Setting description

TC2 more effective in all the biomarker signatures

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4 TC5
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
all summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
all effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
AR- & TP53- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
AR- & TP53- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
AR- & TP53- effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
HRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
HRD+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
HRD+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
TP53+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
TP53+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
TEfus+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
TEfus+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
PI3K+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
PI3K+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
PI3K+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4 TC5
—– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—– effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—+- effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—++ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+– effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–++- effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+— effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++– effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+++- effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—- effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–+- effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–++ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+– effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-++- effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++— effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++– effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++++- effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 3 225 0 2 1
AR- & TP53- 4 325 2 4 2
HRD+ 2 40 0 2 1
TP53+ 0 219 0 0 0
TEfus+ 1 146 0 0 1
PI3K+ 0 173 0 0 0
TC1 TC2 TC3 TC4 TC5
all 0.006 0.450 0.000 0.004 0.002
AR- & TP53- 0.008 0.650 0.004 0.008 0.004
HRD+ 0.004 0.080 0.000 0.004 0.002
TP53+ 0.000 0.438 0.000 0.000 0.000
TEfus+ 0.002 0.292 0.000 0.000 0.002
PI3K+ 0.000 0.346 0.000 0.000 0.000
futility (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 37 0 17 23 26
AR- & TP53- 250 0 232 213 245
HRD+ 53 0 96 102 62
TP53+ 182 0 156 165 177
TEfus+ 78 0 72 69 92
PI3K+ 125 0 113 122 172
TC1 TC2 TC3 TC4 TC5
all 0.074 0 0.034 0.046 0.052
AR- & TP53- 0.500 0 0.464 0.426 0.490
HRD+ 0.106 0 0.192 0.204 0.124
TP53+ 0.364 0 0.312 0.330 0.354
TEfus+ 0.156 0 0.144 0.138 0.184
PI3K+ 0.250 0 0.226 0.244 0.344
max sample size (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 0 0
AR- & TP53- 39 71 78 65 61
HRD+ 0 0 0 0 0
TP53+ 0 0 0 0 0
TEfus+ 0 0 0 0 0
PI3K+ 0 0 0 0 0
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.000 0.00 0.000
AR- & TP53- 0.078 0.142 0.156 0.13 0.122
HRD+ 0.000 0.000 0.000 0.00 0.000
TP53+ 0.000 0.000 0.000 0.00 0.000
TEfus+ 0.000 0.000 0.000 0.00 0.000
PI3K+ 0.000 0.000 0.000 0.00 0.000


Operating characteristics

char overall TC1 TC2 TC3 TC4 TC5
err_sign 0.544 0.02 0.524 0.004 0.016 0.01
err_type 0.048 0.02 0.000 0.004 0.016 0.01
pow_sign 0.450 0.00 0.450 0.000 0.000 0.00
pow_type 0.974 0.00 0.974 0.000 0.000 0.00

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4 TC5
all graduation 0 3 225 0 2 1
all futility 0 37 0 17 23 26
all max_n 0 0 0 0 0 0
all n 409 (373, 444) 139 (84, 214) 116 (33, 226) 154 (92, 230) 150 (94, 226) 144 (84, 228)
all n_unique 382 (349, 414) 128 (78, 202) 106 (30, 215) 141 (84, 214) 137 (86, 213) 133 (77, 211)
all time_trial 36 (36, 36) 36 (36, 36) 36 (6, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
all time_stop NA (NA, NA) 14 (3, 31) 10 (5, 28) 28 (11, 35) 24 (8, 35) 23 (8, 34)
all post_p NA (NA, NA) 0 (0, 0.02) 1 (1, 1) 0 (0, 0.01) 0 (0, 0.01) 0 (0, 0.01)
all rate 0.076 (0.071, 0.083) 0.114 (0.1, 0.131) 0.038 (0.032, 0.045) 0.114 (0.101, 0.129) 0.114 (0.102, 0.128) 0.114 (0.101, 0.13)
AR- & TP53- graduation 0 4 325 2 4 2
AR- & TP53- futility 0 250 0 232 213 245
AR- & TP53- max_n 0 39 71 78 65 61
AR- & TP53- n 246 (215, 272) 68 (27, 148) 34 (17, 152) 78 (32, 152) 80 (29, 151) 72 (30, 151)
AR- & TP53- n_unique 231 (200, 256) 63 (26, 138) 31 (16, 144) 73 (29, 143) 73 (26, 143) 66 (27, 142)
AR- & TP53- time_trial 36 (36, 36) 35 (9, 36) 18 (8, 36) 36 (15, 36) 36 (15, 36) 36 (15, 36)
AR- & TP53- time_stop NA (NA, NA) 18 (7, 32) 11 (8, 25) 22 (12, 33) 21 (12, 32) 23 (13, 32)
AR- & TP53- post_p NA (NA, NA) 0.01 (0, 0.09) 1 (0.98, 1) 0.01 (0, 0.09) 0.01 (0, 0.11) 0.01 (0, 0.09)
AR- & TP53- rate 0.076 (0.069, 0.084) 0.116 (0.098, 0.141) 0.038 (0.029, 0.048) 0.115 (0.098, 0.142) 0.115 (0.098, 0.14) 0.115 (0.098, 0.146)
HRD+ graduation 0 2 40 0 2 1
