Simulation scenario 2, CR phase

Setting description

TC2 more effective in all the biomarker signatures

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4	TC5
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
all	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
all	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
AR- & TP53-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
AR- & TP53-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
AR- & TP53-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
HRD+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
HRD+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
TP53+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
TP53+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
TEfus+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
TEfus+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
PI3K+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
PI3K+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
PI3K+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4	TC5
—–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 3 225 0 2 1 AR- & TP53- 4 325 2 4 2 HRD+ 2 40 0 2 1 TP53+ 0 219 0 0 0 TEfus+ 1 146 0 0 1 PI3K+ 0 173 0 0 0

TC1 TC2 TC3 TC4 TC5 all 0.006 0.450 0.000 0.004 0.002 AR- & TP53- 0.008 0.650 0.004 0.008 0.004 HRD+ 0.004 0.080 0.000 0.004 0.002 TP53+ 0.000 0.438 0.000 0.000 0.000 TEfus+ 0.002 0.292 0.000 0.000 0.002 PI3K+ 0.000 0.346 0.000 0.000 0.000

futility (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 37 0 17 23 26 AR- & TP53- 250 0 232 213 245 HRD+ 53 0 96 102 62 TP53+ 182 0 156 165 177 TEfus+ 78 0 72 69 92 PI3K+ 125 0 113 122 172

TC1 TC2 TC3 TC4 TC5 all 0.074 0 0.034 0.046 0.052 AR- & TP53- 0.500 0 0.464 0.426 0.490 HRD+ 0.106 0 0.192 0.204 0.124 TP53+ 0.364 0 0.312 0.330 0.354 TEfus+ 0.156 0 0.144 0.138 0.184 PI3K+ 0.250 0 0.226 0.244 0.344

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 0 0 AR- & TP53- 39 71 78 65 61 HRD+ 0 0 0 0 0 TP53+ 0 0 0 0 0 TEfus+ 0 0 0 0 0 PI3K+ 0 0 0 0 0

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.000 0.00 0.000 AR- & TP53- 0.078 0.142 0.156 0.13 0.122 HRD+ 0.000 0.000 0.000 0.00 0.000 TP53+ 0.000 0.000 0.000 0.00 0.000 TEfus+ 0.000 0.000 0.000 0.00 0.000 PI3K+ 0.000 0.000 0.000 0.00 0.000

Operating characteristics

char	overall	TC1	TC2	TC3	TC4	TC5
err_sign	0.544	0.02	0.524	0.004	0.016	0.01
err_type	0.048	0.02	0.000	0.004	0.016	0.01
pow_sign	0.450	0.00	0.450	0.000	0.000	0.00
pow_type	0.974	0.00	0.974	0.000	0.000	0.00

