) | 0.42 (0.31, 0.49) | NA (NA, NA) | 0.41 (0.34, 0.47) | 0.35 (0.21, 0.48) | NA (NA, NA) | 0.44 (0.38, 0.48) | 0.44 (0.44, 0.44) | 0.44 (0.41, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC4 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| HRD+ | TC4 | rate | 0.114 (0.085, 0.179) | 0.076 (0.015, 0.216) | 0.131 (0.087, 0.289) | 0.146 (0.073, 0.374) | 0.88 (0.204, 2.496) | 0.166 (0.062, 0.586) | 0.103 (0.083, 1.165) | 0.166 (0.072, 0.748) | 0.141 (0.085, 0.466) | 0.534 (0.207, 0.867) | 0.151 (0.048, 0.604) | 0.313 (0.052, 0.984) | 0.368 (0.107, 1.419) | 0.057 (0.011, 0.061) | 0.183 (0.077, 0.289) | 0 (0, 0.158) | ||||||||||||||||
| HRD+ | TC5 | count | 62 | 62 | 62 | 62 | 62 | 62 | 62 | 62 | 62 | 62 | 62 | 62 | 62 | 62 | 62 | 62 | ||||||||||||||||
| HRD+ | TC5 | time | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | 31 (25, 36) | ||||||||||||||||
| HRD+ | TC5 | n | 15 (6, 24) | 0 (0, 0) | 6 (3, 13) | 2 (0, 4) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 1 (0, 3) | 3 (1, 6) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC5 | post_p | 0.29 (0.11, 0.45) | 0.49 (0.49, 0.49) | 0.38 (0.26, 0.48) | 0.43 (0.24, 0.49) | NA (NA, NA) | 0.41 (0.36, 0.49) | 0.49 (0.49, 0.49) | 0.4 (0.3, 0.49) | 0.35 (0.2, 0.48) | NA (NA, NA) | 0.42 (0.35, 0.45) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC5 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC5 | rate | 0.116 (0.087, 0.198) | 0 (0, 0) | 0.128 (0.091, 0.225) | 0.151 (0.083, 0.505) | 1.871 (1.452, 2.291) | 0.21 (0.052, 0.921) | 0.18 (0.036, 0.323) | 0.18 (0.076, 0.42) | 0.159 (0.09, 0.485) | 0.071 (0.071, 0.071) | 0.321 (0.1, 1.077) | NA (NA, NA) | 0.115 (0, 1.638) | 0.17 (0.17, 0.17) | 0.076 (0.015, 0.144) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC1 | count | 182 | 182 | 182 | 182 | 182 | 182 | 182 | 182 | 182 | 182 | 182 | 182 | 182 | 182 | 182 | 182 | ||||||||||||||||
| TP53+ | TC1 | time | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | 24 (15, 34) | ||||||||||||||||
| TP53+ | TC1 | n | 8 (4, 16) | 6 (3, 14) | 3 (1, 5) | 5 (2, 12) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 3) | 0 (0, 2) | 0 (0, 0) | 6 (2, 13) | 4 (2, 11) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | post_p | 0.31 (0.13, 0.46) | 0.28 (0.11, 0.46) | 0.4 (0.25, 0.48) | 0.32 (0.15, 0.48) | NA (NA, NA) | 0.43 (0.31, 0.49) | NA (NA, NA) | 0.45 (0.34, 0.48) | 0.45 (0.39, 0.49) | NA (NA, NA) | 0.33 (0.12, 0.46) | 0.35 (0.18, 0.48) | 0.47 (0.46, 0.49) | NA (NA, NA) | NA (NA, NA) | 0.38 (0.38, 0.38) | ||||||||||||||||