HRD+ futility 0 53 0 96 102 62
HRD+ max_n 0 0 0 0 0 0
HRD+ n 62 (49, 75) 25 (8, 44) 13 (2, 30) 29 (18, 47) 29 (19, 50) 25 (13, 44)
HRD+ n_unique 58 (45, 69) 22 (8, 41) 12 (2, 27) 27 (17, 44) 27 (18, 46) 23 (12, 41)
HRD+ time_trial 36 (36, 36) 36 (35, 36) 36 (36, 36) 36 (27, 36) 36 (29, 36) 36 (35, 36)
HRD+ time_stop NA (NA, NA) 31 (23, 35) 28 (21, 35) 27 (20, 35) 30 (21, 34) 31 (23, 36)
HRD+ post_p NA (NA, NA) 0.14 (0.02, 0.49) 0.97 (0.66, 1) 0.1 (0.01, 0.37) 0.1 (0.01, 0.36) 0.12 (0.01, 0.45)
HRD+ rate 0.076 (0.063, 0.094) 0.116 (0.086, 0.17) 0.038 (0.022, 0.065) 0.115 (0.092, 0.148) 0.115 (0.091, 0.15) 0.113 (0.089, 0.162)
TP53+ graduation 0 0 219 0 0 0
TP53+ futility 0 182 0 156 165 177
TP53+ max_n 0 0 0 0 0 0
TP53+ n 135 (119, 156) 53 (26, 85) 38 (13, 103) 54 (28, 87) 53 (28, 85) 53 (26, 85)
TP53+ n_unique 126 (109, 144) 49 (24, 78) 34 (12, 97) 48 (26, 80) 48 (26, 77) 48 (25, 79)
TP53+ time_trial 36 (36, 36) 36 (19, 36) 36 (14, 36) 36 (20, 36) 36 (21, 36) 36 (17, 36)
TP53+ time_stop NA (NA, NA) 24 (15, 34) 18 (12, 29) 24 (16, 32) 25 (16, 34) 23 (13, 34)
TP53+ post_p NA (NA, NA) 0.03 (0, 0.23) 1 (0.98, 1) 0.03 (0, 0.21) 0.03 (0, 0.21) 0.03 (0, 0.19)
TP53+ rate 0.076 (0.067, 0.089) 0.114 (0.095, 0.146) 0.038 (0.028, 0.048) 0.114 (0.095, 0.144) 0.116 (0.096, 0.146) 0.116 (0.095, 0.144)
TEfus+ graduation 0 1 146 0 0 1
TEfus+ futility 0 78 0 72 69 92
TEfus+ max_n 0 0 0 0 0 0
TEfus+ n 126 (109, 142) 52 (28, 79) 36 (12, 76) 54 (32, 81) 55 (33, 78) 53 (28, 79)
TEfus+ n_unique 116 (100, 133) 47 (25, 73) 34 (11, 70) 50 (29, 74) 50 (30, 72) 49 (26, 72)
TEfus+ time_trial 36 (36, 36) 36 (29, 36) 36 (16, 36) 36 (30, 36) 36 (30, 36) 36 (26, 36)
TEfus+ time_stop NA (NA, NA) 27 (17, 35) 19 (12, 31) 26 (17, 34) 26 (16, 35) 24 (17, 35)
TEfus+ post_p NA (NA, NA) 0.03 (0, 0.25) 1 (0.96, 1) 0.03 (0, 0.19) 0.03 (0, 0.21) 0.03 (0, 0.25)
TEfus+ rate 0.077 (0.066, 0.089) 0.115 (0.094, 0.145) 0.038 (0.028, 0.05) 0.114 (0.097, 0.143) 0.116 (0.096, 0.142) 0.116 (0.094, 0.142)
PI3K+ graduation 0 0 173 0 0 0
PI3K+ futility 0 125 0 113 122 172
PI3K+ max_n 0 0 0 0 0 0
PI3K+ n 132 (114, 151) 52 (26, 85) 28 (9, 70) 54 (30, 82) 53 (29, 84) 54 (28, 86)
PI3K+ n_unique 123 (106, 141) 47 (24, 78) 26 (8, 65) 50 (28, 78) 48 (26, 78) 50 (26, 80)
PI3K+ time_trial 36 (36, 36) 36 (22, 36) 36 (17, 36) 36 (24, 36) 36 (23, 36) 36 (15, 36)
PI3K+ time_stop NA (NA, NA) 25 (16, 35) 20 (14, 31) 26 (17, 34) 25 (17, 35) 19 (10, 33)
PI3K+ post_p NA (NA, NA) 0.03 (0, 0.23) 1 (0.92, 1) 0.03 (0, 0.2) 0.03 (0, 0.2) 0.03 (0, 0.19)
PI3K+ rate 0.077 (0.066, 0.088) 0.115 (0.095, 0.147) 0.038 (0.026, 0.052) 0.115 (0.094, 0.143) 0.116 (0.096, 0.144) 0.115 (0.095, 0.14)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4 TC5
—– graduation 0 7 423 2 6 3
—– futility 0 264 0 233 218 249
—– max_n 0 39 71 78 65 61
—– n 145 (123, 165) 26 (15, 85) 23 (12, 106) 31 (10, 98) 29 (8, 97) 28 (8, 93)
—– n_unique 138 (117, 157) 25 (15, 81) 22 (11, 102) 29 (9, 94) 26 (7, 90) 26 (7, 90)
—– post_p NA (NA, NA) 0.05 (0, 0.23) 1 (0.92, 1) 0.06 (0, 0.28) 0.06 (0, 0.34) 0.06 (0, 0.29)
—– rate 0.076 (0.067, 0.088) 0.118 (0.095, 0.156) 0.039 (0.028, 0.052) 0.116 (0.094, 0.162) 0.119 (0.092, 0.172) 0.119 (0.094, 0.193)
—-+ graduation 0 7 431 2 6 3
—-+ futility 0 299 0 265 252 297
—-+ max_n 0 37 68 76 64 59
—-+ n 32 (24, 41) 9 (3, 26) 4 (1, 15) 9 (3, 26) 10 (3, 26) 10 (5, 27)
—-+ n_unique 30 (22, 39) 8 (3, 24) 3 (0, 13) 8 (3, 24) 9 (3, 25) 9 (4, 25)
—-+ post_p NA (NA, NA) 0.23 (0.08, 0.55) 0.86 (0.49, 0.99) 0.23 (0.07, 0.52) 0.25 (0.08, 0.58) 0.23 (0.07, 0.56)
—-+ rate 0.076 (0.058, 0.101) 0.127 (0.082, 0.248) 0.038 (0.014, 0.089) 0.125 (0.084, 0.268) 0.123 (0.082, 0.296) 0.12 (0.082, 0.227)
—+- graduation 0 8 425 2 6 4
—+- futility 0 278 0 245 229 259
—+- max_n 0 38 71 77 64 60
—+- n 5 (2, 9) 2 (0, 6) 1 (0, 4) 2 (0, 6) 2 (0, 6) 2 (0, 6)
—+- n_unique 5 (2, 9) 2 (0, 5) 1 (0, 3) 2 (0, 5) 2 (0, 5) 2 (0, 5)
—+- post_p NA (NA, NA) 0.43 (0.28, 0.66) 0.65 (0.43, 0.87) 0.43 (0.26, 0.67) 0.43 (0.25, 0.66) 0.42 (0.27, 0.66)
—+- rate 0.081 (0.035, 0.186) 0.129 (0.06, 0.396) 0.047 (0, 0.145) 0.129 (0.054, 0.358) 0.13 (0.054, 0.491) 0.135 (0.052, 0.462)
—++ graduation 0 8 432 2 6 4
—++ futility 0 304 0 272 258 302
—++ max_n 0 36 68 75 63 58
—++ n 14 (9, 20) 5 (1, 13) 2 (0, 6) 5 (1, 13) 5 (1, 13) 5 (2, 13)
—++ n_unique 13 (8, 19) 4 (1, 12) 2 (0, 6) 5 (1, 12) 4 (1, 12) 5 (2, 12)
—++ post_p NA (NA, NA) 0.34 (0.16, 0.64) 0.76 (0.45, 0.94) 0.35 (0.16, 0.63) 0.35 (0.15, 0.68) 0.32 (0.15, 0.59)
—++ rate 0.078 (0.046, 0.119) 0.13 (0.075, 0.357) 0.042 (0, 0.124) 0.135 (0.072, 0.384) 0.127 (0.07, 0.342) 0.132 (0.077, 0.32)
–+– graduation 0 3 363 0 2 1
–+– futility 0 202 0 161 170 183
–+– max_n 0 0 0 0 0 0
–+– n 29 (21, 37) 10 (4, 25) 8 (2, 28) 9 (4, 22) 9 (4, 25) 8 (3, 22)
–+– n_unique 27 (19, 35) 9 (4, 23) 7 (2, 26) 8 (3, 20) 8 (3, 23) 7 (3, 21)
–+– post_p NA (NA, NA) 0.23 (0.08, 0.62) 0.92 (0.62, 1) 0.26 (0.09, 0.59) 0.25 (0.08, 0.58) 0.24 (0.08, 0.57)