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4	TC5
all	graduation	0	3	225	0	2	1
all	futility	0	37	0	17	23	26
all	max_n	0	0	0	0	0	0
all	n	409 (373, 444)	139 (84, 214)	116 (33, 226)	154 (92, 230)	150 (94, 226)	144 (84, 228)
all	n_unique	382 (349, 414)	128 (78, 202)	106 (30, 215)	141 (84, 214)	137 (86, 213)	133 (77, 211)
all	time_trial	36 (36, 36)	36 (36, 36)	36 (6, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
all	time_stop	NA (NA, NA)	14 (3, 31)	10 (5, 28)	28 (11, 35)	24 (8, 35)	23 (8, 34)
all	post_p	NA (NA, NA)	0 (0, 0.02)	1 (1, 1)	0 (0, 0.01)	0 (0, 0.01)	0 (0, 0.01)
all	rate	0.076 (0.071, 0.083)	0.114 (0.1, 0.131)	0.038 (0.032, 0.045)	0.114 (0.101, 0.129)	0.114 (0.102, 0.128)	0.114 (0.101, 0.13)
AR- & TP53-	graduation	0	4	325	2	4	2
AR- & TP53-	futility	0	250	0	232	213	245
AR- & TP53-	max_n	0	39	71	78	65	61
AR- & TP53-	n	246 (215, 272)	68 (27, 148)	34 (17, 152)	78 (32, 152)	80 (29, 151)	72 (30, 151)
AR- & TP53-	n_unique	231 (200, 256)	63 (26, 138)	31 (16, 144)	73 (29, 143)	73 (26, 143)	66 (27, 142)
AR- & TP53-	time_trial	36 (36, 36)	35 (9, 36)	18 (8, 36)	36 (15, 36)	36 (15, 36)	36 (15, 36)
AR- & TP53-	time_stop	NA (NA, NA)	18 (7, 32)	11 (8, 25)	22 (12, 33)	21 (12, 32)	23 (13, 32)
AR- & TP53-	post_p	NA (NA, NA)	0.01 (0, 0.09)	1 (0.98, 1)	0.01 (0, 0.09)	0.01 (0, 0.11)	0.01 (0, 0.09)
AR- & TP53-	rate	0.076 (0.069, 0.084)	0.116 (0.098, 0.141)	0.038 (0.029, 0.048)	0.115 (0.098, 0.142)	0.115 (0.098, 0.14)	0.115 (0.098, 0.146)
HRD+	graduation	0	2	40	0	2	1
HRD+	futility	0	53	0	96	102	62
HRD+	max_n	0	0	0	0	0	0
HRD+	n	62 (49, 75)	25 (8, 44)	13 (2, 30)	29 (18, 47)	29 (19, 50)	25 (13, 44)
HRD+	n_unique	58 (45, 69)	22 (8, 41)	12 (2, 27)	27 (17, 44)	27 (18, 46)	23 (12, 41)
HRD+	time_trial	36 (36, 36)	36 (35, 36)	36 (36, 36)	36 (27, 36)	36 (29, 36)	36 (35, 36)
HRD+	time_stop	NA (NA, NA)	31 (23, 35)	28 (21, 35)	27 (20, 35)	30 (21, 34)	31 (23, 36)
HRD+	post_p	NA (NA, NA)	0.14 (0.02, 0.49)	0.97 (0.66, 1)	0.1 (0.01, 0.37)	0.1 (0.01, 0.36)	0.12 (0.01, 0.45)
HRD+	rate	0.076 (0.063, 0.094)	0.116 (0.086, 0.17)	0.038 (0.022, 0.065)	0.115 (0.092, 0.148)	0.115 (0.091, 0.15)	0.113 (0.089, 0.162)
TP53+	graduation	0	0	219	0	0	0
TP53+	futility	0	182	0	156	165	177
TP53+	max_n	0	0	0	0	0	0
TP53+	n	135 (119, 156)	53 (26, 85)	38 (13, 103)	54 (28, 87)	53 (28, 85)	53 (26, 85)
TP53+	n_unique	126 (109, 144)	49 (24, 78)	34 (12, 97)	48 (26, 80)	48 (26, 77)	48 (25, 79)
TP53+	time_trial	36 (36, 36)	36 (19, 36)	36 (14, 36)	36 (20, 36)	36 (21, 36)	36 (17, 36)
TP53+	time_stop	NA (NA, NA)	24 (15, 34)	18 (12, 29)	24 (16, 32)	25 (16, 34)	23 (13, 34)
TP53+	post_p	NA (NA, NA)	0.03 (0, 0.23)	1 (0.98, 1)	0.03 (0, 0.21)	0.03 (0, 0.21)	0.03 (0, 0.19)
TP53+	rate	0.076 (0.067, 0.089)	0.114 (0.095, 0.146)	0.038 (0.028, 0.048)	0.114 (0.095, 0.144)	0.116 (0.096, 0.146)	0.116 (0.095, 0.144)
TEfus+	graduation	0	1	146	0	0	1
TEfus+	futility	0	78	0	72	69	92
TEfus+	max_n	0	0	0	0	0	0
TEfus+	n	126 (109, 142)	52 (28, 79)	36 (12, 76)	54 (32, 81)	55 (33, 78)	53 (28, 79)
TEfus+	n_unique	116 (100, 133)	47 (25, 73)	34 (11, 70)	50 (29, 74)	50 (30, 72)	49 (26, 72)
TEfus+	time_trial	36 (36, 36)	36 (29, 36)	36 (16, 36)	36 (30, 36)	36 (30, 36)	36 (26, 36)
TEfus+	time_stop	NA (NA, NA)	27 (17, 35)	19 (12, 31)	26 (17, 34)	26 (16, 35)	24 (17, 35)
TEfus+	post_p	NA (NA, NA)	0.03 (0, 0.25)	1 (0.96, 1)	0.03 (0, 0.19)	0.03 (0, 0.21)	0.03 (0, 0.25)
TEfus+	rate	0.077 (0.066, 0.089)	0.115 (0.094, 0.145)	0.038 (0.028, 0.05)	0.114 (0.097, 0.143)	0.116 (0.096, 0.142)	0.116 (0.094, 0.142)
PI3K+	graduation	0	0	173	0	0	0
PI3K+	futility	0	125	0	113	122	172
PI3K+	max_n	0	0	0	0	0	0
PI3K+	n	132 (114, 151)	52 (26, 85)	28 (9, 70)	54 (30, 82)	53 (29, 84)	54 (28, 86)
PI3K+	n_unique	123 (106, 141)	47 (24, 78)	26 (8, 65)	50 (28, 78)	48 (26, 78)	50 (26, 80)
PI3K+	time_trial	36 (36, 36)	36 (22, 36)	36 (17, 36)	36 (24, 36)	36 (23, 36)	36 (15, 36)
PI3K+	time_stop	NA (NA, NA)	25 (16, 35)	20 (14, 31)	26 (17, 34)	25 (17, 35)	19 (10, 33)
PI3K+	post_p	NA (NA, NA)	0.03 (0, 0.23)	1 (0.92, 1)	0.03 (0, 0.2)	0.03 (0, 0.2)	0.03 (0, 0.19)
PI3K+	rate	0.077 (0.066, 0.088)	0.115 (0.095, 0.147)	0.038 (0.026, 0.052)	0.115 (0.094, 0.143)	0.116 (0.096, 0.144)	0.115 (0.095, 0.14)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4	TC5
—–	graduation	0	7	423	2	6	3
—–	futility	0	264	0	233	218	249
—–	max_n	0	39	71	78	65	61
—–	n	145 (123, 165)	26 (15, 85)	23 (12, 106)	31 (10, 98)	29 (8, 97)	28 (8, 93)
—–	n_unique	138 (117, 157)	25 (15, 81)	22 (11, 102)	29 (9, 94)	26 (7, 90)	26 (7, 90)
—–	post_p	NA (NA, NA)	0.05 (0, 0.23)	1 (0.92, 1)	0.06 (0, 0.28)	0.06 (0, 0.34)	0.06 (0, 0.29)
—–	rate	0.076 (0.067, 0.088)	0.118 (0.095, 0.156)	0.039 (0.028, 0.052)	0.116 (0.094, 0.162)	0.119 (0.092, 0.172)	0.119 (0.094, 0.193)
—-+	graduation	0	7	431	2	6	3
—-+	futility	0	299	0	265	252	297
—-+	max_n	0	37	68	76	64	59
—-+	n	32 (24, 41)	9 (3, 26)	4 (1, 15)	9 (3, 26)	10 (3, 26)	10 (5, 27)
—-+	n_unique	30 (22, 39)	8 (3, 24)	3 (0, 13)	8 (3, 24)	9 (3, 25)	9 (4, 25)
—-+	post_p	NA (NA, NA)	0.23 (0.08, 0.55)	0.86 (0.49, 0.99)	0.23 (0.07, 0.52)	0.25 (0.08, 0.58)	0.23 (0.07, 0.56)
—-+	rate	0.076 (0.058, 0.101)	0.127 (0.082, 0.248)	0.038 (0.014, 0.089)	0.125 (0.084, 0.268)	0.123 (0.082, 0.296)	0.12 (0.082, 0.227)
—+-	graduation	0	8	425	2	6	4
—+-	futility	0	278	0	245	229	259
—+-	max_n	0	38	71	77	64	60
—+-	n	5 (2, 9)	2 (0, 6)	1 (0, 4)	2 (0, 6)	2 (0, 6)	2 (0, 6)
—+-	n_unique	5 (2, 9)	2 (0, 5)	1 (0, 3)	2 (0, 5)	2 (0, 5)	2 (0, 5)
—+-	post_p	NA (NA, NA)	0.43 (0.28, 0.66)	0.65 (0.43, 0.87)	0.43 (0.26, 0.67)	0.43 (0.25, 0.66)	0.42 (0.27, 0.66)
—+-	rate	0.081 (0.035, 0.186)	0.129 (0.06, 0.396)	0.047 (0, 0.145)	0.129 (0.054, 0.358)	0.13 (0.054, 0.491)	0.135 (0.052, 0.462)
—++	graduation	0	8	432	2	6	4
—++	futility	0	304	0	272	258	302
—++	max_n	0	36	68	75	63	58
—++	n	14 (9, 20)	5 (1, 13)	2 (0, 6)	5 (1, 13)	5 (1, 13)	5 (2, 13)
—++	n_unique	13 (8, 19)	4 (1, 12)	2 (0, 6)	5 (1, 12)	4 (1, 12)	5 (2, 12)
—++	post_p	NA (NA, NA)	0.34 (0.16, 0.64)	0.76 (0.45, 0.94)	0.35 (0.16, 0.63)	0.35 (0.15, 0.68)	0.32 (0.15, 0.59)
—++	rate	0.078 (0.046, 0.119)	0.13 (0.075, 0.357)	0.042 (0, 0.124)	0.135 (0.072, 0.384)	0.127 (0.07, 0.342)	0.132 (0.077, 0.32)
–+–	graduation	0	3	363	0	2	1
–+–	futility	0	202	0	161	170	183
–+–	max_n	0	0	0	0	0	0
–+–	n	29 (21, 37)	10 (4, 25)	8 (2, 28)	9 (4, 22)	9 (4, 25)	8 (3, 22)
–+–	n_unique	27 (19, 35)	9 (4, 23)	7 (2, 26)	8 (3, 20)	8 (3, 23)	7 (3, 21)
–+–	post_p	NA (NA, NA)	0.23 (0.08, 0.62)	0.92 (0.62, 1)	0.26 (0.09, 0.59)	0.25 (0.08, 0.58)	0.24 (0.08, 0.57)
–+–	rate	0.078 (0.055, 0.109)	0.12 (0.079, 0.223)	0.039 (0.018, 0.071)	0.123 (0.079, 0.254)	0.123 (0.08, 0.243)	0.127 (0.08, 0.249)
–+-+	graduation	0	3	408	0	2	1
–+-+	futility	0	247	0	206	219	255
–+-+	max_n	0	0	0	0	0	0
–+-+	n	28 (20, 36)	8 (3, 23)	6 (1, 21)	9 (4, 24)	8 (4, 23)	9 (4, 22)
–+-+	n_unique	26 (18, 34)	7 (3, 22)	5 (1, 20)	8 (3, 22)	8 (3, 22)	8 (3, 20)
–+-+	post_p	NA (NA, NA)	0.23 (0.09, 0.58)	0.88 (0.47, 0.99)	0.26 (0.09, 0.59)	0.26 (0.09, 0.58)	0.25 (0.09, 0.61)
–+-+	rate	0.076 (0.057, 0.105)	0.129 (0.081, 0.302)	0.04 (0.018, 0.094)	0.121 (0.077, 0.266)	0.126 (0.08, 0.258)	0.123 (0.08, 0.23)
–++-	graduation	0	4	389	0	2	2
–++-	futility	0	229	0	186	194	220
–++-	max_n	0	0	0	0	0	0
–++-	n	8 (4, 12)	3 (1, 7)	3 (0, 7)	3 (1, 7)	3 (1, 6)	3 (1, 7)
–++-	n_unique	7 (4, 11)	3 (1, 6)	2 (0, 7)	3 (1, 6)	3 (1, 6)	3 (1, 6)
–++-	post_p	NA (NA, NA)	0.38 (0.22, 0.67)	0.72 (0.4, 0.93)	0.4 (0.21, 0.64)	0.41 (0.22, 0.65)	0.39 (0.23, 0.64)
–++-	rate	0.077 (0.038, 0.145)	0.13 (0.055, 0.384)	0.042 (0.012, 0.131)	0.134 (0.057, 0.453)	0.13 (0.06, 0.38)	0.13 (0.058, 0.421)
–+++	graduation	0	4	421	0	2	2
–+++	futility	0	263	0	223	233	276
–+++	max_n	0	0	0	0	0	0
–+++	n	21 (15, 28)	7 (2, 17)	5 (1, 16)	7 (2, 18)	6 (2, 16)	7 (3, 17)
–+++	n_unique	20 (13, 27)	6 (2, 16)	4 (1, 15)	6 (2, 17)	6 (2, 15)	6 (3, 16)
–+++	post_p	NA (NA, NA)	0.29 (0.11, 0.61)	0.87 (0.47, 0.99)	0.31 (0.12, 0.64)	0.3 (0.12, 0.57)	0.29 (0.13, 0.63)
–+++	rate	0.077 (0.055, 0.112)	0.129 (0.076, 0.293)	0.039 (0.017, 0.095)	0.128 (0.074, 0.304)	0.128 (0.077, 0.317)	0.122 (0.076, 0.243)
-+—	graduation	0	8	429	2	7	4
-+—	futility	0	286	0	271	270	280
-+—	max_n	0	36	66	76	62	57
-+—	n	28 (19, 36)	8 (1, 23)	3 (0, 15)	10 (4, 21)	10 (5, 24)	9 (3, 23)
-+—	n_unique	26 (17, 33)	7 (1, 21)	3 (0, 14)	9 (4, 20)	9 (4, 23)	8 (3, 21)
-+—	post_p	NA (NA, NA)	0.28 (0.11, 0.55)	0.84 (0.52, 0.99)	0.26 (0.08, 0.56)	0.24 (0.08, 0.57)	0.26 (0.08, 0.59)
-+—	rate	0.076 (0.056, 0.105)	0.125 (0.084, 0.286)	0.041 (0.015, 0.085)	0.12 (0.082, 0.23)	0.12 (0.081, 0.222)	0.125 (0.081, 0.268)
-+–+	graduation	0	8	437	2	7	3
-+–+	futility	0	315	0	296	298	317
-+–+	max_n	0	34	63	74	61	57
-+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	post_p	NA (NA, NA)	0.48 (0.48, 0.51)	0.6 (0.6, 0.6)	0.53 (0.53, 0.53)	0.45 (0.43, 0.47)	0.51 (0.45, 0.56)
-+–+	rate	0.211 (0, 1.259)	0.15 (0, 10.787)	0 (0, 0.048)	0.132 (0, 3.66)	0.171 (0, 0.36)	0.065 (0, 0.471)
-+-+-	graduation	0	9	430	2	7	5
-+-+-	futility	0	298	0	281	277	287
-+-+-	max_n	0	35	66	75	61	56
-+-+-	n	13 (8, 18)	4 (0, 12)	1 (0, 5)	6 (2, 12)	5 (2, 12)	5 (1, 12)
-+-+-	n_unique	12 (7, 17)	4 (0, 11)	1 (0, 5)	5 (2, 11)	5 (2, 12)	4 (1, 11)
-+-+-	post_p	NA (NA, NA)	0.37 (0.19, 0.69)	0.75 (0.39, 0.93)	0.33 (0.14, 0.62)	0.36 (0.17, 0.66)	0.36 (0.19, 0.66)
-+-+-	rate	0.079 (0.047, 0.121)	0.125 (0.059, 0.318)	0.04 (0, 0.157)	0.132 (0.075, 0.322)	0.123 (0.068, 0.286)	0.129 (0.07, 0.383)
-+-++	graduation	0	9	437	2	7	4
-+-++	futility	0	320	0	302	301	320
-+-++	max_n	0	33	63	73	60	56
-+-++	n	5 (2, 9)	2 (0, 6)	0 (0, 3)	2 (1, 6)	3 (1, 6)	2 (0, 5)
-+-++	n_unique	5 (2, 9)	1 (0, 5)	0 (0, 2)	2 (0, 6)	2 (0, 6)	2 (0, 5)
-+-++	post_p	NA (NA, NA)	0.43 (0.27, 0.68)	0.63 (0.42, 0.82)	0.42 (0.25, 0.64)	0.42 (0.26, 0.64)	0.43 (0.28, 0.66)
-+-++	rate	0.076 (0.035, 0.167)	0.127 (0.05, 0.433)	0.048 (0, 0.185)	0.141 (0.058, 0.484)	0.131 (0.056, 0.466)	0.129 (0.05, 0.438)
-++–	graduation	0	5	377	0	4	2
-++–	futility	0	234	0	219	228	215
-++–	max_n	0	0	0	0	0	0
-++–	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	post_p	NA (NA, NA)	0.5 (0.5, 0.5)	0.54 (0.54, 0.54)	0.53 (0.51, 0.55)	0.56 (0.56, 0.56)	NA (NA, NA)