| TP53+ | TC1 | r_prob | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | rate | 0.123 (0.083, 0.221) | 0.143 (0.094, 0.298) | 0.166 (0.082, 0.446) | 0.143 (0.088, 0.384) | 0.174 (0.035, 0.576) | 0.159 (0, 0.963) | 0.853 (0.171, 1.536) | 0.136 (0, 0.502) | 0.184 (0, 0.942) | 0.315 (0.063, 0.567) | 0.142 (0.092, 0.395) | 0.141 (0.084, 0.46) | 0.072 (0, 0.803) | 0.4 (0.124, 0.727) | 0.36 (0.168, 2.724) | 0.071 (0.071, 0.071) | ||||||||||||||||
| TP53+ | TC3 | count | 156 | 156 | 156 | 156 | 156 | 156 | 156 | 156 | 156 | 156 | 156 | 156 | 156 | 156 | 156 | 156 | ||||||||||||||||
| TP53+ | TC3 | time | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | ||||||||||||||||
| TP53+ | TC3 | n | 6 (3, 14) | 7 (3, 13) | 2 (0, 5) | 4 (2, 10) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 3) | 0 (0, 2) | 0 (0, 0) | 5 (2, 11) | 4 (2, 10) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC3 | post_p | 0.32 (0.14, 0.48) | 0.33 (0.14, 0.48) | 0.39 (0.25, 0.48) | 0.35 (0.19, 0.47) | NA (NA, NA) | 0.42 (0.33, 0.49) | 0.46 (0.46, 0.46) | 0.45 (0.33, 0.48) | 0.45 (0.38, 0.49) | NA (NA, NA) | 0.33 (0.15, 0.47) | 0.32 (0.18, 0.47) | 0.44 (0.42, 0.46) | 0.49 (0.49, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC3 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC3 | rate | 0.127 (0.087, 0.252) | 0.126 (0.088, 0.283) | 0.174 (0.086, 0.658) | 0.145 (0.094, 0.413) | 0.054 (0, 0.693) | 0.186 (0.045, 0.737) | 0.122 (0, 2.967) | 0.167 (0.049, 0.652) | 0.165 (0, 0.423) | 0.182 (0.017, 0.428) | 0.14 (0.084, 0.311) | 0.149 (0.093, 0.353) | 0.129 (0, 0.769) | 0.182 (0, 0.644) | 0.064 (0, 0.67) | 0.153 (0.044, 0.261) | ||||||||||||||||
| TP53+ | TC4 | count | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 | ||||||||||||||||
| TP53+ | TC4 | time | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | ||||||||||||||||
| TP53+ | TC4 | n | 7 (4, 17) | 6 (3, 16) | 2 (0, 5) | 4 (2, 11) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 3) | 0 (0, 2) | 0 (0, 0) | 6 (2, 14) | 5 (2, 9) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC4 | post_p | 0.31 (0.11, 0.47) | 0.33 (0.14, 0.47) | 0.43 (0.26, 0.49) | 0.34 (0.17, 0.48) | NA (NA, NA) | 0.41 (0.27, 0.49) | NA (NA, NA) | 0.43 (0.32, 0.48) | 0.44 (0.39, 0.48) | NA (NA, NA) | 0.35 (0.16, 0.46) | 0.34 (0.16, 0.48) | 0.46 (0.42, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC4 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC4 | rate | 0.126 (0.086, 0.241) | 0.13 (0.085, 0.27) | 0.15 (0.06, 0.434) | 0.147 (0.091, 0.486) | 0.152 (0, 0.248) | 0.16 (0.053, 0.604) | 0.087 (0.014, 0.192) | 0.163 (0.062, 0.701) | 0.161 (0, 0.721) | 0 (0, 0.373) | 0.129 (0.09, 0.345) | 0.149 (0.092, 0.328) | 0.355 (0.026, 1.083) | 0.065 (0.046, 2.579) | 0 (0, 0.199) | 0.565 (0.401, 0.729) | ||||||||||||||||