–+– rate 0.078 (0.055, 0.109) 0.12 (0.079, 0.223) 0.039 (0.018, 0.071) 0.123 (0.079, 0.254) 0.123 (0.08, 0.243) 0.127 (0.08, 0.249)
–+-+ graduation 0 3 408 0 2 1
–+-+ futility 0 247 0 206 219 255
–+-+ max_n 0 0 0 0 0 0
–+-+ n 28 (20, 36) 8 (3, 23) 6 (1, 21) 9 (4, 24) 8 (4, 23) 9 (4, 22)
–+-+ n_unique 26 (18, 34) 7 (3, 22) 5 (1, 20) 8 (3, 22) 8 (3, 22) 8 (3, 20)
–+-+ post_p NA (NA, NA) 0.23 (0.09, 0.58) 0.88 (0.47, 0.99) 0.26 (0.09, 0.59) 0.26 (0.09, 0.58) 0.25 (0.09, 0.61)
–+-+ rate 0.076 (0.057, 0.105) 0.129 (0.081, 0.302) 0.04 (0.018, 0.094) 0.121 (0.077, 0.266) 0.126 (0.08, 0.258) 0.123 (0.08, 0.23)
–++- graduation 0 4 389 0 2 2
–++- futility 0 229 0 186 194 220
–++- max_n 0 0 0 0 0 0
–++- n 8 (4, 12) 3 (1, 7) 3 (0, 7) 3 (1, 7) 3 (1, 6) 3 (1, 7)
–++- n_unique 7 (4, 11) 3 (1, 6) 2 (0, 7) 3 (1, 6) 3 (1, 6) 3 (1, 6)
–++- post_p NA (NA, NA) 0.38 (0.22, 0.67) 0.72 (0.4, 0.93) 0.4 (0.21, 0.64) 0.41 (0.22, 0.65) 0.39 (0.23, 0.64)
–++- rate 0.077 (0.038, 0.145) 0.13 (0.055, 0.384) 0.042 (0.012, 0.131) 0.134 (0.057, 0.453) 0.13 (0.06, 0.38) 0.13 (0.058, 0.421)
–+++ graduation 0 4 421 0 2 2
–+++ futility 0 263 0 223 233 276
–+++ max_n 0 0 0 0 0 0
–+++ n 21 (15, 28) 7 (2, 17) 5 (1, 16) 7 (2, 18) 6 (2, 16) 7 (3, 17)
–+++ n_unique 20 (13, 27) 6 (2, 16) 4 (1, 15) 6 (2, 17) 6 (2, 15) 6 (3, 16)
–+++ post_p NA (NA, NA) 0.29 (0.11, 0.61) 0.87 (0.47, 0.99) 0.31 (0.12, 0.64) 0.3 (0.12, 0.57) 0.29 (0.13, 0.63)
–+++ rate 0.077 (0.055, 0.112) 0.129 (0.076, 0.293) 0.039 (0.017, 0.095) 0.128 (0.074, 0.304) 0.128 (0.077, 0.317) 0.122 (0.076, 0.243)
-+— graduation 0 8 429 2 7 4
-+— futility 0 286 0 271 270 280
-+— max_n 0 36 66 76 62 57
-+— n 28 (19, 36) 8 (1, 23) 3 (0, 15) 10 (4, 21) 10 (5, 24) 9 (3, 23)
-+— n_unique 26 (17, 33) 7 (1, 21) 3 (0, 14) 9 (4, 20) 9 (4, 23) 8 (3, 21)
-+— post_p NA (NA, NA) 0.28 (0.11, 0.55) 0.84 (0.52, 0.99) 0.26 (0.08, 0.56) 0.24 (0.08, 0.57) 0.26 (0.08, 0.59)
-+— rate 0.076 (0.056, 0.105) 0.125 (0.084, 0.286) 0.041 (0.015, 0.085) 0.12 (0.082, 0.23) 0.12 (0.081, 0.222) 0.125 (0.081, 0.268)
-+–+ graduation 0 8 437 2 7 3
-+–+ futility 0 315 0 296 298 317
-+–+ max_n 0 34 63 74 61 57
-+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ post_p NA (NA, NA) 0.48 (0.48, 0.51) 0.6 (0.6, 0.6) 0.53 (0.53, 0.53) 0.45 (0.43, 0.47) 0.51 (0.45, 0.56)
-+–+ rate 0.211 (0, 1.259) 0.15 (0, 10.787) 0 (0, 0.048) 0.132 (0, 3.66) 0.171 (0, 0.36) 0.065 (0, 0.471)
-+-+- graduation 0 9 430 2 7 5
-+-+- futility 0 298 0 281 277 287
-+-+- max_n 0 35 66 75 61 56
-+-+- n 13 (8, 18) 4 (0, 12) 1 (0, 5) 6 (2, 12) 5 (2, 12) 5 (1, 12)
-+-+- n_unique 12 (7, 17) 4 (0, 11) 1 (0, 5) 5 (2, 11) 5 (2, 12) 4 (1, 11)
-+-+- post_p NA (NA, NA) 0.37 (0.19, 0.69) 0.75 (0.39, 0.93) 0.33 (0.14, 0.62) 0.36 (0.17, 0.66) 0.36 (0.19, 0.66)
-+-+- rate 0.079 (0.047, 0.121) 0.125 (0.059, 0.318) 0.04 (0, 0.157) 0.132 (0.075, 0.322) 0.123 (0.068, 0.286) 0.129 (0.07, 0.383)
-+-++ graduation 0 9 437 2 7 4
-+-++ futility 0 320 0 302 301 320
-+-++ max_n 0 33 63 73 60 56
-+-++ n 5 (2, 9) 2 (0, 6) 0 (0, 3) 2 (1, 6) 3 (1, 6) 2 (0, 5)
-+-++ n_unique 5 (2, 9) 1 (0, 5) 0 (0, 2) 2 (0, 6) 2 (0, 6) 2 (0, 5)
-+-++ post_p NA (NA, NA) 0.43 (0.27, 0.68) 0.63 (0.42, 0.82) 0.42 (0.25, 0.64) 0.42 (0.26, 0.64) 0.43 (0.28, 0.66)
-+-++ rate 0.076 (0.035, 0.167) 0.127 (0.05, 0.433) 0.048 (0, 0.185) 0.141 (0.058, 0.484) 0.131 (0.056, 0.466) 0.129 (0.05, 0.438)
-++– graduation 0 5 377 0 4 2
-++– futility 0 234 0 219 228 215
-++– max_n 0 0 0 0 0 0
-++– n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– post_p NA (NA, NA) 0.5 (0.5, 0.5) 0.54 (0.54, 0.54) 0.53 (0.51, 0.55) 0.56 (0.56, 0.56) NA (NA, NA)
-++– rate 0.234 (0, 0.66) 0.174 (0, 0.992) 0.041 (0, 0.155) 0.167 (0, 1.294) 0.148 (0, 0.896) 0.237 (0, 1.533)
-++-+ graduation 0 5 420 0 4 1
-++-+ futility 0 267 0 255 266 273
-++-+ max_n 0 0 0 0 0 0
-++-+ n 3 (1, 6) 1 (0, 4) 0 (0, 3) 2 (0, 4) 2 (0, 4) 1 (0, 4)
-++-+ n_unique 3 (1, 5) 1 (0, 3) 0 (0, 2) 2 (0, 4) 1 (0, 4) 1 (0, 3)
-++-+ post_p NA (NA, NA) 0.44 (0.31, 0.65) 0.61 (0.44, 0.8) 0.45 (0.32, 0.64) 0.45 (0.3, 0.65) 0.45 (0.29, 0.63)
-++-+ rate 0.085 (0, 0.25) 0.152 (0.045, 0.577) 0.033 (0, 0.191) 0.144 (0.045, 0.567) 0.141 (0.051, 0.496) 0.142 (0.041, 0.791)
-+++- graduation 0 6 401 0 4 3
-+++- futility 0 256 0 237 245 246
-+++- max_n 0 0 0 0 0 0
-+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- post_p NA (NA, NA) 0.47 (0.42, 0.51) NA (NA, NA) 0.46 (0.46, 0.46) 0.56 (0.56, 0.56) 0.49 (0.49, 0.49)
-+++- rate 0.116 (0, 1.344) 0.203 (0, 1.352) 0 (0, 0.235) 0.119 (0, 3.545) 0.115 (0.04, 1.431) 0.122 (0, 0.385)
-++++ graduation 0 6 432 0 4 2
-++++ futility 0 283 0 266 277 294
-++++ max_n 0 0 0 0 0 0
-++++ n 3 (1, 6) 1 (0, 4) 0 (0, 3) 2 (0, 4) 2 (0, 4) 1 (0, 4)
-++++ n_unique 3 (1, 6) 1 (0, 4) 0 (0, 2) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++++ post_p NA (NA, NA) 0.44 (0.31, 0.63) 0.61 (0.44, 0.79) 0.44 (0.31, 0.67) 0.43 (0.28, 0.6) 0.45 (0.31, 0.65)
-++++ rate 0.077 (0, 0.224) 0.135 (0.035, 0.487) 0.039 (0, 0.171) 0.129 (0.045, 0.46) 0.138 (0.05, 0.57) 0.13 (0.038, 0.457)
+—- graduation 0 3 225 0 2 1