-++–	rate	0.234 (0, 0.66)	0.174 (0, 0.992)	0.041 (0, 0.155)	0.167 (0, 1.294)	0.148 (0, 0.896)	0.237 (0, 1.533)
-++-+	graduation	0	5	420	0	4	1
-++-+	futility	0	267	0	255	266	273
-++-+	max_n	0	0	0	0	0	0
-++-+	n	3 (1, 6)	1 (0, 4)	0 (0, 3)	2 (0, 4)	2 (0, 4)	1 (0, 4)
-++-+	n_unique	3 (1, 5)	1 (0, 3)	0 (0, 2)	2 (0, 4)	1 (0, 4)	1 (0, 3)
-++-+	post_p	NA (NA, NA)	0.44 (0.31, 0.65)	0.61 (0.44, 0.8)	0.45 (0.32, 0.64)	0.45 (0.3, 0.65)	0.45 (0.29, 0.63)
-++-+	rate	0.085 (0, 0.25)	0.152 (0.045, 0.577)	0.033 (0, 0.191)	0.144 (0.045, 0.567)	0.141 (0.051, 0.496)	0.142 (0.041, 0.791)
-+++-	graduation	0	6	401	0	4	3
-+++-	futility	0	256	0	237	245	246
-+++-	max_n	0	0	0	0	0	0
-+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	post_p	NA (NA, NA)	0.47 (0.42, 0.51)	NA (NA, NA)	0.46 (0.46, 0.46)	0.56 (0.56, 0.56)	0.49 (0.49, 0.49)
-+++-	rate	0.116 (0, 1.344)	0.203 (0, 1.352)	0 (0, 0.235)	0.119 (0, 3.545)	0.115 (0.04, 1.431)	0.122 (0, 0.385)
-++++	graduation	0	6	432	0	4	2
-++++	futility	0	283	0	266	277	294
-++++	max_n	0	0	0	0	0	0
-++++	n	3 (1, 6)	1 (0, 4)	0 (0, 3)	2 (0, 4)	2 (0, 4)	1 (0, 4)
-++++	n_unique	3 (1, 6)	1 (0, 4)	0 (0, 2)	2 (0, 4)	2 (0, 4)	1 (0, 3)
-++++	post_p	NA (NA, NA)	0.44 (0.31, 0.63)	0.61 (0.44, 0.79)	0.44 (0.31, 0.67)	0.43 (0.28, 0.6)	0.45 (0.31, 0.65)
-++++	rate	0.077 (0, 0.224)	0.135 (0.035, 0.487)	0.039 (0, 0.171)	0.129 (0.045, 0.46)	0.138 (0.05, 0.57)	0.13 (0.038, 0.457)
+—-	graduation	0	3	225	0	2	1
+—-	futility	0	37	0	17	23	26
+—-	max_n	0	0	0	0	0	0
+—-	n	5 (2, 8)	2 (1, 6)	3 (0, 6)	2 (0, 5)	2 (1, 5)	2 (1, 5)
+—-	n_unique	4 (2, 8)	2 (0, 5)	2 (0, 6)	2 (0, 4)	2 (1, 4)	2 (0, 5)
+—-	post_p	NA (NA, NA)	0.42 (0.26, 0.63)	0.67 (0.43, 0.89)	0.41 (0.26, 0.62)	0.42 (0.26, 0.64)	0.45 (0.29, 0.65)
+—-	rate	0.082 (0.034, 0.187)	0.131 (0.047, 0.412)	0.045 (0, 0.131)	0.131 (0.041, 0.452)	0.125 (0.048, 0.442)	0.112 (0.046, 0.391)
+—+	graduation	0	3	336	0	2	1
+—+	futility	0	146	0	119	130	177
+—+	max_n	0	0	0	0	0	0
+—+	n	2 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	n_unique	2 (0, 4)	1 (0, 3)	1 (0, 2)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	post_p	NA (NA, NA)	0.46 (0.33, 0.62)	0.59 (0.43, 0.78)	0.46 (0.35, 0.61)	0.45 (0.34, 0.63)	0.46 (0.35, 0.6)
+—+	rate	0.087 (0, 0.292)	0.139 (0.021, 0.516)	0.043 (0, 0.165)	0.129 (0.029, 0.627)	0.134 (0.029, 0.629)	0.138 (0.037, 0.522)
+–+-	graduation	0	4	290	0	2	2
+–+-	futility	0	99	0	78	75	101
+–+-	max_n	0	0	0	0	0	0
+–+-	n	8 (4, 12)	3 (1, 7)	4 (1, 9)	3 (1, 8)	3 (1, 7)	3 (1, 6)
+–+-	n_unique	7 (4, 12)	3 (1, 7)	3 (1, 9)	3 (1, 7)	3 (1, 6)	3 (1, 6)
+–+-	post_p	NA (NA, NA)	0.38 (0.2, 0.68)	0.76 (0.46, 0.96)	0.39 (0.25, 0.64)	0.38 (0.21, 0.64)	0.39 (0.21, 0.65)
+–+-	rate	0.082 (0.044, 0.149)	0.144 (0.053, 0.385)	0.041 (0.013, 0.108)	0.128 (0.063, 0.488)	0.138 (0.062, 0.446)	0.129 (0.055, 0.413)
+–++	graduation	0	4	368	0	2	2
+–++	futility	0	172	0	150	153	210
+–++	max_n	0	0	0	0	0	0
+–++	n	4 (1, 7)	2 (0, 5)	1 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 5)
+–++	n_unique	3 (1, 6)	2 (0, 4)	1 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 4)
+–++	post_p	NA (NA, NA)	0.45 (0.28, 0.64)	0.65 (0.44, 0.85)	0.45 (0.28, 0.66)	0.42 (0.28, 0.66)	0.42 (0.28, 0.6)
+–++	rate	0.081 (0.027, 0.235)	0.127 (0.048, 0.425)	0.04 (0, 0.137)	0.126 (0.038, 0.403)	0.131 (0.043, 0.511)	0.144 (0.053, 0.565)
+-+–	graduation	0	3	363	0	2	1
+-+–	futility	0	202	0	161	170	183
+-+–	max_n	0	0	0	0	0	0
+-+–	n	1 (0, 3)	1 (0, 2)	0 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	n_unique	1 (0, 3)	1 (0, 2)	0 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	post_p	NA (NA, NA)	0.47 (0.36, 0.62)	0.55 (0.42, 0.69)	0.47 (0.39, 0.6)	0.46 (0.37, 0.61)	0.46 (0.36, 0.6)
+-+–	rate	0.086 (0, 0.354)	0.143 (0, 0.72)	0.043 (0, 0.279)	0.134 (0, 0.505)	0.141 (0, 0.67)	0.135 (0, 0.8)
+-+-+	graduation	0	3	408	0	2	1
+-+-+	futility	0	247	0	206	219	255
+-+-+	max_n	0	0	0	0	0	0
+-+-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	post_p	NA (NA, NA)	0.47 (0.43, 0.5)	0.55 (0.55, 0.56)	0.52 (0.51, 0.52)	0.48 (0.43, 0.54)	0.56 (0.56, 0.56)
+-+-+	rate	0.104 (0, 1.417)	0.093 (0, 0.546)	0.039 (0, 0.119)	0.105 (0, 0.662)	0.109 (0, 0.782)	0.128 (0.03, 0.759)
+-++-	graduation	0	4	389	0	2	2
+-++-	futility	0	229	0	186	194	220
+-++-	max_n	0	0	0	0	0	0
+-++-	n	24 (17, 31)	6 (2, 18)	8 (3, 22)	7 (3, 18)	7 (3, 18)	6 (2, 18)
+-++-	n_unique	22 (15, 29)	6 (2, 16)	8 (2, 20)	7 (3, 17)	6 (2, 17)	6 (2, 17)
+-++-	post_p	NA (NA, NA)	0.27 (0.1, 0.55)	0.92 (0.6, 1)	0.28 (0.1, 0.59)	0.29 (0.1, 0.58)	0.28 (0.12, 0.56)
+-++-	rate	0.079 (0.054, 0.108)	0.133 (0.078, 0.33)	0.039 (0.02, 0.071)	0.128 (0.076, 0.275)	0.122 (0.076, 0.311)	0.134 (0.081, 0.316)
+-+++	graduation	0	4	421	0	2	2
+-+++	futility	0	263	0	223	233	276
+-+++	max_n	0	0	0	0	0	0
+-+++	n	18 (12, 24)	6 (2, 15)	4 (1, 13)	6 (2, 15)	6 (2, 15)	5 (2, 16)
+-+++	n_unique	16 (11, 22)	5 (1, 14)	4 (1, 12)	5 (2, 14)	5 (2, 14)	5 (2, 15)
+-+++	post_p	NA (NA, NA)	0.33 (0.15, 0.61)	0.84 (0.48, 0.98)	0.29 (0.13, 0.61)	0.3 (0.13, 0.67)	0.3 (0.13, 0.64)
+-+++	rate	0.078 (0.05, 0.113)	0.127 (0.074, 0.302)	0.039 (0.015, 0.095)	0.131 (0.079, 0.321)	0.128 (0.077, 0.323)	0.127 (0.078, 0.281)
++—	graduation	0	5	257	0	4	2
++—	futility	0	88	0	108	121	86
++—	max_n	0	0	0	0	0	0
++—	n	8 (4, 13)	3 (1, 7)	3 (0, 8)	4 (2, 8)	4 (2, 8)	4 (1, 8)
++—	n_unique	7 (4, 12)	3 (1, 6)	3 (0, 8)	4 (2, 8)	4 (2, 7)	3 (1, 7)
++—	post_p	NA (NA, NA)	0.4 (0.21, 0.69)	0.75 (0.44, 0.94)	0.37 (0.2, 0.67)	0.37 (0.18, 0.65)	0.38 (0.21, 0.65)
++—	rate	0.077 (0.04, 0.147)	0.13 (0.06, 0.383)	0.04 (0, 0.125)	0.122 (0.061, 0.297)	0.125 (0.065, 0.372)	0.13 (0.065, 0.373)
++–+	graduation	0	5	358	0	4	1
++–+	futility	0	175	0	186	200	210
++–+	max_n	0	0	0	0	0	0
++–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	post_p	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	0.48 (0.48, 0.48)	0.5 (0.46, 0.53)	NA (NA, NA)
++–+	rate	0.121 (0, 1.239)	0.089 (0, 0.84)	0.056 (0, 0.24)	0.109 (0.013, 0.293)	0.238 (0, 0.826)	0.118 (0, 0.37)
++-+-	graduation	0	6	313	0	4	3
++-+-	futility	0	139	0	155	155	148
++-+-	max_n	0	0	0	0	0	0
++-+-	n	1 (0, 3)	0 (0, 2)	0 (0, 1)	1 (0, 2)	1 (0, 2)	0 (0, 2)
++-+-	n_unique	1 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 2)	1 (0, 2)	0 (0, 2)
++-+-	post_p	NA (NA, NA)	0.47 (0.4, 0.57)	0.56 (0.46, 0.63)	0.47 (0.4, 0.59)	0.46 (0.38, 0.59)	0.47 (0.4, 0.57)
++-+-	rate	0.079 (0, 0.585)	0.154 (0, 0.651)	0.025 (0, 0.158)	0.127 (0, 0.739)	0.139 (0.031, 0.784)	0.129 (0, 0.838)
++-++	graduation	0	6	385	0	4	2
++-++	futility	0	201	0	208	216	241
++-++	max_n	0	0	0	0	0	0
++-++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	post_p	NA (NA, NA)	NA (NA, NA)	0.49 (0.49, 0.49)	0.49 (0.43, 0.55)	0.5 (0.46, 0.55)	0.47 (0.47, 0.47)
++-++	rate	0.146 (0, 1.672)	0.099 (0, 0.204)	0.057 (0, 0.407)	0.187 (0, 2.527)	0.379 (0.052, 1.228)	0.035 (0, 0.188)
+++–	graduation	0	5	377	0	4	2
+++–	futility	0	234	0	219	228	215
+++–	max_n	0	0	0	0	0	0
+++–	n	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	n_unique	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	post_p	NA (NA, NA)	0.52 (0.44, 0.57)	0.52 (0.43, 0.6)	0.46 (0.43, 0.55)	0.48 (0.42, 0.56)	0.49 (0.44, 0.57)
+++–	rate	0.064 (0, 0.664)	0.149 (0, 0.578)	0.048 (0, 0.399)	0.186 (0, 0.973)	0.186 (0, 0.715)	0.109 (0, 0.359)
+++-+	graduation	0	5	420	0	4	1
+++-+	futility	0	267	0	255	266	273
+++-+	max_n	0	0	0	0	0	0
+++-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	post_p	NA (NA, NA)	0.52 (0.52, 0.52)	0.47 (0.47, 0.47)	0.44 (0.41, 0.47)	0.55 (0.47, 0.57)	0.48 (0.47, 0.5)
+++-+	rate	0.075 (0, 0.529)	0.09 (0, 0.606)	0.085 (0.012, 0.308)	0.182 (0.041, 0.943)	0.121 (0.029, 1.358)	0.085 (0, 1.108)
++++-	graduation	0	6	401	0	4	3
++++-	futility	0	256	0	237	245	246
++++-	max_n	0	0	0	0	0	0
++++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	post_p	NA (NA, NA)	0.48 (0.46, 0.49)	0.54 (0.54, 0.54)	0.47 (0.47, 0.47)	0.54 (0.54, 0.54)	NA (NA, NA)
++++-	rate	0.063 (0, 0.498)	0.117 (0, 2.046)	0.019 (0, 0.599)	0.128 (0, 0.803)	0.061 (0, 0.491)	0.121 (0, 0.832)
+++++	graduation	0	6	432	0	4	2
+++++	futility	0	283	0	266	277	294
+++++	max_n	0	0	0	0	0	0
+++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	post_p	NA (NA, NA)	0.48 (0.43, 0.5)	0.52 (0.45, 0.59)	0.52 (0.47, 0.57)	0.47 (0.42, 0.48)	0.55 (0.46, 0.57)
+++++	rate	0.08 (0, 0.373)	0.176 (0, 0.55)	0.061 (0, 0.888)	0.169 (0, 1.082)	0.185 (0, 0.836)	0.057 (0, 0.796)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	3	225		2	1
all	time_stop	5 (5, 5)	10 (5, 28)		7 (6, 8)	5 (5, 5)
all	n_trt	30 (28, 33)	55 (28, 144)		27 (25, 29)	33 (33, 33)
all	n_control	52 (43, 54)	88 (49, 295)		62 (57, 68)	46 (46, 46)
all	post_p	0.91 (0.88, 0.94)	1 (0.92, 1)		0.9 (0.9, 0.91)	0.86 (0.86, 0.86)
all	order	1 (1, 1)	1 (1, 4)		1.5 (1.1, 1.9)	1 (1, 1)
AR- & TP53-	count	4	325	2	4	2
AR- & TP53-	time_stop	6 (5, 7)	11 (8, 25)	10 (10, 11)	14 (10, 15)	14 (12, 16)
AR- & TP53-	n_trt	30 (26, 33)	35 (25, 115)	28 (26, 30)	36 (26, 52)	29 (27, 31)
AR- & TP53-	n_control	42 (29, 54)	60 (38, 150)	58 (56, 60)	72 (52, 87)	82 (69, 94)
AR- & TP53-	post_p	0.92 (0.89, 0.96)	0.98 (0.91, 1)	0.96 (0.94, 0.99)	0.96 (0.93, 0.99)	0.93 (0.92, 0.95)
AR- & TP53-	order	1 (1, 1)	1 (1, 3)	2 (1.2, 2.8)	1.5 (1, 2)	2 (2, 2)
HRD+	count	2	40		2	1
HRD+	time_stop	20 (20, 21)	28 (21, 35)		20 (15, 26)	20 (20, 20)
HRD+	n_trt	28 (26, 29)	26 (25, 37)		25 (25, 25)	26 (26, 26)
HRD+	n_control	33 (33, 33)	45 (29, 62)		30 (17, 43)	25 (25, 25)
HRD+	post_p	0.89 (0.87, 0.92)	0.99 (0.95, 1)		0.9 (0.86, 0.94)	0.93 (0.93, 0.93)
HRD+	order	4 (3.2, 4.8)	2 (1, 5)		4 (2.4, 5.6)	2 (2, 2)
TP53+	count		219
TP53+	time_stop		18 (12, 29)
TP53+	n_trt		37 (26, 70)
TP53+	n_control		52 (33, 98)
TP53+	post_p		1 (0.96, 1)
TP53+	order		2 (1, 4)
TEfus+	count	1	146			1
TEfus+	time_stop	21 (21, 21)	19 (12, 31)			12 (12, 12)
TEfus+	n_trt	28 (28, 28)	34 (25, 58)			26 (26, 26)
TEfus+	n_control	59 (59, 59)	53 (31, 108)			31 (31, 31)
TEfus+	post_p	0.98 (0.98, 0.98)	1 (0.98, 1)			0.87 (0.87, 0.87)
TEfus+	order	1 (1, 1)	3 (1, 5)			1 (1, 1)
PI3K+	count		173
PI3K+	time_stop		20 (14, 31)
PI3K+	n_trt		31 (25, 57)
PI3K+	n_control		59 (36, 107)
PI3K+	post_p		1 (0.97, 1)
PI3K+	order		2 (1, 4)