| TP53+ | TC5 | count | 177 | 177 | 177 | 177 | 177 | 177 | 177 | 177 | 177 | 177 | 177 | 177 | 177 | 177 | 177 | 177 | ||||||||||||||||
| TP53+ | TC5 | time | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | 23 (13, 34) | ||||||||||||||||
| TP53+ | TC5 | n | 6 (3, 15) | 7 (3, 13) | 2 (0, 5) | 6 (3, 10) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 1 (0, 2) | 0 (0, 1) | 0 (0, 0) | 4 (2, 10) | 4 (2, 11) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | post_p | 0.32 (0.11, 0.47) | 0.3 (0.13, 0.46) | 0.41 (0.25, 0.48) | 0.34 (0.14, 0.47) | NA (NA, NA) | 0.44 (0.31, 0.49) | NA (NA, NA) | 0.44 (0.29, 0.49) | 0.47 (0.41, 0.5) | NA (NA, NA) | 0.33 (0.14, 0.47) | 0.35 (0.15, 0.48) | 0.45 (0.44, 0.49) | 0.48 (0.48, 0.48) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC5 | r_prob | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | rate | 0.138 (0.087, 0.301) | 0.135 (0.087, 0.292) | 0.159 (0.086, 0.578) | 0.132 (0.08, 0.25) | 0.113 (0.089, 0.211) | 0.195 (0, 1.361) | 0.181 (0.037, 0.298) | 0.16 (0, 0.486) | 0.167 (0, 0.987) | 0.064 (0.013, 0.088) | 0.145 (0.093, 0.432) | 0.137 (0.084, 0.37) | 0.079 (0, 0.78) | 0 (0, 0.101) | 0.076 (0, 0.572) | 0.223 (0.223, 0.223) | ||||||||||||||||
| TEfus+ | TC1 | count | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | ||||||||||||||||
| TEfus+ | TC1 | time | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | 27 (17, 35) | ||||||||||||||||
| TEfus+ | TC1 | n | 2 (0, 5) | 3 (1, 8) | 2 (1, 5) | 5 (2, 11) | 4 (0, 10) | 1 (0, 3) | 0 (0, 0) | 1 (0, 3) | 2 (1, 5) | 2 (0, 3) | 4 (2, 11) | 4 (1, 8) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | post_p | 0.42 (0.26, 0.49) | 0.35 (0.16, 0.45) | 0.4 (0.26, 0.48) | 0.31 (0.16, 0.47) | 0.36 (0.19, 0.49) | 0.42 (0.3, 0.48) | NA (NA, NA) | 0.44 (0.34, 0.47) | 0.37 (0.24, 0.47) | 0.42 (0.33, 0.47) | 0.27 (0.12, 0.44) | 0.35 (0.17, 0.46) | 0.45 (0.36, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | rate | 0.147 (0.071, 0.424) | 0.149 (0.099, 0.544) | 0.164 (0.084, 0.5) | 0.138 (0.087, 0.344) | 0.132 (0.084, 0.319) | 0.182 (0.077, 0.576) | 0.168 (0.119, 0.217) | 0.122 (0.03, 0.457) | 0.168 (0.095, 0.461) | 0.182 (0.055, 0.686) | 0.146 (0.097, 0.488) | 0.147 (0.092, 0.451) | 0.191 (0, 0.618) | 0.091 (0.091, 0.091) | NA (NA, NA) | 0.197 (0.096, 0.298) | ||||||||||||||||
| TEfus+ | TC3 | count | 72 | 72 | 72 | 72 | 72 | 72 | 72 | 72 | 72 | 72 | 72 | 72 | 72 | 72 | 72 | 72 | ||||||||||||||||
| TEfus+ | TC3 | time | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | ||||||||||||||||