+—- futility 0 37 0 17 23 26
+—- max_n 0 0 0 0 0 0
+—- n 5 (2, 8) 2 (1, 6) 3 (0, 6) 2 (0, 5) 2 (1, 5) 2 (1, 5)
+—- n_unique 4 (2, 8) 2 (0, 5) 2 (0, 6) 2 (0, 4) 2 (1, 4) 2 (0, 5)
+—- post_p NA (NA, NA) 0.42 (0.26, 0.63) 0.67 (0.43, 0.89) 0.41 (0.26, 0.62) 0.42 (0.26, 0.64) 0.45 (0.29, 0.65)
+—- rate 0.082 (0.034, 0.187) 0.131 (0.047, 0.412) 0.045 (0, 0.131) 0.131 (0.041, 0.452) 0.125 (0.048, 0.442) 0.112 (0.046, 0.391)
+—+ graduation 0 3 336 0 2 1
+—+ futility 0 146 0 119 130 177
+—+ max_n 0 0 0 0 0 0
+—+ n 2 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ n_unique 2 (0, 4) 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ post_p NA (NA, NA) 0.46 (0.33, 0.62) 0.59 (0.43, 0.78) 0.46 (0.35, 0.61) 0.45 (0.34, 0.63) 0.46 (0.35, 0.6)
+—+ rate 0.087 (0, 0.292) 0.139 (0.021, 0.516) 0.043 (0, 0.165) 0.129 (0.029, 0.627) 0.134 (0.029, 0.629) 0.138 (0.037, 0.522)
+–+- graduation 0 4 290 0 2 2
+–+- futility 0 99 0 78 75 101
+–+- max_n 0 0 0 0 0 0
+–+- n 8 (4, 12) 3 (1, 7) 4 (1, 9) 3 (1, 8) 3 (1, 7) 3 (1, 6)
+–+- n_unique 7 (4, 12) 3 (1, 7) 3 (1, 9) 3 (1, 7) 3 (1, 6) 3 (1, 6)
+–+- post_p NA (NA, NA) 0.38 (0.2, 0.68) 0.76 (0.46, 0.96) 0.39 (0.25, 0.64) 0.38 (0.21, 0.64) 0.39 (0.21, 0.65)
+–+- rate 0.082 (0.044, 0.149) 0.144 (0.053, 0.385) 0.041 (0.013, 0.108) 0.128 (0.063, 0.488) 0.138 (0.062, 0.446) 0.129 (0.055, 0.413)
+–++ graduation 0 4 368 0 2 2
+–++ futility 0 172 0 150 153 210
+–++ max_n 0 0 0 0 0 0
+–++ n 4 (1, 7) 2 (0, 5) 1 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 5)
+–++ n_unique 3 (1, 6) 2 (0, 4) 1 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 4)
+–++ post_p NA (NA, NA) 0.45 (0.28, 0.64) 0.65 (0.44, 0.85) 0.45 (0.28, 0.66) 0.42 (0.28, 0.66) 0.42 (0.28, 0.6)
+–++ rate 0.081 (0.027, 0.235) 0.127 (0.048, 0.425) 0.04 (0, 0.137) 0.126 (0.038, 0.403) 0.131 (0.043, 0.511) 0.144 (0.053, 0.565)
+-+– graduation 0 3 363 0 2 1
+-+– futility 0 202 0 161 170 183
+-+– max_n 0 0 0 0 0 0
+-+– n 1 (0, 3) 1 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– n_unique 1 (0, 3) 1 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– post_p NA (NA, NA) 0.47 (0.36, 0.62) 0.55 (0.42, 0.69) 0.47 (0.39, 0.6) 0.46 (0.37, 0.61) 0.46 (0.36, 0.6)
+-+– rate 0.086 (0, 0.354) 0.143 (0, 0.72) 0.043 (0, 0.279) 0.134 (0, 0.505) 0.141 (0, 0.67) 0.135 (0, 0.8)
+-+-+ graduation 0 3 408 0 2 1
+-+-+ futility 0 247 0 206 219 255
+-+-+ max_n 0 0 0 0 0 0
+-+-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ post_p NA (NA, NA) 0.47 (0.43, 0.5) 0.55 (0.55, 0.56) 0.52 (0.51, 0.52) 0.48 (0.43, 0.54) 0.56 (0.56, 0.56)
+-+-+ rate 0.104 (0, 1.417) 0.093 (0, 0.546) 0.039 (0, 0.119) 0.105 (0, 0.662) 0.109 (0, 0.782) 0.128 (0.03, 0.759)
+-++- graduation 0 4 389 0 2 2
+-++- futility 0 229 0 186 194 220
+-++- max_n 0 0 0 0 0 0
+-++- n 24 (17, 31) 6 (2, 18) 8 (3, 22) 7 (3, 18) 7 (3, 18) 6 (2, 18)
+-++- n_unique 22 (15, 29) 6 (2, 16) 8 (2, 20) 7 (3, 17) 6 (2, 17) 6 (2, 17)
+-++- post_p NA (NA, NA) 0.27 (0.1, 0.55) 0.92 (0.6, 1) 0.28 (0.1, 0.59) 0.29 (0.1, 0.58) 0.28 (0.12, 0.56)
+-++- rate 0.079 (0.054, 0.108) 0.133 (0.078, 0.33) 0.039 (0.02, 0.071) 0.128 (0.076, 0.275) 0.122 (0.076, 0.311) 0.134 (0.081, 0.316)
+-+++ graduation 0 4 421 0 2 2
+-+++ futility 0 263 0 223 233 276
+-+++ max_n 0 0 0 0 0 0
+-+++ n 18 (12, 24) 6 (2, 15) 4 (1, 13) 6 (2, 15) 6 (2, 15) 5 (2, 16)
+-+++ n_unique 16 (11, 22) 5 (1, 14) 4 (1, 12) 5 (2, 14) 5 (2, 14) 5 (2, 15)
+-+++ post_p NA (NA, NA) 0.33 (0.15, 0.61) 0.84 (0.48, 0.98) 0.29 (0.13, 0.61) 0.3 (0.13, 0.67) 0.3 (0.13, 0.64)
+-+++ rate 0.078 (0.05, 0.113) 0.127 (0.074, 0.302) 0.039 (0.015, 0.095) 0.131 (0.079, 0.321) 0.128 (0.077, 0.323) 0.127 (0.078, 0.281)
++— graduation 0 5 257 0 4 2
++— futility 0 88 0 108 121 86
++— max_n 0 0 0 0 0 0
++— n 8 (4, 13) 3 (1, 7) 3 (0, 8) 4 (2, 8) 4 (2, 8) 4 (1, 8)
++— n_unique 7 (4, 12) 3 (1, 6) 3 (0, 8) 4 (2, 8) 4 (2, 7) 3 (1, 7)
++— post_p NA (NA, NA) 0.4 (0.21, 0.69) 0.75 (0.44, 0.94) 0.37 (0.2, 0.67) 0.37 (0.18, 0.65) 0.38 (0.21, 0.65)
++— rate 0.077 (0.04, 0.147) 0.13 (0.06, 0.383) 0.04 (0, 0.125) 0.122 (0.061, 0.297) 0.125 (0.065, 0.372) 0.13 (0.065, 0.373)
++–+ graduation 0 5 358 0 4 1
++–+ futility 0 175 0 186 200 210
++–+ max_n 0 0 0 0 0 0
++–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ post_p NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) 0.48 (0.48, 0.48) 0.5 (0.46, 0.53) NA (NA, NA)
++–+ rate 0.121 (0, 1.239) 0.089 (0, 0.84) 0.056 (0, 0.24) 0.109 (0.013, 0.293) 0.238 (0, 0.826) 0.118 (0, 0.37)
++-+- graduation 0 6 313 0 4 3
++-+- futility 0 139 0 155 155 148
++-+- max_n 0 0 0 0 0 0
++-+- n 1 (0, 3) 0 (0, 2) 0 (0, 1) 1 (0, 2) 1 (0, 2) 0 (0, 2)
++-+- n_unique 1 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 2) 1 (0, 2) 0 (0, 2)
++-+- post_p NA (NA, NA) 0.47 (0.4, 0.57) 0.56 (0.46, 0.63) 0.47 (0.4, 0.59) 0.46 (0.38, 0.59) 0.47 (0.4, 0.57)
++-+- rate 0.079 (0, 0.585) 0.154 (0, 0.651) 0.025 (0, 0.158) 0.127 (0, 0.739) 0.139 (0.031, 0.784) 0.129 (0, 0.838)
++-++ graduation 0 6 385 0 4 2
++-++ futility 0 201 0 208 216 241
++-++ max_n 0 0 0 0 0 0