Futility:

signature	var	TC1	TC3	TC4	TC5
all	count	37	17	23	26
all	time_stop	16 (3, 31)	28 (11, 35)	26 (9, 35)	24 (10, 34)
all	n_trt	72 (27, 112)	85 (47, 119)	78 (33, 129)	70 (39, 124)
all	n_control	152 (34, 331)	290 (78, 412)	269 (87, 405)	250 (82, 387)
all	post_p	0 (0, 0.18)	0 (0, 0.06)	0 (0, 0.01)	0 (0, 0.02)
all	order	3 (1, 7)	5 (1, 9)	4 (1, 8)	6 (1, 8.5)
AR- & TP53-	count	250	232	213	245
AR- & TP53-	time_stop	18 (7, 32)	22 (12, 33)	21 (12, 33)	23 (13, 32)
AR- & TP53-	n_trt	45 (26, 93)	50 (27, 102)	43 (26, 111)	43 (26, 112)
AR- & TP53-	n_control	104 (37, 213)	134 (65, 219)	125 (64, 219)	140 (68, 219)
AR- & TP53-	post_p	0.03 (0, 0.19)	0.01 (0, 0.12)	0.03 (0, 0.11)	0.02 (0, 0.13)
AR- & TP53-	order	2 (1, 6)	3 (1, 6)	3 (1, 6)	3 (1, 6)
HRD+	count	53	96	102	62
HRD+	time_stop	32 (24, 35)	27 (20, 35)	30 (22, 34)	31 (25, 36)
HRD+	n_trt	28 (25, 40)	28 (25, 38)	29 (25, 40)	28 (25, 40)
HRD+	n_control	54 (36, 66)	41 (26, 62)	47 (31, 64)	50 (35, 65)
HRD+	post_p	0.05 (0.01, 0.22)	0.07 (0.01, 0.19)	0.06 (0.01, 0.2)	0.07 (0.01, 0.19)
HRD+	order	6 (3, 8)	4 (1, 8)	5 (2, 8.9)	6 (3, 9)
TP53+	count	182	156	165	177
TP53+	time_stop	24 (15, 34)	24 (16, 32)	25 (16, 34)	23 (13, 34)
TP53+	n_trt	38 (25, 62)	34 (26, 53)	37 (26, 63)	33 (25, 59)
TP53+	n_control	78 (44, 124)	78 (47, 117)	84 (46, 124)	76 (34, 129)
TP53+	post_p	0.03 (0, 0.11)	0.03 (0, 0.12)	0.03 (0, 0.1)	0.03 (0, 0.12)
TP53+	order	3 (1, 7)	3 (1, 6.5)	3 (1, 7.6)	3 (1, 7)
TEfus+	count	78	72	69	92
TEfus+	time_stop	27 (17, 35)	26 (17, 34)	26 (16, 35)	24 (17, 35)
TEfus+	n_trt	36 (26, 49)	33 (25, 50)	34 (26, 53)	34 (25, 53)
TEfus+	n_control	87 (46, 122)	84 (49, 121)	80 (44, 125)	75 (43, 124)
TEfus+	post_p	0.01 (0, 0.06)	0.01 (0, 0.1)	0.02 (0, 0.07)	0.01 (0, 0.11)
TEfus+	order	5 (2, 8)	5 (2, 8)	5 (2, 8)	5 (2, 8.9)
PI3K+	count	125	113	122	172
PI3K+	time_stop	25 (16, 35)	26 (17, 34)	25 (17, 35)	19 (10, 33)
PI3K+	n_trt	36 (26, 66)	36 (26, 53)	36 (26, 61)	34 (26, 58)
PI3K+	n_control	79 (48, 121)	86 (48, 127)	80 (51, 125)	57 (23, 118)
PI3K+	post_p	0.02 (0, 0.09)	0.02 (0, 0.09)	0.02 (0, 0.07)	0.03 (0, 0.18)
PI3K+	order	5 (2, 8)	4 (2, 8)	5 (2, 8)	3 (1, 6.9)