| TEfus+ | TC3 | n | 1 (0, 4) | 3 (1, 8) | 2 (0, 5) | 4 (2, 9) | 4 (1, 9) | 2 (0, 4) | 0 (0, 0) | 1 (0, 3) | 3 (1, 5) | 1 (0, 3) | 5 (2, 10) | 4 (2, 9) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC3 | post_p | 0.44 (0.29, 0.48) | 0.35 (0.19, 0.48) | 0.38 (0.18, 0.47) | 0.34 (0.18, 0.47) | 0.37 (0.16, 0.48) | 0.42 (0.32, 0.48) | NA (NA, NA) | 0.44 (0.38, 0.48) | 0.41 (0.27, 0.49) | 0.42 (0.3, 0.47) | 0.32 (0.14, 0.46) | 0.3 (0.14, 0.47) | 0.44 (0.41, 0.48) | NA (NA, NA) | NA (NA, NA) | 0.41 (0.41, 0.41) | ||||||||||||||||
| TEfus+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC3 | rate | 0.169 (0.078, 0.569) | 0.159 (0.094, 0.443) | 0.183 (0.096, 0.515) | 0.157 (0.097, 0.413) | 0.141 (0.084, 0.295) | 0.17 (0.077, 0.505) | 0 (0, 0) | 0.168 (0.059, 0.751) | 0.133 (0.075, 0.358) | 0.156 (0.052, 0.388) | 0.133 (0.084, 0.277) | 0.159 (0.093, 0.39) | 0.194 (0, 0.733) | 0.122 (0.122, 0.122) | 0.138 (0.028, 0.655) | 0.305 (0.188, 0.927) | ||||||||||||||||
| TEfus+ | TC4 | count | 69 | 69 | 69 | 69 | 69 | 69 | 69 | 69 | 69 | 69 | 69 | 69 | 69 | 69 | 69 | 69 | ||||||||||||||||
| TEfus+ | TC4 | time | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | 26 (16, 35) | ||||||||||||||||
| TEfus+ | TC4 | n | 1 (0, 4) | 3 (1, 8) | 2 (0, 5) | 4 (2, 8) | 4 (2, 7) | 2 (0, 5) | 0 (0, 0) | 1 (0, 3) | 2 (1, 6) | 1 (0, 3) | 6 (2, 14) | 4 (1, 7) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC4 | post_p | 0.43 (0.32, 0.48) | 0.37 (0.24, 0.46) | 0.41 (0.3, 0.48) | 0.35 (0.18, 0.48) | 0.38 (0.22, 0.48) | 0.42 (0.28, 0.49) | NA (NA, NA) | 0.44 (0.37, 0.49) | 0.39 (0.26, 0.48) | 0.43 (0.31, 0.49) | 0.33 (0.15, 0.47) | 0.32 (0.17, 0.46) | 0.46 (0.4, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC4 | rate | 0.201 (0.102, 1.069) | 0.144 (0.088, 0.933) | 0.156 (0.096, 0.47) | 0.13 (0.079, 0.378) | 0.146 (0.076, 0.407) | 0.148 (0.059, 0.366) | NA (NA, NA) | 0.174 (0.076, 0.539) | 0.165 (0.073, 0.862) | 0.162 (0.073, 0.59) | 0.122 (0.084, 0.297) | 0.169 (0.1, 0.476) | 0.121 (0, 0.245) | 0.2 (0.109, 0.29) | 0.112 (0.022, 0.275) | 0.385 (0.077, 0.693) | ||||||||||||||||
| TEfus+ | TC5 | count | 92 | 92 | 92 | 92 | 92 | 92 | 92 | 92 | 92 | 92 | 92 | 92 | 92 | 92 | 92 | 92 | ||||||||||||||||
| TEfus+ | TC5 | time | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | 24 (17, 35) | ||||||||||||||||
| TEfus+ | TC5 | n | 1 (0, 4) | 4 (2, 7) | 2 (0, 4) | 6 (3, 10) | 3 (1, 9) | 1 (0, 4) | 0 (0, 0) | 0 (0, 2) | 2 (1, 5) | 1 (0, 3) | 5 (2, 11) | 4 (3, 10) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | post_p | 0.41 (0.3, 0.47) | 0.32 (0.18, 0.47) | 0.41 (0.28, 0.48) | 0.31 (0.15, 0.46) | 0.38 (0.23, 0.47) | 0.44 (0.3, 0.48) | NA (NA, NA) | 0.44 (0.31, 0.49) | 0.39 (0.21, 0.48) | 0.41 (0.33, 0.47) | 0.33 (0.13, 