++-++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ post_p NA (NA, NA) NA (NA, NA) 0.49 (0.49, 0.49) 0.49 (0.43, 0.55) 0.5 (0.46, 0.55) 0.47 (0.47, 0.47)
++-++ rate 0.146 (0, 1.672) 0.099 (0, 0.204) 0.057 (0, 0.407) 0.187 (0, 2.527) 0.379 (0.052, 1.228) 0.035 (0, 0.188)
+++– graduation 0 5 377 0 4 2
+++– futility 0 234 0 219 228 215
+++– max_n 0 0 0 0 0 0
+++– n 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– n_unique 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– post_p NA (NA, NA) 0.52 (0.44, 0.57) 0.52 (0.43, 0.6) 0.46 (0.43, 0.55) 0.48 (0.42, 0.56) 0.49 (0.44, 0.57)
+++– rate 0.064 (0, 0.664) 0.149 (0, 0.578) 0.048 (0, 0.399) 0.186 (0, 0.973) 0.186 (0, 0.715) 0.109 (0, 0.359)
+++-+ graduation 0 5 420 0 4 1
+++-+ futility 0 267 0 255 266 273
+++-+ max_n 0 0 0 0 0 0
+++-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ post_p NA (NA, NA) 0.52 (0.52, 0.52) 0.47 (0.47, 0.47) 0.44 (0.41, 0.47) 0.55 (0.47, 0.57) 0.48 (0.47, 0.5)
+++-+ rate 0.075 (0, 0.529) 0.09 (0, 0.606) 0.085 (0.012, 0.308) 0.182 (0.041, 0.943) 0.121 (0.029, 1.358) 0.085 (0, 1.108)
++++- graduation 0 6 401 0 4 3
++++- futility 0 256 0 237 245 246
++++- max_n 0 0 0 0 0 0
++++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- post_p NA (NA, NA) 0.48 (0.46, 0.49) 0.54 (0.54, 0.54) 0.47 (0.47, 0.47) 0.54 (0.54, 0.54) NA (NA, NA)
++++- rate 0.063 (0, 0.498) 0.117 (0, 2.046) 0.019 (0, 0.599) 0.128 (0, 0.803) 0.061 (0, 0.491) 0.121 (0, 0.832)
+++++ graduation 0 6 432 0 4 2
+++++ futility 0 283 0 266 277 294
+++++ max_n 0 0 0 0 0 0
+++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ post_p NA (NA, NA) 0.48 (0.43, 0.5) 0.52 (0.45, 0.59) 0.52 (0.47, 0.57) 0.47 (0.42, 0.48) 0.55 (0.46, 0.57)
+++++ rate 0.08 (0, 0.373) 0.176 (0, 0.55) 0.061 (0, 0.888) 0.169 (0, 1.082) 0.185 (0, 0.836) 0.057 (0, 0.796)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4 TC5
all count 3 225 2 1
all time_stop 5 (5, 5) 10 (5, 28) 7 (6, 8) 5 (5, 5)
all n_trt 30 (28, 33) 55 (28, 144) 27 (25, 29) 33 (33, 33)
all n_control 52 (43, 54) 88 (49, 295) 62 (57, 68) 46 (46, 46)
all post_p 0.91 (0.88, 0.94) 1 (0.92, 1) 0.9 (0.9, 0.91) 0.86 (0.86, 0.86)
all order 1 (1, 1) 1 (1, 4) 1.5 (1.1, 1.9) 1 (1, 1)
AR- & TP53- count 4 325 2 4 2
AR- & TP53- time_stop 6 (5, 7) 11 (8, 25) 10 (10, 11) 14 (10, 15) 14 (12, 16)
AR- & TP53- n_trt 30 (26, 33) 35 (25, 115) 28 (26, 30) 36 (26, 52) 29 (27, 31)
AR- & TP53- n_control 42 (29, 54) 60 (38, 150) 58 (56, 60) 72 (52, 87) 82 (69, 94)
AR- & TP53- post_p 0.92 (0.89, 0.96) 0.98 (0.91, 1) 0.96 (0.94, 0.99) 0.96 (0.93, 0.99) 0.93 (0.92, 0.95)
AR- & TP53- order 1 (1, 1) 1 (1, 3) 2 (1.2, 2.8) 1.5 (1, 2) 2 (2, 2)
HRD+ count 2 40 2 1
HRD+ time_stop 20 (20, 21) 28 (21, 35) 20 (15, 26) 20 (20, 20)
HRD+ n_trt 28 (26, 29) 26 (25, 37) 25 (25, 25) 26 (26, 26)
HRD+ n_control 33 (33, 33) 45 (29, 62) 30 (17, 43) 25 (25, 25)
HRD+ post_p 0.89 (0.87, 0.92) 0.99 (0.95, 1) 0.9 (0.86, 0.94) 0.93 (0.93, 0.93)
HRD+ order 4 (3.2, 4.8) 2 (1, 5) 4 (2.4, 5.6) 2 (2, 2)
TP53+ count 219
TP53+ time_stop 18 (12, 29)
TP53+ n_trt 37 (26, 70)
TP53+ n_control 52 (33, 98)
TP53+ post_p 1 (0.96, 1)
TP53+ order 2 (1, 4)
TEfus+ count 1 146 1
TEfus+ time_stop 21 (21, 21) 19 (12, 31) 12 (12, 12)
TEfus+ n_trt 28 (28, 28) 34 (25, 58) 26 (26, 26)
TEfus+ n_control 59 (59, 59) 53 (31, 108) 31 (31, 31)
TEfus+ post_p 0.98 (0.98, 0.98) 1 (0.98, 1) 0.87 (0.87, 0.87)
TEfus+ order 1 (1, 1) 3 (1, 5) 1 (1, 1)
PI3K+ count 173
PI3K+ time_stop 20 (14, 31)
PI3K+ n_trt 31 (25, 57)
PI3K+ n_control 59 (36, 107)
PI3K+ post_p 1 (0.97, 1)
PI3K+ order 2 (1, 4)
Futility:
signature var TC1 TC3 TC4 TC5
all count 37 17 23 26
all time_stop 16 (3, 31) 28 (11, 35) 26 (9, 35) 24 (10, 34)
all n_trt 72 (27, 112) 85 (47, 119) 78 (33, 129) 70 (39, 124)
all n_control 152 (34, 331) 290 (78, 412) 269 (87, 405) 250 (82, 387)
all post_p 0 (0, 0.18) 0 (0, 0.06) 0 (0, 0.01) 0 (0, 0.02)
all order 3 (1, 7) 5 (1, 9) 4 (1, 8) 6 (1, 8.5)
AR- & TP53- count 250 232 213 245
AR- & TP53- time_stop 18 (7, 32) 22 (12, 33) 21 (12, 33) 23 (13, 32)
AR- & TP53- n_trt 45 (26, 93) 50 (27, 102) 43 (26, 111) 43 (26, 112)
AR- & TP53- n_control 104 (37, 213) 134 (65, 219) 125 (64, 219) 140 (68, 219)
AR- & TP53- post_p 0.03 (0, 0.19) 0.01 (0, 0.12) 0.03 (0, 0.11) 0.02 (0, 0.13)
AR- & TP53- order 2 (1, 6) 3 (1, 6) 3 (1, 6) 3 (1, 6)
HRD+ count 53 96 102 62
HRD+ time_stop 32 (24, 35) 27 (20, 35) 30 (22, 34) 31 (25, 36)
HRD+ n_trt 28 (25, 40) 28 (25, 38) 29 (25, 40) 28 (25, 40)
HRD+ n_control 54 (36, 66) 41 (26, 62) 47 (31, 64) 50 (35, 65)
HRD+ post_p 0.05 (0.01, 0.22) 0.07 (0.01, 0.19) 0.06 (0.01, 0.2) 0.07 (0.01, 0.19)
HRD+ order 6 (3, 8) 4 (1, 8) 5 (2, 8.9) 6 (3, 9)
TP53+ count 182 156 165 177
TP53+ time_stop 24 (15, 34) 24 (16, 32) 25 (16, 34) 23 (13, 34)
TP53+ n_trt 38 (25, 62) 34 (26, 53) 37 (26, 63) 33 (25, 59)
TP53+ n_control 78 (44, 124) 78 (47, 117) 84 (46, 124) 76 (34, 129)
TP53+ post_p 0.03 (0, 0.11) 0.03 (0, 0.12) 0.03 (0, 0.1) 0.03 (0, 0.12)
TP53+ order 3 (1, 7) 3 (1, 6.5) 3 (1, 7.6) 3 (1, 7)
TEfus+ count 78 72 69 92