By subgroup combinations

Graduation:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC1	time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
all	TC1	n	17 (13, 19)	2 (0, 3)	0 (0, 2)	2 (0, 2)	3 (1, 4)	2 (0, 3)	0 (0, 0)	1 (1, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	1 (0, 1)	0 (0, 0)	0 (0, 2)	0 (0, 2)	0 (0, 0)	0 (0, 0)	2 (0, 3)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.7 (0.69, 0.75)	0.55 (0.55, 0.55)	NA (NA, NA)	0.54 (0.52, 0.57)	0.54 (0.54, 0.55)	0.54 (0.53, 0.55)	NA (NA, NA)	0.52 (0.51, 0.53)	0.53 (0.53, 0.53)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	0.57 (0.57, 0.57)	NA (NA, NA)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.58 (0.58, 0.58)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.034 (0.032, 0.039)	0.073 (0.015, 0.131)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225	225
all	TC2	time	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)	10 (5, 28)
all	TC2	n	18 (9, 56)	3 (0, 9)	1 (0, 2)	1 (0, 4)	4 (1, 12)	3 (1, 11)	2 (0, 5)	3 (0, 9)	2 (0, 10)	0 (0, 0)	1 (0, 4)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)	1 (0, 4)	0 (0, 2)	2 (0, 5)	1 (0, 3)	0 (0, 1)	0 (0, 0)	5 (2, 14)	3 (1, 8)	1 (0, 5)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.9 (0.61, 1)	0.62 (0.52, 0.92)	0.55 (0.52, 0.68)	0.57 (0.52, 0.83)	0.64 (0.52, 0.94)	0.59 (0.52, 0.91)	0.57 (0.52, 0.78)	0.61 (0.52, 0.93)	0.62 (0.53, 0.91)	NA (NA, NA)	0.61 (0.52, 0.82)	0.57 (0.52, 0.73)	0.52 (0.52, 0.52)	0.58 (0.51, 0.68)	NA (NA, NA)	0.58 (0.51, 0.75)	0.55 (0.51, 0.73)	0.55 (0.51, 0.6)	0.57 (0.51, 0.8)	0.58 (0.52, 0.75)	0.54 (0.51, 0.6)	0.53 (0.53, 0.53)	0.61 (0.52, 0.96)	0.61 (0.51, 0.88)	0.6 (0.52, 0.85)	NA (NA, NA)	0.54 (0.52, 0.64)	0.5 (0.5, 0.5)	0.54 (0.52, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.033 (0, 0.06)	0 (0, 0.066)	0 (0, 0.109)	0 (0, 0.071)	0 (0, 0.08)	0.016 (0, 0.076)	0 (0, 0.084)	0 (0, 0.077)	0 (0, 0.068)	0 (0, 0)	0 (0, 0.08)	0 (0, 0.08)	0 (0, 0.056)	0 (0, 0.063)	0.053 (0.011, 0.095)	0 (0, 0.073)	0 (0, 0.093)	0 (0, 0.098)	0 (0, 0.075)	0 (0, 0.138)	0 (0, 0.258)	0 (0, 0.034)	0.018 (0, 0.065)	0 (0, 0.077)	0 (0, 0.068)	0 (0, 0)	0 (0, 0.118)	0 (0, 0.08)	0 (0, 0.541)	0.203 (0.041, 0.366)	0 (0, 0)	0.342 (0.08, 1.138)
all	TC4	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC4	time	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)	7 (6, 8)
all	TC4	n	3 (1, 5)	2 (1, 3)	0 (0, 0)	2 (1, 3)	2 (1, 3)	0 (0, 1)	0 (0, 1)	0 (0, 1)	7 (7, 7)	0 (0, 0)	4 (3, 4)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	2 (1, 3)	1 (0, 2)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.63 (0.63, 0.63)	0.58 (0.54, 0.61)	NA (NA, NA)	0.56 (0.53, 0.59)	0.61 (0.59, 0.62)	0.57 (0.57, 0.57)	0.61 (0.61, 0.61)	0.51 (0.51, 0.51)	0.57 (0.52, 0.61)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	0.53 (0.51, 0.54)	0.51 (0.51, 0.51)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.09 (0.059, 0.121)	NA (NA, NA)	0.028 (0.006, 0.05)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0.03 (0.006, 0.054)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC5	time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
all	TC5	n	1 (1, 1)	9 (9, 9)	1 (1, 1)	1 (1, 1)	0 (0, 0)	7 (7, 7)	0 (0, 0)	3 (3, 3)	1 (1, 1)	0 (0, 0)	1 (1, 1)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	4 (4, 4)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.55 (0.55, 0.55)	0.56 (0.56, 0.56)	NA (NA, NA)	0.56 (0.56, 0.56)	NA (NA, NA)	0.62 (0.62, 0.62)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0 (0, 0)	0 (0, 0)	5.392 (5.392, 5.392)	0 (0, 0)	NA (NA, NA)	0.039 (0.039, 0.039)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	4	4	4	4					4	4	4	4
AR- & TP53-	TC1	time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)					6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
AR- & TP53-	TC1	n	22 (19, 27)	3 (1, 4)	2 (2, 2)	1 (0, 2)					2 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)
AR- & TP53-	TC1	post_p	0.81 (0.79, 0.89)	0.69 (0.59, 0.71)	0.52 (0.52, 0.52)	0.53 (0.51, 0.55)					0.57 (0.53, 0.59)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.044 (0.039, 0.051)	0 (0, 0.065)	0 (0, 0.158)	0 (0, 0)					0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
AR- & TP53-	TC2	count	325	325	325	325					325	325	325	325
AR- & TP53-	TC2	time	11 (8, 25)	11 (8, 25)	11 (8, 25)	11 (8, 25)					11 (8, 25)	11 (8, 25)	11 (8, 25)	11 (8, 25)
AR- & TP53-	TC2	n	24 (17, 80)	4 (1, 12)	1 (0, 3)	2 (0, 5)					3 (1, 11)	0 (0, 0)	2 (0, 5)	0 (0, 2)
AR- & TP53-	TC2	post_p	0.94 (0.77, 1)	0.64 (0.52, 0.9)	0.55 (0.51, 0.7)	0.58 (0.52, 0.8)					0.63 (0.52, 0.91)	0.61 (0.61, 0.61)	0.57 (0.52, 0.78)	0.55 (0.51, 0.71)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.035 (0.014, 0.054)	0 (0, 0.073)	0 (0, 0.118)	0 (0, 0.084)					0 (0, 0.083)	0 (0, 0)	0 (0, 0.081)	0 (0, 0.096)
AR- & TP53-	TC3	count	2	2	2	2					2	2	2	2
AR- & TP53-	TC3	time	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)					10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)
AR- & TP53-	TC3	n	16 (15, 17)	4 (2, 6)	0 (0, 1)	2 (1, 2)					2 (1, 2)	0 (0, 0)	3 (1, 5)	2 (0, 3)
AR- & TP53-	TC3	post_p	0.88 (0.86, 0.89)	0.73 (0.58, 0.88)	0.53 (0.53, 0.53)	0.6 (0.53, 0.67)					0.6 (0.54, 0.67)	NA (NA, NA)	0.51 (0.51, 0.51)	NA (NA, NA)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.021 (0.021, 0.021)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	NA (NA, NA)	0.052 (0.01, 0.093)	0.07 (0.07, 0.07)
AR- & TP53-	TC4	count	4	4	4	4					4	4	4	4
AR- & TP53-	TC4	time	14 (10, 15)	14 (10, 15)	14 (10, 15)	14 (10, 15)					14 (10, 15)	14 (10, 15)	14 (10, 15)	14 (10, 15)
AR- & TP53-	TC4	n	16 (14, 28)	4 (2, 5)	0 (0, 0)	3 (1, 6)					6 (5, 12)	0 (0, 0)	4 (1, 6)	0 (0, 2)
AR- & TP53-	TC4	post_p	0.84 (0.78, 0.92)	0.56 (0.5, 0.7)	NA (NA, NA)	0.62 (0.55, 0.7)					0.64 (0.55, 0.8)	NA (NA, NA)	0.58 (0.53, 0.67)	0.5 (0.5, 0.5)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.042 (0.033, 0.051)	0.032 (0, 0.094)	NA (NA, NA)	0.041 (0.008, 0.062)					0.064 (0.015, 0.08)	NA (NA, NA)	0.05 (0.038, 0.075)	0.09 (0.09, 0.09)
AR- & TP53-	TC5	count	2	2	2	2					2	2	2	2
AR- & TP53-	TC5	time	14 (12, 16)	14 (12, 16)	14 (12, 16)	14 (12, 16)					14 (12, 16)	14 (12, 16)	14 (12, 16)	14 (12, 16)
AR- & TP53-	TC5	n	13 (11, 15)	6 (4, 8)	0 (0, 1)	2 (1, 4)					6 (5, 6)	0 (0, 0)	2 (1, 2)	0 (0, 0)
AR- & TP53-	TC5	post_p	0.74 (0.73, 0.74)	0.63 (0.53, 0.73)	NA (NA, NA)	0.61 (0.6, 0.62)					0.73 (0.72, 0.73)	NA (NA, NA)	0.55 (0.52, 0.57)	NA (NA, NA)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.049 (0.039, 0.058)	0.096 (0.091, 0.101)	0 (0, 0)	0.016 (0.003, 0.029)					0.011 (0.002, 0.02)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
HRD+	TC1	count									2	2	2	2	2	2	2	2									2	2	2	2	2	2	2	2
HRD+	TC1	time									20 (20, 21)	20 (20, 21)	20 (20, 21)	20 (20, 21)	20 (20, 21)	20 (20, 21)	20 (20, 21)	20 (20, 21)									20 (20, 21)	20 (20, 21)	20 (20, 21)	20 (20, 21)	20 (20, 21)	20 (20, 21)	20 (20, 21)	20 (20, 21)
HRD+	TC1	n									14 (12, 16)	0 (0, 0)	4 (4, 5)	2 (0, 3)	0 (0, 0)	2 (1, 2)	0 (0, 0)	1 (0, 2)									4 (3, 5)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.73 (0.72, 0.74)	NA (NA, NA)	0.71 (0.6, 0.82)	0.53 (0.53, 0.53)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	0.59 (0.59, 0.59)									0.62 (0.58, 0.66)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.056 (0.053, 0.06)	NA (NA, NA)	0.03 (0.006, 0.054)	0.117 (0.117, 0.117)	NA (NA, NA)	1.114 (0.273, 1.956)	NA (NA, NA)	0.048 (0.048, 0.048)									0.075 (0.071, 0.079)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0.274 (0.274, 0.274)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									40	40	40	40	40	40	40	40									40	40	40	40	40	40	40	40
HRD+	TC2	time									28 (21, 35)	28 (21, 35)	28 (21, 35)	28 (21, 35)	28 (21, 35)	28 (21, 35)	28 (21, 35)	28 (21, 35)									28 (21, 35)	28 (21, 35)	28 (21, 35)	28 (21, 35)	28 (21, 35)	28 (21, 35)	28 (21, 35)	28 (21, 35)
HRD+	TC2	n									14 (8, 20)	0 (0, 0)	5 (1, 9)	2 (0, 4)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									5 (3, 9)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.93 (0.77, 0.99)	NA (NA, NA)	0.78 (0.57, 0.86)	0.65 (0.53, 0.86)	NA (NA, NA)	0.65 (0.52, 0.81)	NA (NA, NA)	0.59 (0.51, 0.82)									0.76 (0.58, 0.9)	NA (NA, NA)	0.56 (0.53, 0.6)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.034 (0.02, 0.053)	NA (NA, NA)	0.038 (0, 0.071)	0.014 (0, 0.106)	0.044 (0.044, 0.044)	0.016 (0, 0.063)	NA (NA, NA)	0 (0, 0.132)									0.034 (0, 0.061)	1.042 (0.367, 1.717)	0 (0, 0.129)	0 (0, 0)	1.004 (0.394, 1.613)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	count									2	2	2	2	2	2	2	2									2	2	2	2	2	2	2	2
HRD+	TC4	time									20 (15, 26)	20 (15, 26)	20 (15, 26)	20 (15, 26)	20 (15, 26)	20 (15, 26)	20 (15, 26)	20 (15, 26)									20 (15, 26)	20 (15, 26)	20 (15, 26)	20 (15, 26)	20 (15, 26)	20 (15, 26)	20 (15, 26)	20 (15, 26)
HRD+	TC4	n									11 (11, 11)	0 (0, 0)	5 (5, 5)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (1, 2)									7 (6, 8)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.77 (0.73, 0.81)	NA (NA, NA)	0.56 (0.52, 0.6)	0.59 (0.59, 0.59)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.54, 0.55)									0.77 (0.77, 0.77)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.051 (0.05, 0.051)	NA (NA, NA)	0.093 (0.067, 0.119)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.031 (0.006, 0.056)									0.063 (0.061, 0.065)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	count									1	1	1	1	1	1	1	1									1	1	1	1	1	1	1	1
HRD+	TC5	time									20 (20, 20)	20 (20, 20)	20 (20, 20)	20 (20, 20)	20 (20, 20)	20 (20, 20)	20 (20, 20)	20 (20, 20)									20 (20, 20)	20 (20, 20)	20 (20, 20)	20 (20, 20)	20 (20, 20)	20 (20, 20)	20 (20, 20)	20 (20, 20)
HRD+	TC5	n									14 (14, 14)	0 (0, 0)	2 (2, 2)	5 (5, 5)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									3 (3, 3)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)
HRD+	TC5	post_p									0.96 (0.96, 0.96)	NA (NA, NA)	0.52 (0.52, 0.52)	0.66 (0.66, 0.66)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)									0.68 (0.68, 0.68)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.062 (0.062, 0.062)	NA (NA, NA)	0.111 (0.111, 0.111)	0.084 (0.084, 0.084)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)									0.075 (0.075, 0.075)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
TP53+	TC2	count					219	219	219	219					219	219	219	219					219	219	219	219					219	219	219	219
TP53+	TC2	time					18 (12, 29)	18 (12, 29)	18 (12, 29)	18 (12, 29)					18 (12, 29)	18 (12, 29)	18 (12, 29)	18 (12, 29)					18 (12, 29)	18 (12, 29)	18 (12, 29)	18 (12, 29)					18 (12, 29)	18 (12, 29)	18 (12, 29)	18 (12, 29)
TP53+	TC2	n					8 (4, 18)	6 (3, 14)	3 (1, 6)	5 (2, 12)					0 (0, 0)	0 (0, 2)	0 (0, 0)	1 (0, 2)					0 (0, 2)	0 (0, 0)	9 (4, 16)	5 (2, 10)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.79 (0.56, 0.98)	0.75 (0.58, 0.95)	0.6 (0.51, 0.8)	0.75 (0.54, 0.92)					NA (NA, NA)	0.57 (0.52, 0.7)	NA (NA, NA)	0.57 (0.52, 0.74)					0.54 (0.51, 0.61)	0.56 (0.54, 0.58)	0.81 (0.64, 0.96)	0.73 (0.54, 0.91)					0.54 (0.53, 0.58)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.034 (0, 0.077)	0.034 (0, 0.071)	0.027 (0, 0.08)	0.034 (0, 0.076)					0.035 (0, 0.191)	0 (0, 0.108)	0.106 (0.021, 0.363)	0 (0, 0.08)					0 (0, 0.22)	0.039 (0, 0.131)	0.033 (0, 0.063)	0.03 (0, 0.077)					0 (0, 0.967)	0 (0, 0)	0 (0, 0)	0 (0, 0.829)
TEfus+	TC1	count			1	1			1	1			1	1			1	1			1	1			1	1			1	1			1	1
TEfus+	TC1	time			21 (21, 21)	21 (21, 21)			21 (21, 21)	21 (21, 21)			21 (21, 21)	21 (21, 21)			21 (21, 21)	21 (21, 21)			21 (21, 21)	21 (21, 21)			21 (21, 21)	21 (21, 21)			21 (21, 21)	21 (21, 21)			21 (21, 21)	21 (21, 21)
TEfus+	TC1	n			0 (0, 0)	3 (3, 3)			3 (3, 3)	4 (4, 4)			3 (3, 3)	1 (1, 1)			0 (0, 0)	0 (0, 0)			0 (0, 0)	2 (2, 2)			10 (10, 10)	2 (2, 2)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			NA (NA, NA)	0.65 (0.65, 0.65)			0.57 (0.57, 0.57)	0.92 (0.92, 0.92)			0.66 (0.66, 0.66)	0.52 (0.52, 0.52)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0.82 (0.82, 0.82)	0.52 (0.52, 0.52)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			NA (NA, NA)	0.06 (0.06, 0.06)			0.074 (0.074, 0.074)	0 (0, 0)			0.044 (0.044, 0.044)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	0.044 (0.044, 0.044)			0.052 (0.052, 0.052)	0.095 (0.095, 0.095)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			146	146			146	146			146	146			146	146			146	146			146	146			146	146			146	146
TEfus+	TC2	time			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)			19 (12, 31)	19 (12, 31)
TEfus+	TC2	n			1 (0, 3)	2 (0, 6)			3 (0, 6)	5 (2, 13)			2 (0, 5)	0 (0, 2)			0 (0, 0)	1 (0, 2)			4 (1, 8)	2 (0, 4)			9 (4, 17)	5 (2, 9)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.58 (0.52, 0.8)	0.67 (0.53, 0.88)			0.62 (0.52, 0.88)	0.77 (0.58, 0.95)			0.64 (0.52, 0.82)	0.59 (0.54, 0.71)			NA (NA, NA)	0.58 (0.52, 0.73)			0.67 (0.52, 0.9)	0.6 (0.52, 0.73)			0.83 (0.63, 0.97)	0.75 (0.54, 0.94)			0.55 (0.52, 0.6)	0.5 (0.5, 0.5)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0 (0, 0.107)	0.027 (0, 0.081)			0.028 (0, 0.079)	0.029 (0, 0.066)			0.021 (0, 0.084)	0 (0, 0.097)			0.053 (0.011, 0.095)	0 (0, 0.085)			0.036 (0, 0.091)	0.027 (0, 0.088)			0.031 (0, 0.065)	0.031 (0, 0.078)			0 (0, 0.166)	0.057 (0, 0.317)			0 (0, 0)	0.342 (0.123, 1.138)
TEfus+	TC5	count			1	1			1	1			1	1			1	1			1	1			1	1			1	1			1	1
TEfus+	TC5	time			12 (12, 12)	12 (12, 12)			12 (12, 12)	12 (12, 12)			12 (12, 12)	12 (12, 12)			12 (12, 12)	12 (12, 12)			12 (12, 12)	12 (12, 12)			12 (12, 12)	12 (12, 12)			12 (12, 12)	12 (12, 12)			12 (12, 12)	12 (12, 12)
TEfus+	TC5	n			1 (1, 1)	5 (5, 5)			1 (1, 1)	2 (2, 2)			1 (1, 1)	0 (0, 0)			0 (0, 0)	2 (2, 2)			2 (2, 2)	0 (0, 0)			8 (8, 8)	4 (4, 4)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.52 (0.52, 0.52)	0.58 (0.58, 0.58)			NA (NA, NA)	0.51 (0.51, 0.51)			0.63 (0.63, 0.63)	NA (NA, NA)			NA (NA, NA)	0.56 (0.56, 0.56)			0.56 (0.56, 0.56)	NA (NA, NA)			0.74 (0.74, 0.74)	0.57 (0.57, 0.57)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0 (0, 0)	0.049 (0.049, 0.049)			0 (0, 0)	0.066 (0.066, 0.066)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	0 (0, 0)			0 (0, 0)	NA (NA, NA)			0.114 (0.114, 0.114)	0.046 (0.046, 0.046)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC2	count		173		173		173		173		173		173		173		173		173		173		173		173		173		173		173		173
PI3K+	TC2	time		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)		20 (14, 31)
PI3K+	TC2	n		6 (2, 15)		2 (0, 6)		8 (3, 15)		6 (2, 13)		0 (0, 0)		1 (0, 3)		0 (0, 2)		1 (0, 2)		1 (0, 3)		2 (0, 4)		0 (0, 0)		5 (2, 10)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.8 (0.57, 0.97)		0.68 (0.52, 0.86)		0.79 (0.59, 0.96)		0.77 (0.54, 0.95)		NA (NA, NA)		0.59 (0.52, 0.81)		0.57 (0.52, 0.73)		0.57 (0.51, 0.76)		0.56 (0.52, 0.7)		0.6 (0.52, 0.74)		0.53 (0.53, 0.53)		0.75 (0.56, 0.95)		NA (NA, NA)		0.52 (0.52, 0.52)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.032 (0, 0.069)		0.031 (0, 0.079)		0.034 (0, 0.072)		0.035 (0, 0.077)		0 (0, 0)		0 (0, 0.099)		0 (0, 0.112)		0 (0, 0.09)		0 (0, 0.12)		0.024 (0, 0.096)		0.048 (0, 0.101)		0.029 (0, 0.076)		0.199 (0, 1.227)		0.114 (0, 0.406)		0 (0, 0)		0.061 (0, 0.829)