0.46) | 0.32 (0.13, 0.44) | 0.46 (0.41, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | rate | 0.186 (0.092, 0.849) | 0.163 (0.09, 0.457) | 0.16 (0.091, 0.813) | 0.131 (0.09, 0.268) | 0.189 (0.096, 0.788) | 0.138 (0.077, 0.484) | 0.222 (0.142, 0.302) | 0.177 (0, 0.44) | 0.195 (0.089, 0.625) | 0.264 (0.067, 1.577) | 0.128 (0.087, 0.377) | 0.144 (0.096, 0.283) | 0.109 (0, 0.887) | NA (NA, NA) | 0.076 (0.076, 0.076) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | count | 125 | 125 | 125 | 125 | 125 | 125 | 125 | 125 | 125 | 125 | 125 | 125 | 125 | 125 | 125 | 125 | ||||||||||||||||
| PI3K+ | TC1 | time | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | 25 (16, 35) | ||||||||||||||||
| PI3K+ | TC1 | n | 7 (3, 21) | 4 (1, 9) | 7 (3, 14) | 6 (3, 12) | 0 (0, 0) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 2) | 1 (0, 4) | 0 (0, 0) | 5 (1, 11) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | post_p | 0.28 (0.11, 0.46) | 0.36 (0.18, 0.47) | 0.26 (0.13, 0.46) | 0.33 (0.15, 0.45) | NA (NA, NA) | 0.42 (0.29, 0.49) | 0.45 (0.33, 0.49) | 0.44 (0.34, 0.48) | 0.42 (0.35, 0.48) | 0.43 (0.31, 0.48) | NA (NA, NA) | 0.33 (0.17, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | r_prob | 0.22 (0.22, 0.22) | 0.22 (0.22, 0.22) | 0.13 (0.13, 0.13) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.14 (0.14, 0.14) | 0.14 (0.14, 0.14) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | rate | 0.128 (0.085, 0.227) | 0.156 (0.081, 0.388) | 0.135 (0.09, 0.3) | 0.136 (0.094, 0.319) | 20.482 (20.482, 20.482) | 0.159 (0.049, 0.653) | 0.196 (0, 1.187) | 0.162 (0.053, 1.088) | 0.205 (0, 0.695) | 0.163 (0.055, 0.73) | 0.044 (0.009, 0.079) | 0.143 (0.086, 0.421) | 0 (0, 0.449) | 0.046 (0.009, 0.082) | 0.498 (0.391, 0.606) | 0.095 (0.019, 0.172) | ||||||||||||||||
| PI3K+ | TC3 | count | 113 | 113 | 113 | 113 | 113 | 113 | 113 | 113 | 113 | 113 | 113 | 113 | 113 | 113 | 113 | 113 | ||||||||||||||||
| PI3K+ | TC3 | time | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | ||||||||||||||||
| PI3K+ | TC3 | n | 7 (2, 18) | 4 (1, 9) | 7 (3, 15) | 5 (2, 10) | 0 (0, 0) | 2 (0, 4) | 1 (0, 3) | 1 (0, 4) | 1 (0, 2) | 1 (0, 3) | 0 (0, 0) | 4 (2, 9) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC3 | post_p | 0.3 (0.1, 0.45) | 0.33 (0.18, 0.46) | 0.3 (0.13, 0.46) | 0.35 (0.16, 0.48) | NA (NA, NA) | 0.41 (0.29, 0.47) | 0.42 (0.3, 0.48) | 0.44 (0.35, 0.49) | 0.45 (0.36, 0.49) | 0.42 (0.32, 0.48) | NA (NA, NA) | 0.32 (0.18, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.44 (0.44, 0.44) | ||||||||||||||||