TEfus+ time_stop 27 (17, 35) 26 (17, 34) 26 (16, 35) 24 (17, 35)
TEfus+ n_trt 36 (26, 49) 33 (25, 50) 34 (26, 53) 34 (25, 53)
TEfus+ n_control 87 (46, 122) 84 (49, 121) 80 (44, 125) 75 (43, 124)
TEfus+ post_p 0.01 (0, 0.06) 0.01 (0, 0.1) 0.02 (0, 0.07) 0.01 (0, 0.11)
TEfus+ order 5 (2, 8) 5 (2, 8) 5 (2, 8) 5 (2, 8.9)
PI3K+ count 125 113 122 172
PI3K+ time_stop 25 (16, 35) 26 (17, 34) 25 (17, 35) 19 (10, 33)
PI3K+ n_trt 36 (26, 66) 36 (26, 53) 36 (26, 61) 34 (26, 58)
PI3K+ n_control 79 (48, 121) 86 (48, 127) 80 (51, 125) 57 (23, 118)
PI3K+ post_p 0.02 (0, 0.09) 0.02 (0, 0.09) 0.02 (0, 0.07) 0.03 (0, 0.18)
PI3K+ order 5 (2, 8) 4 (2, 8) 5 (2, 8) 3 (1, 6.9)


By subgroup combinations

Graduation:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC1 time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
all TC1 n 17 (13, 19) 2 (0, 3) 0 (0, 2) 2 (0, 2) 3 (1, 4) 2 (0, 3) 0 (0, 0) 1 (1, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 0) 2 (0, 3) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.7 (0.69, 0.75) 0.55 (0.55, 0.55) NA (NA, NA) 0.54 (0.52, 0.57) 0.54 (0.54, 0.55) 0.54 (0.53, 0.55) NA (NA, NA) 0.52 (0.51, 0.53) 0.53 (0.53, 0.53) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.58 (0.58, 0.58) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.034 (0.032, 0.039) 0.073 (0.015, 0.131) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225 225
all TC2 time 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28) 10 (5, 28)
all TC2 n 18 (9, 56) 3 (0, 9) 1 (0, 2) 1 (0, 4) 4 (1, 12) 3 (1, 11) 2 (0, 5) 3 (0, 9) 2 (0, 10) 0 (0, 0) 1 (0, 4) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 1 (0, 4) 0 (0, 2) 2 (0, 5) 1 (0, 3) 0 (0, 1) 0 (0, 0) 5 (2, 14) 3 (1, 8) 1 (0, 5) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.9 (0.61, 1) 0.62 (0.52, 0.92) 0.55 (0.52, 0.68) 0.57 (0.52, 0.83) 0.64 (0.52, 0.94) 0.59 (0.52, 0.91) 0.57 (0.52, 0.78) 0.61 (0.52, 0.93) 0.62 (0.53, 0.91) NA (NA, NA) 0.61 (0.52, 0.82) 0.57 (0.52, 0.73) 0.52 (0.52, 0.52) 0.58 (0.51, 0.68) NA (NA, NA) 0.58 (0.51, 0.75) 0.55 (0.51, 0.73) 0.55 (0.51, 0.6) 0.57 (0.51, 0.8) 0.58 (0.52, 0.75) 0.54 (0.51, 0.6) 0.53 (0.53, 0.53) 0.61 (0.52, 0.96) 0.61 (0.51, 0.88) 0.6 (0.52, 0.85) NA (NA, NA) 0.54 (0.52, 0.64) 0.5 (0.5, 0.5) 0.54 (0.52, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.033 (0, 0.06) 0 (0, 0.066) 0 (0, 0.109) 0 (0, 0.071) 0 (0, 0.08) 0.016 (0, 0.076) 0 (0, 0.084) 0 (0, 0.077) 0 (0, 0.068) 0 (0, 0) 0 (0, 0.08) 0 (0, 0.08) 0 (0, 0.056) 0 (0, 0.063) 0.053 (0.011, 0.095) 0 (0, 0.073) 0 (0, 0.093) 0 (0, 0.098) 0 (0, 0.075) 0 (0, 0.138) 0 (0, 0.258) 0 (0, 0.034) 0.018 (0, 0.065) 0 (0, 0.077) 0 (0, 0.068) 0 (0, 0) 0 (0, 0.118) 0 (0, 0.08) 0 (0, 0.541) 0.203 (0.041, 0.366) 0 (0, 0) 0.342 (0.08, 1.138)
all TC4 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC4 time 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8) 7 (6, 8)
all TC4 n 3 (1, 5) 2 (1, 3) 0 (0, 0) 2 (1, 3) 2 (1, 3) 0 (0, 1) 0 (0, 1) 0 (0, 1) 7 (7, 7) 0 (0, 0) 4 (3, 4) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 2 (1, 3) 1 (0, 2) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.63 (0.63, 0.63) 0.58 (0.54, 0.61) NA (NA, NA) 0.56 (0.53, 0.59) 0.61 (0.59, 0.62) 0.57 (0.57, 0.57) 0.61 (0.61, 0.61) 0.51 (0.51, 0.51) 0.57 (0.52, 0.61) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) 0.53 (0.51, 0.54) 0.51 (0.51, 0.51) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.09 (0.059, 0.121) NA (NA, NA) 0.028 (0.006, 0.05) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.03 (0.006, 0.054) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC5 time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
all TC5 n 1 (1, 1) 9 (9, 9) 1 (1, 1) 1 (1, 1) 0 (0, 0) 7 (7, 7) 0 (0, 0) 3 (3, 3) 1 (1, 1) 0 (0, 0) 1 (1, 1) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 4 (4, 4) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.55 (0.55, 0.55) 0.56 (0.56, 0.56) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) 0.62 (0.62, 0.62) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0 (0, 0) 0 (0, 0) 5.392 (5.392, 5.392) 0 (0, 0) NA (NA, NA) 0.039 (0.039, 0.039) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 4 4 4 4 4 4 4 4
AR- & TP53- TC1 time 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7)
AR- & TP53- TC1 n 22 (19, 27) 3 (1, 4) 2 (2, 2) 1 (0, 2) 2 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0)
AR- & TP53- TC1 post_p 0.81 (0.79, 0.89) 0.69 (0.59, 0.71) 0.52 (0.52, 0.52) 0.53 (0.51, 0.55) 0.57 (0.53, 0.59) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.044 (0.039, 0.051) 0 (0, 0.065) 0 (0, 0.158) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA)
AR- & TP53- TC2 count 325 325 325 325 325 325 325 325
AR- & TP53- TC2 time 11 (8, 25) 11 (8, 25) 11 (8, 25) 11 (8, 25) 11 (8, 25) 11 (8, 25) 11 (8, 25) 11 (8, 25)
AR- & TP53- TC2 n 24 (17, 80) 4 (1, 12) 1 (0, 3) 2 (0, 5) 3 (1, 11) 0 (0, 0) 2 (0, 5) 0 (0, 2)