Futility:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37	37
all	TC1	time	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)	16 (3, 31)
all	TC1	n	19 (13, 30)	4 (1, 13)	1 (0, 3)	2 (0, 4)	5 (3, 12)	3 (0, 10)	1 (0, 4)	3 (0, 9)	1 (0, 8)	0 (0, 0)	0 (0, 5)	0 (0, 2)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)	1 (0, 3)	0 (0, 1)	1 (0, 3)	1 (0, 3)	0 (0, 2)	0 (0, 0)	3 (0, 7)	2 (0, 6)	0 (0, 3)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.23 (0.03, 0.41)	0.33 (0.14, 0.48)	0.43 (0.33, 0.48)	0.4 (0.21, 0.48)	0.4 (0.22, 0.48)	0.29 (0.17, 0.46)	0.42 (0.29, 0.49)	0.34 (0.15, 0.47)	0.32 (0.2, 0.45)	NA (NA, NA)	0.38 (0.25, 0.49)	0.39 (0.25, 0.47)	NA (NA, NA)	0.46 (0.33, 0.48)	NA (NA, NA)	0.43 (0.34, 0.45)	0.4 (0.25, 0.47)	0.44 (0.38, 0.49)	0.39 (0.28, 0.46)	0.39 (0.31, 0.44)	0.46 (0.4, 0.47)	NA (NA, NA)	0.34 (0.15, 0.45)	0.35 (0.21, 0.48)	0.39 (0.22, 0.48)	NA (NA, NA)	0.44 (0.44, 0.44)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.124 (0.085, 0.167)	0.162 (0.065, 0.675)	0.205 (0.015, 0.708)	0.272 (0.054, 1.267)	0.113 (0.026, 0.3)	0.161 (0.049, 0.439)	0.153 (0, 0.589)	0.165 (0.09, 0.546)	0.135 (0.103, 0.389)	NA (NA, NA)	0.136 (0.074, 0.307)	0.22 (0.119, 1.606)	NA (NA, NA)	0.24 (0.082, 2.269)	0.107 (0.107, 0.107)	0.119 (0, 1.307)	0.219 (0.05, 0.361)	0.178 (0, 0.321)	0.255 (0.11, 1.793)	0.181 (0, 0.769)	0.181 (0, 0.385)	NA (NA, NA)	0.14 (0, 0.363)	0.128 (0, 0.502)	0.151 (0.037, 0.335)	0.041 (0.008, 0.074)	0.4 (0.215, 1.503)	0.091 (0.091, 0.091)	0.198 (0.198, 0.198)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17
all	TC3	time	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)	28 (11, 35)
all	TC3	n	14 (8, 43)	6 (3, 15)	0 (0, 3)	2 (1, 4)	5 (3, 7)	4 (2, 11)	2 (0, 5)	3 (1, 7)	4 (2, 12)	0 (0, 0)	4 (2, 6)	1 (0, 2)	0 (0, 0)	2 (0, 2)	0 (0, 0)	0 (0, 3)	2 (0, 4)	0 (0, 1)	3 (0, 5)	0 (0, 2)	0 (0, 1)	0 (0, 0)	3 (1, 8)	5 (1, 8)	4 (1, 6)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.15 (0.03, 0.41)	0.32 (0.1, 0.47)	0.4 (0.36, 0.48)	0.35 (0.2, 0.46)	0.31 (0.13, 0.44)	0.28 (0.18, 0.47)	0.35 (0.21, 0.44)	0.34 (0.19, 0.49)	0.29 (0.15, 0.44)	NA (NA, NA)	0.34 (0.18, 0.44)	0.4 (0.28, 0.49)	NA (NA, NA)	0.42 (0.32, 0.49)	NA (NA, NA)	0.45 (0.36, 0.49)	0.34 (0.32, 0.44)	0.42 (0.32, 0.46)	0.4 (0.25, 0.47)	0.41 (0.32, 0.47)	0.47 (0.46, 0.47)	NA (NA, NA)	0.34 (0.24, 0.42)	0.33 (0.17, 0.49)	0.39 (0.25, 0.45)	NA (NA, NA)	0.45 (0.42, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0.118 (0.087, 0.156)	0.121 (0.09, 0.195)	0.135 (0.062, 0.222)	0.199 (0.072, 0.444)	0.158 (0.091, 0.312)	0.15 (0.107, 0.268)	0.215 (0.122, 0.465)	0.129 (0.065, 0.296)	0.141 (0.114, 0.423)	0.202 (0.202, 0.202)	0.141 (0.084, 0.265)	0.17 (0.057, 0.483)	0.137 (0.113, 0.161)	0.181 (0.069, 0.71)	0 (0, 0)	0.267 (0.074, 0.905)	0.158 (0.111, 0.297)	0.322 (0.164, 0.836)	0.107 (0.069, 0.242)	0.19 (0.138, 1.978)	0.167 (0.033, 0.221)	NA (NA, NA)	0.166 (0.097, 0.762)	0.149 (0.075, 0.634)	0.139 (0.07, 0.431)	NA (NA, NA)	0.201 (0.089, 0.692)	NA (NA, NA)	NA (NA, NA)	0.236 (0.145, 0.327)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23
all	TC4	time	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)	26 (9, 35)
all	TC4	n	15 (4, 50)	6 (1, 12)	0 (0, 4)	3 (0, 7)	5 (3, 12)	5 (3, 11)	2 (0, 4)	3 (1, 6)	7 (3, 14)	0 (0, 0)	4 (2, 6)	2 (0, 3)	0 (0, 0)	1 (0, 3)	0 (0, 0)	0 (0, 3)	1 (0, 5)	0 (0, 2)	2 (0, 6)	1 (0, 2)	0 (0, 1)	0 (0, 0)	4 (2, 12)	4 (2, 6)	3 (1, 6)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.18 (0.03, 0.35)	0.33 (0.12, 0.41)	0.43 (0.36, 0.47)	0.38 (0.25, 0.47)	0.31 (0.12, 0.48)	0.24 (0.14, 0.44)	0.38 (0.25, 0.45)	0.33 (0.2, 0.48)	0.3 (0.1, 0.42)	NA (NA, NA)	0.38 (0.23, 0.49)	0.38 (0.3, 0.49)	NA (NA, NA)	0.39 (0.27, 0.49)	NA (NA, NA)	0.44 (0.36, 0.47)	0.42 (0.24, 0.48)	0.47 (0.43, 0.48)	0.38 (0.25, 0.46)	0.42 (0.34, 0.49)	0.43 (0.34, 0.47)	NA (NA, NA)	0.38 (0.17, 0.47)	0.34 (0.18, 0.47)	0.42 (0.28, 0.46)	NA (NA, NA)	0.48 (0.44, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0.139 (0.086, 0.353)	0.12 (0.097, 0.539)	0.16 (0.101, 0.354)	0.14 (0.098, 0.322)	0.132 (0.096, 0.259)	0.172 (0.096, 0.329)	0.156 (0.095, 0.348)	0.152 (0.089, 0.562)	0.16 (0.084, 0.323)	NA (NA, NA)	0.163 (0.091, 0.31)	0.2 (0.055, 0.306)	0.213 (0.213, 0.213)	0.149 (0.042, 0.372)	NA (NA, NA)	0.174 (0.07, 0.734)	0.156 (0.071, 0.412)	0.19 (0.118, 0.331)	0.176 (0.062, 0.635)	0.222 (0.081, 1.215)	0.222 (0.086, 0.455)	0 (0, 0)	0.143 (0.096, 0.371)	0.141 (0.093, 0.252)	0.161 (0.089, 0.855)	NA (NA, NA)	0.156 (0.067, 0.185)	0.087 (0.087, 0.087)	0.088 (0.088, 0.088)	4.218 (4.218, 4.218)	0.112 (0.112, 0.112)	NA (NA, NA)
all	TC5	count	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26
all	TC5	time	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)	24 (10, 34)
all	TC5	n	10 (6, 54)	8 (6, 14)	1 (0, 2)	4 (2, 6)	4 (2, 14)	6 (4, 11)	2 (0, 3)	6 (2, 8)	5 (0, 8)	0 (0, 0)	2 (0, 6)	0 (0, 3)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)	1 (0, 3)	0 (0, 1)	2 (0, 4)	1 (0, 2)	0 (0, 2)	0 (0, 0)	3 (0, 6)	4 (2, 8)	2 (0, 6)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.11 (0.03, 0.39)	0.28 (0.1, 0.46)	0.44 (0.38, 0.48)	0.32 (0.18, 0.48)	0.33 (0.2, 0.41)	0.32 (0.11, 0.45)	0.4 (0.2, 0.47)	0.34 (0.19, 0.45)	0.36 (0.09, 0.47)	NA (NA, NA)	0.32 (0.24, 0.43)	0.47 (0.44, 0.49)	NA (NA, NA)	0.44 (0.3, 0.49)	NA (NA, NA)	0.41 (0.33, 0.47)	0.42 (0.35, 0.47)	0.45 (0.4, 0.48)	0.38 (0.29, 0.45)	0.42 (0.36, 0.49)	0.48 (0.41, 0.49)	NA (NA, NA)	0.3 (0.16, 0.42)	0.25 (0.12, 0.43)	0.35 (0.23, 0.45)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.142 (0.093, 0.286)	0.135 (0.088, 0.24)	0.237 (0.1, 0.744)	0.156 (0.094, 0.424)	0.14 (0.1, 0.326)	0.144 (0.081, 0.264)	0.152 (0.091, 0.293)	0.123 (0.087, 0.518)	0.141 (0.096, 0.317)	NA (NA, NA)	0.228 (0.098, 0.696)	0.12 (0.047, 0.258)	NA (NA, NA)	0.216 (0, 0.696)	0.122 (0.122, 0.122)	0.199 (0.079, 1.024)	0.126 (0.091, 0.547)	0.242 (0.089, 0.676)	0.229 (0.092, 0.565)	0.22 (0.061, 1.261)	0.224 (0.004, 0.788)	0 (0, 0)	0.165 (0.117, 0.535)	0.162 (0.087, 0.367)	0.159 (0.091, 0.961)	NA (NA, NA)	0 (0, 0.108)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	250	250	250	250					250	250	250	250
AR- & TP53-	TC1	time	18 (7, 32)	18 (7, 32)	18 (7, 32)	18 (7, 32)					18 (7, 32)	18 (7, 32)	18 (7, 32)	18 (7, 32)
AR- & TP53-	TC1	n	22 (15, 53)	6 (2, 15)	2 (0, 4)	3 (1, 8)					4 (0, 15)	0 (0, 0)	3 (0, 7)	1 (0, 3)
AR- & TP53-	TC1	post_p	0.13 (0.01, 0.39)	0.36 (0.13, 0.48)	0.43 (0.32, 0.49)	0.4 (0.21, 0.48)					0.37 (0.17, 0.48)	0.47 (0.44, 0.49)	0.41 (0.24, 0.49)	0.43 (0.28, 0.49)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.119 (0.092, 0.156)	0.136 (0.082, 0.305)	0.147 (0, 0.485)	0.145 (0.075, 0.467)					0.141 (0.087, 0.389)	10.787 (0.469, 75.756)	0.144 (0.076, 0.456)	0.166 (0, 0.579)
AR- & TP53-	TC3	count	232	232	232	232					232	232	232	232
AR- & TP53-	TC3	time	22 (12, 33)	22 (12, 33)	22 (12, 33)	22 (12, 33)					22 (12, 33)	22 (12, 33)	22 (12, 33)	22 (12, 33)
AR- & TP53-	TC3	n	19 (8, 63)	7 (3, 17)	2 (0, 4)	3 (1, 9)					7 (4, 16)	0 (0, 0)	4 (1, 9)	2 (0, 4)
AR- & TP53-	TC3	post_p	0.16 (0.03, 0.43)	0.32 (0.12, 0.47)	0.44 (0.31, 0.49)	0.39 (0.23, 0.48)					0.31 (0.12, 0.46)	NA (NA, NA)	0.36 (0.16, 0.48)	0.42 (0.27, 0.48)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.116 (0.092, 0.171)	0.133 (0.09, 0.35)	0.146 (0.063, 0.462)	0.154 (0.093, 0.447)					0.131 (0.089, 0.28)	0 (0, 0.244)	0.156 (0.09, 0.489)	0.176 (0.08, 0.505)
AR- & TP53-	TC4	count	213	213	213	213					213	213	213	213
AR- & TP53-	TC4	time	21 (12, 33)	21 (12, 33)	21 (12, 33)	21 (12, 33)					21 (12, 33)	21 (12, 33)	21 (12, 33)	21 (12, 33)
AR- & TP53-	TC4	n	17 (7, 68)	6 (2, 21)	1 (0, 4)	3 (1, 8)					7 (4, 16)	0 (0, 0)	4 (2, 7)	2 (0, 4)
AR- & TP53-	TC4	post_p	0.2 (0.02, 0.44)	0.34 (0.12, 0.47)	0.42 (0.29, 0.49)	0.4 (0.23, 0.49)					0.33 (0.1, 0.47)	NA (NA, NA)	0.38 (0.21, 0.49)	0.43 (0.31, 0.49)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.122 (0.093, 0.204)	0.131 (0.088, 0.382)	0.168 (0.059, 0.645)	0.142 (0.08, 0.459)					0.127 (0.083, 0.253)	0.079 (0, 0.279)	0.148 (0.083, 0.415)	0.154 (0.07, 0.686)
AR- & TP53-	TC5	count	245	245	245	245					245	245	245	245
AR- & TP53-	TC5	time	23 (13, 32)	23 (13, 32)	23 (13, 32)	23 (13, 32)					23 (13, 32)	23 (13, 32)	23 (13, 32)	23 (13, 32)
AR- & TP53-	TC5	n	16 (7, 71)	8 (4, 16)	1 (0, 4)	4 (2, 9)					6 (2, 17)	0 (0, 0)	3 (1, 8)	1 (0, 4)
AR- & TP53-	TC5	post_p	0.16 (0.02, 0.43)	0.28 (0.11, 0.47)	0.43 (0.32, 0.48)	0.36 (0.19, 0.49)					0.34 (0.13, 0.47)	0.47 (0.47, 0.47)	0.39 (0.22, 0.48)	0.43 (0.3, 0.49)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.125 (0.092, 0.244)	0.125 (0.091, 0.246)	0.17 (0.076, 0.692)	0.143 (0.086, 0.386)					0.138 (0.093, 0.336)	1.355 (0.621, 2.089)	0.163 (0.089, 0.589)	0.151 (0.067, 0.578)