| PI3K+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC3 | rate | 0.13 (0.095, 0.332) | 0.154 (0.103, 0.466) | 0.132 (0.088, 0.271) | 0.142 (0.085, 0.33) | 0.202 (0.123, 0.454) | 0.164 (0.083, 0.433) | 0.183 (0.066, 0.716) | 0.147 (0.054, 0.438) | 0.133 (0, 0.659) | 0.188 (0.03, 0.594) | 0.182 (0.017, 0.428) | 0.148 (0.093, 0.384) | NA (NA, NA) | 0.168 (0.168, 0.168) | 0.152 (0.129, 0.176) | 1.082 (1.082, 1.082) | ||||||||||||||||
| PI3K+ | TC4 | count | 122 | 122 | 122 | 122 | 122 | 122 | 122 | 122 | 122 | 122 | 122 | 122 | 122 | 122 | 122 | 122 | ||||||||||||||||
| PI3K+ | TC4 | time | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | 25 (17, 35) | ||||||||||||||||
| PI3K+ | TC4 | n | 7 (3, 22) | 4 (1, 10) | 6 (3, 14) | 5 (2, 10) | 0 (0, 0) | 2 (1, 5) | 1 (0, 3) | 1 (0, 3) | 1 (0, 2) | 1 (0, 3) | 0 (0, 0) | 4 (2, 8) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC4 | post_p | 0.3 (0.13, 0.46) | 0.39 (0.21, 0.48) | 0.33 (0.13, 0.45) | 0.34 (0.15, 0.47) | NA (NA, NA) | 0.41 (0.28, 0.49) | 0.42 (0.3, 0.49) | 0.42 (0.3, 0.48) | 0.43 (0.36, 0.47) | 0.41 (0.33, 0.48) | NA (NA, NA) | 0.33 (0.16, 0.46) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC4 | rate | 0.128 (0.088, 0.342) | 0.144 (0.084, 0.339) | 0.13 (0.095, 0.257) | 0.143 (0.09, 0.469) | 0.164 (0, 0.287) | 0.162 (0.073, 0.674) | 0.177 (0.065, 0.631) | 0.165 (0.065, 0.731) | 0.234 (0.055, 1.522) | 0.164 (0.073, 0.581) | 0 (0, 0.105) | 0.154 (0.095, 0.384) | 0.415 (0.116, 0.704) | 0.34 (0.154, 0.828) | 0 (0, 3.375) | 0.565 (0.345, 1.318) | ||||||||||||||||
| PI3K+ | TC5 | count | 172 | 172 | 172 | 172 | 172 | 172 | 172 | 172 | 172 | 172 | 172 | 172 | 172 | 172 | 172 | 172 | ||||||||||||||||
| PI3K+ | TC5 | time | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | 19 (10, 33) | ||||||||||||||||
| PI3K+ | TC5 | n | 8 (5, 16) | 4 (2, 9) | 7 (3, 13) | 6 (3, 10) | 0 (0, 0) | 1 (0, 4) | 0 (0, 2) | 0 (0, 2) | 1 (0, 2) | 1 (0, 4) | 0 (0, 0) | 4 (2, 11) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | post_p | 0.29 (0.09, 0.46) | 0.37 (0.17, 0.47) | 0.31 (0.13, 0.48) | 0.34 (0.15, 0.47) | 0.46 (0.45, 0.48) | 0.43 (0.32, 0.49) | 0.44 (0.31, 0.49) | 0.44 (0.33, 0.49) | 0.44 (0.38, 0.49) | 0.44 (0.31, 0.47) | NA (NA, NA) | 0.36 (0.19, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC5 | r_prob | 0.38 (0.38, 0.38) | 0.38 (0.38, 0.38) | 0.33 (0.33, 0.33) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | rate | 0.127 (0.088, 0.219) | 0.149 (0.081, 0.444) | 0.126 (0.085, 0.315) | 0.131 (0.082, 0.243) | 1.136 (0.227, 2.045) | 0.165 (0.085, 0.567) | 0.213 (0, 1.321) | 0.139 (0, 0.413) | 0.15 (0, 0.593) | 0.217 (0.06, 1.093) | 0.145 (0, 0.648) | 0.144 (0.084, 0.296) | 0.071 (0.014, 0.192) | 0 (0, 0) | NA (NA, NA) | 0.174 (0.135, 0.213) |