AR- & TP53- TC2 post_p 0.94 (0.77, 1) 0.64 (0.52, 0.9) 0.55 (0.51, 0.7) 0.58 (0.52, 0.8) 0.63 (0.52, 0.91) 0.61 (0.61, 0.61) 0.57 (0.52, 0.78) 0.55 (0.51, 0.71)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.035 (0.014, 0.054) 0 (0, 0.073) 0 (0, 0.118) 0 (0, 0.084) 0 (0, 0.083) 0 (0, 0) 0 (0, 0.081) 0 (0, 0.096)
AR- & TP53- TC3 count 2 2 2 2 2 2 2 2
AR- & TP53- TC3 time 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11)
AR- & TP53- TC3 n 16 (15, 17) 4 (2, 6) 0 (0, 1) 2 (1, 2) 2 (1, 2) 0 (0, 0) 3 (1, 5) 2 (0, 3)
AR- & TP53- TC3 post_p 0.88 (0.86, 0.89) 0.73 (0.58, 0.88) 0.53 (0.53, 0.53) 0.6 (0.53, 0.67) 0.6 (0.54, 0.67) NA (NA, NA) 0.51 (0.51, 0.51) NA (NA, NA)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.021 (0.021, 0.021) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.052 (0.01, 0.093) 0.07 (0.07, 0.07)
AR- & TP53- TC4 count 4 4 4 4 4 4 4 4
AR- & TP53- TC4 time 14 (10, 15) 14 (10, 15) 14 (10, 15) 14 (10, 15) 14 (10, 15) 14 (10, 15) 14 (10, 15) 14 (10, 15)
AR- & TP53- TC4 n 16 (14, 28) 4 (2, 5) 0 (0, 0) 3 (1, 6) 6 (5, 12) 0 (0, 0) 4 (1, 6) 0 (0, 2)
AR- & TP53- TC4 post_p 0.84 (0.78, 0.92) 0.56 (0.5, 0.7) NA (NA, NA) 0.62 (0.55, 0.7) 0.64 (0.55, 0.8) NA (NA, NA) 0.58 (0.53, 0.67) 0.5 (0.5, 0.5)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.042 (0.033, 0.051) 0.032 (0, 0.094) NA (NA, NA) 0.041 (0.008, 0.062) 0.064 (0.015, 0.08) NA (NA, NA) 0.05 (0.038, 0.075) 0.09 (0.09, 0.09)
AR- & TP53- TC5 count 2 2 2 2 2 2 2 2
AR- & TP53- TC5 time 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16) 14 (12, 16)
AR- & TP53- TC5 n 13 (11, 15) 6 (4, 8) 0 (0, 1) 2 (1, 4) 6 (5, 6) 0 (0, 0) 2 (1, 2) 0 (0, 0)
AR- & TP53- TC5 post_p 0.74 (0.73, 0.74) 0.63 (0.53, 0.73) NA (NA, NA) 0.61 (0.6, 0.62) 0.73 (0.72, 0.73) NA (NA, NA) 0.55 (0.52, 0.57) NA (NA, NA)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.049 (0.039, 0.058) 0.096 (0.091, 0.101) 0 (0, 0) 0.016 (0.003, 0.029) 0.011 (0.002, 0.02) NA (NA, NA) 0 (0, 0) NA (NA, NA)
HRD+ TC1 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
HRD+ TC1 time 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21)
HRD+ TC1 n 14 (12, 16) 0 (0, 0) 4 (4, 5) 2 (0, 3) 0 (0, 0) 2 (1, 2) 0 (0, 0) 1 (0, 2) 4 (3, 5) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.73 (0.72, 0.74) NA (NA, NA) 0.71 (0.6, 0.82) 0.53 (0.53, 0.53) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) 0.59 (0.59, 0.59) 0.62 (0.58, 0.66) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.056 (0.053, 0.06) NA (NA, NA) 0.03 (0.006, 0.054) 0.117 (0.117, 0.117) NA (NA, NA) 1.114 (0.273, 1.956) NA (NA, NA) 0.048 (0.048, 0.048) 0.075 (0.071, 0.079) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.274 (0.274, 0.274) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 40 40 40 40 40 40 40 40 40 40 40 40 40 40 40 40
HRD+ TC2 time 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35) 28 (21, 35)
HRD+ TC2 n 14 (8, 20) 0 (0, 0) 5 (1, 9) 2 (0, 4) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 5 (3, 9) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.93 (0.77, 0.99) NA (NA, NA) 0.78 (0.57, 0.86) 0.65 (0.53, 0.86) NA (NA, NA) 0.65 (0.52, 0.81) NA (NA, NA) 0.59 (0.51, 0.82) 0.76 (0.58, 0.9) NA (NA, NA) 0.56 (0.53, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.034 (0.02, 0.053) NA (NA, NA) 0.038 (0, 0.071) 0.014 (0, 0.106) 0.044 (0.044, 0.044) 0.016 (0, 0.063) NA (NA, NA) 0 (0, 0.132) 0.034 (0, 0.061) 1.042 (0.367, 1.717) 0 (0, 0.129) 0 (0, 0) 1.004 (0.394, 1.613) 0 (0, 0) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
HRD+ TC4 time 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26) 20 (15, 26)
HRD+ TC4 n 11 (11, 11) 0 (0, 0) 5 (5, 5) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (1, 2) 7 (6, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.77 (0.73, 0.81) NA (NA, NA) 0.56 (0.52, 0.6) 0.59 (0.59, 0.59) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.55) 0.77 (0.77, 0.77) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.051 (0.05, 0.051) NA (NA, NA) 0.093 (0.067, 0.119) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.031 (0.006, 0.056) 0.063 (0.061, 0.065) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
HRD+ TC5 time 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20)
HRD+ TC5 n 14 (14, 14) 0 (0, 0) 2 (2, 2) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 3 (3, 3) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1)
HRD+ TC5 post_p 0.96 (0.96, 0.96) NA (NA, NA) 0.52 (0.52, 0.52) 0.66 (0.66, 0.66) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.68 (0.68, 0.68) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.062 (0.062, 0.062) NA (NA, NA) 0.111 (0.111, 0.111) 0.084 (0.084, 0.084) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.075 (0.075, 0.075) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TP53+ TC2 count 219 219 219 219 219 219 219 219 219 219 219 219 219 219 219 219
TP53+ TC2 time 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29)