HRD+	TC1	count									53	53	53	53	53	53	53	53									53	53	53	53	53	53	53	53
HRD+	TC1	time									32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)									32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)	32 (24, 35)
HRD+	TC1	n									15 (7, 23)	0 (0, 0)	6 (3, 11)	2 (0, 4)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 4)									3 (1, 6)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.3 (0.1, 0.48)	NA (NA, NA)	0.37 (0.2, 0.46)	0.4 (0.3, 0.49)	NA (NA, NA)	0.43 (0.34, 0.49)	NA (NA, NA)	0.4 (0.32, 0.47)									0.37 (0.2, 0.48)	NA (NA, NA)	0.45 (0.39, 0.48)	NA (NA, NA)	0.41 (0.41, 0.41)	NA (NA, NA)	NA (NA, NA)	0.4 (0.4, 0.4)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.115 (0.087, 0.181)	0.202 (0.202, 0.202)	0.125 (0.08, 0.176)	0.175 (0.089, 0.465)	0.326 (0.188, 0.464)	0.166 (0.085, 0.655)	0.114 (0.023, 0.206)	0.181 (0.084, 0.505)									0.169 (0.082, 0.591)	0.113 (0.088, 0.943)	0.138 (0, 1.605)	NA (NA, NA)	0.127 (0, 0.489)	NA (NA, NA)	5.852 (5.852, 5.852)	0.071 (0.014, 0.145)
HRD+	TC3	count									96	96	96	96	96	96	96	96									96	96	96	96	96	96	96	96
HRD+	TC3	time									27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)									27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)	27 (20, 35)
HRD+	TC3	n									12 (6, 18)	0 (0, 0)	6 (3, 10)	2 (1, 6)	0 (0, 0)	1 (0, 3)	0 (0, 0)	2 (0, 4)									4 (2, 7)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.31 (0.09, 0.45)	NA (NA, NA)	0.36 (0.17, 0.48)	0.43 (0.28, 0.49)	NA (NA, NA)	0.44 (0.31, 0.48)	0.48 (0.48, 0.48)	0.44 (0.35, 0.48)									0.38 (0.23, 0.48)	NA (NA, NA)	0.42 (0.39, 0.47)	NA (NA, NA)	0.44 (0.44, 0.44)	0.47 (0.47, 0.47)	NA (NA, NA)	0.45 (0.45, 0.45)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.118 (0.09, 0.209)	4.187 (0, 23.441)	0.128 (0.097, 0.261)	0.165 (0.084, 0.475)	0.457 (0.457, 0.457)	0.183 (0.082, 0.856)	0.089 (0, 1.611)	0.154 (0.064, 0.727)									0.131 (0.084, 0.305)	NA (NA, NA)	0.162 (0, 0.381)	NA (NA, NA)	0.14 (0, 0.455)	0.182 (0.135, 1.041)	0.466 (0.101, 0.841)	0.305 (0.199, 0.927)
HRD+	TC4	count									102	102	102	102	102	102	102	102									102	102	102	102	102	102	102	102
HRD+	TC4	time									30 (22, 34)	30 (22, 34)	30 (22, 34)	30 (22, 34)	30 (22, 34)	30 (22, 34)	30 (22, 34)	30 (22, 34)									30 (22, 34)	30 (22, 34)	30 (22, 34)	30 (22, 34)	30 (22, 34)	30 (22, 34)	30 (22, 34)	30 (22, 34)
HRD+	TC4	n									12 (7, 20)	0 (0, 0)	6 (3, 11)	2 (1, 6)	0 (0, 0)	1 (0, 4)	0 (0, 0)	2 (0, 4)									4 (2, 8)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.31 (0.1, 0.47)	NA (NA, NA)	0.36 (0.17, 0.48)	0.4 (0.28, 0.49)	NA (NA, NA)	0.42 (0.31, 0.49)	NA (NA, NA)	0.41 (0.34, 0.47)									0.35 (0.21, 0.48)	NA (NA, NA)	0.44 (0.38, 0.48)	0.44 (0.44, 0.44)	0.44 (0.41, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.114 (0.085, 0.179)	0.076 (0.015, 0.216)	0.131 (0.087, 0.289)	0.146 (0.073, 0.374)	0.88 (0.204, 2.496)	0.166 (0.062, 0.586)	0.103 (0.083, 1.165)	0.166 (0.072, 0.748)									0.141 (0.085, 0.466)	0.534 (0.207, 0.867)	0.151 (0.048, 0.604)	0.313 (0.052, 0.984)	0.368 (0.107, 1.419)	0.057 (0.011, 0.061)	0.183 (0.077, 0.289)	0 (0, 0.158)
HRD+	TC5	count									62	62	62	62	62	62	62	62									62	62	62	62	62	62	62	62
HRD+	TC5	time									31 (25, 36)	31 (25, 36)	31 (25, 36)	31 (25, 36)	31 (25, 36)	31 (25, 36)	31 (25, 36)	31 (25, 36)									31 (25, 36)	31 (25, 36)	31 (25, 36)	31 (25, 36)	31 (25, 36)	31 (25, 36)	31 (25, 36)	31 (25, 36)
HRD+	TC5	n									15 (6, 24)	0 (0, 0)	6 (3, 13)	2 (0, 4)	0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 3)									3 (1, 6)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.29 (0.11, 0.45)	0.49 (0.49, 0.49)	0.38 (0.26, 0.48)	0.43 (0.24, 0.49)	NA (NA, NA)	0.41 (0.36, 0.49)	0.49 (0.49, 0.49)	0.4 (0.3, 0.49)									0.35 (0.2, 0.48)	NA (NA, NA)	0.42 (0.35, 0.45)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.116 (0.087, 0.198)	0 (0, 0)	0.128 (0.091, 0.225)	0.151 (0.083, 0.505)	1.871 (1.452, 2.291)	0.21 (0.052, 0.921)	0.18 (0.036, 0.323)	0.18 (0.076, 0.42)									0.159 (0.09, 0.485)	0.071 (0.071, 0.071)	0.321 (0.1, 1.077)	NA (NA, NA)	0.115 (0, 1.638)	0.17 (0.17, 0.17)	0.076 (0.015, 0.144)	NA (NA, NA)
TP53+	TC1	count					182	182	182	182					182	182	182	182					182	182	182	182					182	182	182	182
TP53+	TC1	time					24 (15, 34)	24 (15, 34)	24 (15, 34)	24 (15, 34)					24 (15, 34)	24 (15, 34)	24 (15, 34)	24 (15, 34)					24 (15, 34)	24 (15, 34)	24 (15, 34)	24 (15, 34)					24 (15, 34)	24 (15, 34)	24 (15, 34)	24 (15, 34)
TP53+	TC1	n					8 (4, 16)	6 (3, 14)	3 (1, 5)	5 (2, 12)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					0 (0, 2)	0 (0, 0)	6 (2, 13)	4 (2, 11)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.31 (0.13, 0.46)	0.28 (0.11, 0.46)	0.4 (0.25, 0.48)	0.32 (0.15, 0.48)					NA (NA, NA)	0.43 (0.31, 0.49)	NA (NA, NA)	0.45 (0.34, 0.48)					0.45 (0.39, 0.49)	NA (NA, NA)	0.33 (0.12, 0.46)	0.35 (0.18, 0.48)					0.47 (0.46, 0.49)	NA (NA, NA)	NA (NA, NA)	0.38 (0.38, 0.38)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.123 (0.083, 0.221)	0.143 (0.094, 0.298)	0.166 (0.082, 0.446)	0.143 (0.088, 0.384)					0.174 (0.035, 0.576)	0.159 (0, 0.963)	0.853 (0.171, 1.536)	0.136 (0, 0.502)					0.184 (0, 0.942)	0.315 (0.063, 0.567)	0.142 (0.092, 0.395)	0.141 (0.084, 0.46)					0.072 (0, 0.803)	0.4 (0.124, 0.727)	0.36 (0.168, 2.724)	0.071 (0.071, 0.071)
TP53+	TC3	count					156	156	156	156					156	156	156	156					156	156	156	156					156	156	156	156
TP53+	TC3	time					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)					24 (16, 32)	24 (16, 32)	24 (16, 32)	24 (16, 32)
TP53+	TC3	n					6 (3, 14)	7 (3, 13)	2 (0, 5)	4 (2, 10)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					0 (0, 2)	0 (0, 0)	5 (2, 11)	4 (2, 10)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.32 (0.14, 0.48)	0.33 (0.14, 0.48)	0.39 (0.25, 0.48)	0.35 (0.19, 0.47)					NA (NA, NA)	0.42 (0.33, 0.49)	0.46 (0.46, 0.46)	0.45 (0.33, 0.48)					0.45 (0.38, 0.49)	NA (NA, NA)	0.33 (0.15, 0.47)	0.32 (0.18, 0.47)					0.44 (0.42, 0.46)	0.49 (0.49, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.127 (0.087, 0.252)	0.126 (0.088, 0.283)	0.174 (0.086, 0.658)	0.145 (0.094, 0.413)					0.054 (0, 0.693)	0.186 (0.045, 0.737)	0.122 (0, 2.967)	0.167 (0.049, 0.652)					0.165 (0, 0.423)	0.182 (0.017, 0.428)	0.14 (0.084, 0.311)	0.149 (0.093, 0.353)					0.129 (0, 0.769)	0.182 (0, 0.644)	0.064 (0, 0.67)	0.153 (0.044, 0.261)
TP53+	TC4	count					165	165	165	165					165	165	165	165					165	165	165	165					165	165	165	165
TP53+	TC4	time					25 (16, 34)	25 (16, 34)	25 (16, 34)	25 (16, 34)					25 (16, 34)	25 (16, 34)	25 (16, 34)	25 (16, 34)					25 (16, 34)	25 (16, 34)	25 (16, 34)	25 (16, 34)					25 (16, 34)	25 (16, 34)	25 (16, 34)	25 (16, 34)
TP53+	TC4	n					7 (4, 17)	6 (3, 16)	2 (0, 5)	4 (2, 11)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					0 (0, 2)	0 (0, 0)	6 (2, 14)	5 (2, 9)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.31 (0.11, 0.47)	0.33 (0.14, 0.47)	0.43 (0.26, 0.49)	0.34 (0.17, 0.48)					NA (NA, NA)	0.41 (0.27, 0.49)	NA (NA, NA)	0.43 (0.32, 0.48)					0.44 (0.39, 0.48)	NA (NA, NA)	0.35 (0.16, 0.46)	0.34 (0.16, 0.48)					0.46 (0.42, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.126 (0.086, 0.241)	0.13 (0.085, 0.27)	0.15 (0.06, 0.434)	0.147 (0.091, 0.486)					0.152 (0, 0.248)	0.16 (0.053, 0.604)	0.087 (0.014, 0.192)	0.163 (0.062, 0.701)					0.161 (0, 0.721)	0 (0, 0.373)	0.129 (0.09, 0.345)	0.149 (0.092, 0.328)					0.355 (0.026, 1.083)	0.065 (0.046, 2.579)	0 (0, 0.199)	0.565 (0.401, 0.729)
TP53+	TC5	count					177	177	177	177					177	177	177	177					177	177	177	177					177	177	177	177
TP53+	TC5	time					23 (13, 34)	23 (13, 34)	23 (13, 34)	23 (13, 34)					23 (13, 34)	23 (13, 34)	23 (13, 34)	23 (13, 34)					23 (13, 34)	23 (13, 34)	23 (13, 34)	23 (13, 34)					23 (13, 34)	23 (13, 34)	23 (13, 34)	23 (13, 34)
TP53+	TC5	n					6 (3, 15)	7 (3, 13)	2 (0, 5)	6 (3, 10)					0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 2)					0 (0, 1)	0 (0, 0)	4 (2, 10)	4 (2, 11)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.32 (0.11, 0.47)	0.3 (0.13, 0.46)	0.41 (0.25, 0.48)	0.34 (0.14, 0.47)					NA (NA, NA)	0.44 (0.31, 0.49)	NA (NA, NA)	0.44 (0.29, 0.49)					0.47 (0.41, 0.5)	NA (NA, NA)	0.33 (0.14, 0.47)	0.35 (0.15, 0.48)					0.45 (0.44, 0.49)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.138 (0.087, 0.301)	0.135 (0.087, 0.292)	0.159 (0.086, 0.578)	0.132 (0.08, 0.25)					0.113 (0.089, 0.211)	0.195 (0, 1.361)	0.181 (0.037, 0.298)	0.16 (0, 0.486)					0.167 (0, 0.987)	0.064 (0.013, 0.088)	0.145 (0.093, 0.432)	0.137 (0.084, 0.37)					0.079 (0, 0.78)	0 (0, 0.101)	0.076 (0, 0.572)	0.223 (0.223, 0.223)
TEfus+	TC1	count			78	78			78	78			78	78			78	78			78	78			78	78			78	78			78	78
TEfus+	TC1	time			27 (17, 35)	27 (17, 35)			27 (17, 35)	27 (17, 35)			27 (17, 35)	27 (17, 35)			27 (17, 35)	27 (17, 35)			27 (17, 35)	27 (17, 35)			27 (17, 35)	27 (17, 35)			27 (17, 35)	27 (17, 35)			27 (17, 35)	27 (17, 35)
TEfus+	TC1	n			2 (0, 5)	3 (1, 8)			2 (1, 5)	5 (2, 11)			4 (0, 10)	1 (0, 3)			0 (0, 0)	1 (0, 3)			2 (1, 5)	2 (0, 3)			4 (2, 11)	4 (1, 8)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.42 (0.26, 0.49)	0.35 (0.16, 0.45)			0.4 (0.26, 0.48)	0.31 (0.16, 0.47)			0.36 (0.19, 0.49)	0.42 (0.3, 0.48)			NA (NA, NA)	0.44 (0.34, 0.47)			0.37 (0.24, 0.47)	0.42 (0.33, 0.47)			0.27 (0.12, 0.44)	0.35 (0.17, 0.46)			0.45 (0.36, 0.47)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.147 (0.071, 0.424)	0.149 (0.099, 0.544)			0.164 (0.084, 0.5)	0.138 (0.087, 0.344)			0.132 (0.084, 0.319)	0.182 (0.077, 0.576)			0.168 (0.119, 0.217)	0.122 (0.03, 0.457)			0.168 (0.095, 0.461)	0.182 (0.055, 0.686)			0.146 (0.097, 0.488)	0.147 (0.092, 0.451)			0.191 (0, 0.618)	0.091 (0.091, 0.091)			NA (NA, NA)	0.197 (0.096, 0.298)
TEfus+	TC3	count			72	72			72	72			72	72			72	72			72	72			72	72			72	72			72	72
TEfus+	TC3	time			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)			26 (17, 34)	26 (17, 34)
TEfus+	TC3	n			1 (0, 4)	3 (1, 8)			2 (0, 5)	4 (2, 9)			4 (1, 9)	2 (0, 4)			0 (0, 0)	1 (0, 3)			3 (1, 5)	1 (0, 3)			5 (2, 10)	4 (2, 9)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.44 (0.29, 0.48)	0.35 (0.19, 0.48)			0.38 (0.18, 0.47)	0.34 (0.18, 0.47)			0.37 (0.16, 0.48)	0.42 (0.32, 0.48)			NA (NA, NA)	0.44 (0.38, 0.48)			0.41 (0.27, 0.49)	0.42 (0.3, 0.47)			0.32 (0.14, 0.46)	0.3 (0.14, 0.47)			0.44 (0.41, 0.48)	NA (NA, NA)			NA (NA, NA)	0.41 (0.41, 0.41)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.169 (0.078, 0.569)	0.159 (0.094, 0.443)			0.183 (0.096, 0.515)	0.157 (0.097, 0.413)			0.141 (0.084, 0.295)	0.17 (0.077, 0.505)			0 (0, 0)	0.168 (0.059, 0.751)			0.133 (0.075, 0.358)	0.156 (0.052, 0.388)			0.133 (0.084, 0.277)	0.159 (0.093, 0.39)			0.194 (0, 0.733)	0.122 (0.122, 0.122)			0.138 (0.028, 0.655)	0.305 (0.188, 0.927)
TEfus+	TC4	count			69	69			69	69			69	69			69	69			69	69			69	69			69	69			69	69
TEfus+	TC4	time			26 (16, 35)	26 (16, 35)			26 (16, 35)	26 (16, 35)			26 (16, 35)	26 (16, 35)			26 (16, 35)	26 (16, 35)			26 (16, 35)	26 (16, 35)			26 (16, 35)	26 (16, 35)			26 (16, 35)	26 (16, 35)			26 (16, 35)	26 (16, 35)
TEfus+	TC4	n			1 (0, 4)	3 (1, 8)			2 (0, 5)	4 (2, 8)			4 (2, 7)	2 (0, 5)			0 (0, 0)	1 (0, 3)			2 (1, 6)	1 (0, 3)			6 (2, 14)	4 (1, 7)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.43 (0.32, 0.48)	0.37 (0.24, 0.46)			0.41 (0.3, 0.48)	0.35 (0.18, 0.48)			0.38 (0.22, 0.48)	0.42 (0.28, 0.49)			NA (NA, NA)	0.44 (0.37, 0.49)			0.39 (0.26, 0.48)	0.43 (0.31, 0.49)			0.33 (0.15, 0.47)	0.32 (0.17, 0.46)			0.46 (0.4, 0.49)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.201 (0.102, 1.069)	0.144 (0.088, 0.933)			0.156 (0.096, 0.47)	0.13 (0.079, 0.378)			0.146 (0.076, 0.407)	0.148 (0.059, 0.366)			NA (NA, NA)	0.174 (0.076, 0.539)			0.165 (0.073, 0.862)	0.162 (0.073, 0.59)			0.122 (0.084, 0.297)	0.169 (0.1, 0.476)			0.121 (0, 0.245)	0.2 (0.109, 0.29)			0.112 (0.022, 0.275)	0.385 (0.077, 0.693)
TEfus+	TC5	count			92	92			92	92			92	92			92	92			92	92			92	92			92	92			92	92
TEfus+	TC5	time			24 (17, 35)	24 (17, 35)			24 (17, 35)	24 (17, 35)			24 (17, 35)	24 (17, 35)			24 (17, 35)	24 (17, 35)			24 (17, 35)	24 (17, 35)			24 (17, 35)	24 (17, 35)			24 (17, 35)	24 (17, 35)			24 (17, 35)	24 (17, 35)
TEfus+	TC5	n			1 (0, 4)	4 (2, 7)			2 (0, 4)	6 (3, 10)			3 (1, 9)	1 (0, 4)			0 (0, 0)	0 (0, 2)			2 (1, 5)	1 (0, 3)			5 (2, 11)	4 (3, 10)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.41 (0.3, 0.47)	0.32 (0.18, 0.47)			0.41 (0.28, 0.48)	0.31 (0.15, 0.46)			0.38 (0.23, 0.47)	0.44 (0.3, 0.48)			NA (NA, NA)	0.44 (0.31, 0.49)			0.39 (0.21, 0.48)	0.41 (0.33, 0.47)			0.33 (0.13, 0.46)	0.32 (0.13, 0.44)			0.46 (0.41, 0.49)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0.186 (0.092, 0.849)	0.163 (0.09, 0.457)			0.16 (0.091, 0.813)	0.131 (0.09, 0.268)			0.189 (0.096, 0.788)	0.138 (0.077, 0.484)			0.222 (0.142, 0.302)	0.177 (0, 0.44)			0.195 (0.089, 0.625)	0.264 (0.067, 1.577)			0.128 (0.087, 0.377)	0.144 (0.096, 0.283)			0.109 (0, 0.887)	NA (NA, NA)			0.076 (0.076, 0.076)	NA (NA, NA)
PI3K+	TC1	count		125		125		125		125		125		125		125		125		125		125		125		125		125		125		125		125
PI3K+	TC1	time		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)
PI3K+	TC1	n		7 (3, 21)		4 (1, 9)		7 (3, 14)		6 (3, 12)		0 (0, 0)		1 (0, 3)		1 (0, 3)		1 (0, 3)		1 (0, 2)		1 (0, 4)		0 (0, 0)		5 (1, 11)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.28 (0.11, 0.46)		0.36 (0.18, 0.47)		0.26 (0.13, 0.46)		0.33 (0.15, 0.45)		NA (NA, NA)		0.42 (0.29, 0.49)		0.45 (0.33, 0.49)		0.44 (0.34, 0.48)		0.42 (0.35, 0.48)		0.43 (0.31, 0.48)		NA (NA, NA)		0.33 (0.17, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.128 (0.085, 0.227)		0.156 (0.081, 0.388)		0.135 (0.09, 0.3)		0.136 (0.094, 0.319)		20.482 (20.482, 20.482)		0.159 (0.049, 0.653)		0.196 (0, 1.187)		0.162 (0.053, 1.088)		0.205 (0, 0.695)		0.163 (0.055, 0.73)		0.044 (0.009, 0.079)		0.143 (0.086, 0.421)		0 (0, 0.449)		0.046 (0.009, 0.082)		0.498 (0.391, 0.606)		0.095 (0.019, 0.172)
PI3K+	TC3	count		113		113		113		113		113		113		113		113		113		113		113		113		113		113		113		113
PI3K+	TC3	time		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)
PI3K+	TC3	n		7 (2, 18)		4 (1, 9)		7 (3, 15)		5 (2, 10)		0 (0, 0)		2 (0, 4)		1 (0, 3)		1 (0, 4)		1 (0, 2)		1 (0, 3)		0 (0, 0)		4 (2, 9)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.3 (0.1, 0.45)		0.33 (0.18, 0.46)		0.3 (0.13, 0.46)		0.35 (0.16, 0.48)		NA (NA, NA)		0.41 (0.29, 0.47)		0.42 (0.3, 0.48)		0.44 (0.35, 0.49)		0.45 (0.36, 0.49)		0.42 (0.32, 0.48)		NA (NA, NA)		0.32 (0.18, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.44 (0.44, 0.44)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.13 (0.095, 0.332)		0.154 (0.103, 0.466)		0.132 (0.088, 0.271)		0.142 (0.085, 0.33)		0.202 (0.123, 0.454)		0.164 (0.083, 0.433)		0.183 (0.066, 0.716)		0.147 (0.054, 0.438)		0.133 (0, 0.659)		0.188 (0.03, 0.594)		0.182 (0.017, 0.428)		0.148 (0.093, 0.384)		NA (NA, NA)		0.168 (0.168, 0.168)		0.152 (0.129, 0.176)		1.082 (1.082, 1.082)
PI3K+	TC4	count		122		122		122		122		122		122		122		122		122		122		122		122		122		122		122		122
PI3K+	TC4	time		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)		25 (17, 35)
PI3K+	TC4	n		7 (3, 22)		4 (1, 10)		6 (3, 14)		5 (2, 10)		0 (0, 0)		2 (1, 5)		1 (0, 3)		1 (0, 3)		1 (0, 2)		1 (0, 3)		0 (0, 0)		4 (2, 8)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.3 (0.13, 0.46)		0.39 (0.21, 0.48)		0.33 (0.13, 0.45)		0.34 (0.15, 0.47)		NA (NA, NA)		0.41 (0.28, 0.49)		0.42 (0.3, 0.49)		0.42 (0.3, 0.48)		0.43 (0.36, 0.47)		0.41 (0.33, 0.48)		NA (NA, NA)		0.33 (0.16, 0.46)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.128 (0.088, 0.342)		0.144 (0.084, 0.339)		0.13 (0.095, 0.257)		0.143 (0.09, 0.469)		0.164 (0, 0.287)		0.162 (0.073, 0.674)		0.177 (0.065, 0.631)		0.165 (0.065, 0.731)		0.234 (0.055, 1.522)		0.164 (0.073, 0.581)		0 (0, 0.105)		0.154 (0.095, 0.384)		0.415 (0.116, 0.704)		0.34 (0.154, 0.828)		0 (0, 3.375)		0.565 (0.345, 1.318)
PI3K+	TC5	count		172		172		172		172		172		172		172		172		172		172		172		172		172		172		172		172
PI3K+	TC5	time		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)		19 (10, 33)
PI3K+	TC5	n		8 (5, 16)		4 (2, 9)		7 (3, 13)		6 (3, 10)		0 (0, 0)		1 (0, 4)		0 (0, 2)		0 (0, 2)		1 (0, 2)		1 (0, 4)		0 (0, 0)		4 (2, 11)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.29 (0.09, 0.46)		0.37 (0.17, 0.47)		0.31 (0.13, 0.48)		0.34 (0.15, 0.47)		0.46 (0.45, 0.48)		0.43 (0.32, 0.49)		0.44 (0.31, 0.49)		0.44 (0.33, 0.49)		0.44 (0.38, 0.49)		0.44 (0.31, 0.47)		NA (NA, NA)		0.36 (0.19, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.127 (0.088, 0.219)		0.149 (0.081, 0.444)		0.126 (0.085, 0.315)		0.131 (0.082, 0.243)		1.136 (0.227, 2.045)		0.165 (0.085, 0.567)		0.213 (0, 1.321)		0.139 (0, 0.413)		0.15 (0, 0.593)		0.217 (0.06, 1.093)		0.145 (0, 0.648)		0.144 (0.084, 0.296)		0.071 (0.014, 0.192)		0 (0, 0)		NA (NA, NA)		0.174 (0.135, 0.213)