TP53+ TC2 n 8 (4, 18) 6 (3, 14) 3 (1, 6) 5 (2, 12) 0 (0, 0) 0 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 9 (4, 16) 5 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.79 (0.56, 0.98) 0.75 (0.58, 0.95) 0.6 (0.51, 0.8) 0.75 (0.54, 0.92) NA (NA, NA) 0.57 (0.52, 0.7) NA (NA, NA) 0.57 (0.52, 0.74) 0.54 (0.51, 0.61) 0.56 (0.54, 0.58) 0.81 (0.64, 0.96) 0.73 (0.54, 0.91) 0.54 (0.53, 0.58) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.034 (0, 0.077) 0.034 (0, 0.071) 0.027 (0, 0.08) 0.034 (0, 0.076) 0.035 (0, 0.191) 0 (0, 0.108) 0.106 (0.021, 0.363) 0 (0, 0.08) 0 (0, 0.22) 0.039 (0, 0.131) 0.033 (0, 0.063) 0.03 (0, 0.077) 0 (0, 0.967) 0 (0, 0) 0 (0, 0) 0 (0, 0.829)
TEfus+ TC1 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC1 time 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21)
TEfus+ TC1 n 0 (0, 0) 3 (3, 3) 3 (3, 3) 4 (4, 4) 3 (3, 3) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 10 (10, 10) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p NA (NA, NA) 0.65 (0.65, 0.65) 0.57 (0.57, 0.57) 0.92 (0.92, 0.92) 0.66 (0.66, 0.66) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.82 (0.82, 0.82) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate NA (NA, NA) 0.06 (0.06, 0.06) 0.074 (0.074, 0.074) 0 (0, 0) 0.044 (0.044, 0.044) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.044 (0.044, 0.044) 0.052 (0.052, 0.052) 0.095 (0.095, 0.095) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 146 146 146 146 146 146 146 146 146 146 146 146 146 146 146 146
TEfus+ TC2 time 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31) 19 (12, 31)
TEfus+ TC2 n 1 (0, 3) 2 (0, 6) 3 (0, 6) 5 (2, 13) 2 (0, 5) 0 (0, 2) 0 (0, 0) 1 (0, 2) 4 (1, 8) 2 (0, 4) 9 (4, 17) 5 (2, 9) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.58 (0.52, 0.8) 0.67 (0.53, 0.88) 0.62 (0.52, 0.88) 0.77 (0.58, 0.95) 0.64 (0.52, 0.82) 0.59 (0.54, 0.71) NA (NA, NA) 0.58 (0.52, 0.73) 0.67 (0.52, 0.9) 0.6 (0.52, 0.73) 0.83 (0.63, 0.97) 0.75 (0.54, 0.94) 0.55 (0.52, 0.6) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0 (0, 0.107) 0.027 (0, 0.081) 0.028 (0, 0.079) 0.029 (0, 0.066) 0.021 (0, 0.084) 0 (0, 0.097) 0.053 (0.011, 0.095) 0 (0, 0.085) 0.036 (0, 0.091) 0.027 (0, 0.088) 0.031 (0, 0.065) 0.031 (0, 0.078) 0 (0, 0.166) 0.057 (0, 0.317) 0 (0, 0) 0.342 (0.123, 1.138)
TEfus+ TC5 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC5 time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
TEfus+ TC5 n 1 (1, 1) 5 (5, 5) 1 (1, 1) 2 (2, 2) 1 (1, 1) 0 (0, 0) 0 (0, 0) 2 (2, 2) 2 (2, 2) 0 (0, 0) 8 (8, 8) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.52 (0.52, 0.52) 0.58 (0.58, 0.58) NA (NA, NA) 0.51 (0.51, 0.51) 0.63 (0.63, 0.63) NA (NA, NA) NA (NA, NA) 0.56 (0.56, 0.56) 0.56 (0.56, 0.56) NA (NA, NA) 0.74 (0.74, 0.74) 0.57 (0.57, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0 (0, 0) 0.049 (0.049, 0.049) 0 (0, 0) 0.066 (0.066, 0.066) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.114 (0.114, 0.114) 0.046 (0.046, 0.046) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 173 173 173 173 173 173 173 173 173 173 173 173 173 173 173 173
PI3K+ TC2 time 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31) 20 (14, 31)
PI3K+ TC2 n 6 (2, 15) 2 (0, 6) 8 (3, 15) 6 (2, 13) 0 (0, 0) 1 (0, 3) 0 (0, 2) 1 (0, 2) 1 (0, 3) 2 (0, 4) 0 (0, 0) 5 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.8 (0.57, 0.97) 0.68 (0.52, 0.86) 0.79 (0.59, 0.96) 0.77 (0.54, 0.95) NA (NA, NA) 0.59 (0.52, 0.81) 0.57 (0.52, 0.73) 0.57 (0.51, 0.76) 0.56 (0.52, 0.7) 0.6 (0.52, 0.74) 0.53 (0.53, 0.53) 0.75 (0.56, 0.95) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.032 (0, 0.069) 0.031 (0, 0.079) 0.034 (0, 0.072) 0.035 (0, 0.077) 0 (0, 0) 0 (0, 0.099) 0 (0, 0.112) 0 (0, 0.09) 0 (0, 0.12) 0.024 (0, 0.096) 0.048 (0, 0.101) 0.029 (0, 0.076) 0.199 (0, 1.227) 0.114 (0, 0.406) 0 (0, 0) 0.061 (0, 0.829)
Futility:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37 37
all TC1 time 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31) 16 (3, 31)
all TC1 n 19 (13, 30) 4 (1, 13) 1 (0, 3) 2 (0, 4) 5 (3, 12) 3 (0, 10) 1 (0, 4) 3 (0, 9) 1 (0, 8) 0 (0, 0) 0 (0, 5) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 1 (0, 3) 0 (0, 1) 1 (0, 3) 1 (0, 3) 0 (0, 2) 0 (0, 0) 3 (0, 7) 2 (0, 6) 0 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.23 (0.03, 0.41) 0.33 (0.14, 0.48) 0.43 (0.33, 0.48) 0.4 (0.21, 0.48) 0.4 (0.22, 0.48) 0.29 (0.17, 0.46) 0.42 (0.29, 0.49) 0.34 (0.15, 0.47) 0.32 (0.2, 0.45) NA (NA, NA) 0.38 (0.25, 0.49) 0.39 (0.25, 0.47) NA (NA, NA) 0.46 (0.33, 0.48) NA (NA, NA) 0.43 (0.34, 0.45) 0.4 (0.25, 0.47) 0.44 (0.38, 0.49) 0.39 (0.28, 0.46) 0.39 (0.31, 0.44) 0.46 (0.4, 0.47) NA (NA, NA) 0.34 (0.15, 0.45) 0.35 (0.21, 0.48) 0.39 (0.22, 0.48) NA (NA, NA) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.124 (0.085, 0.167) 0.162 (0.065, 0.675) 0.205 (0.015, 0.708) 0.272 (0.054, 1.267) 0.113 (0.026, 0.3) 0.161 (0.049, 0.439) 0.153 (0, 0.589) 0.165 (0.09, 0.546) 0.135 (0.103, 0.389) NA (NA, NA) 0.136 (0.074, 0.307) 0.22 (0.119, 1.606) NA (NA, NA) 0.24 (0.082, 2.269) 0.107 (0.107, 0.107) 0.119 (0, 1.307) 0.219 (0.05, 0.361) 0.178 (0, 0.321) 0.255 (0.11, 1.793) 0.181 (0, 0.769) 0.181 (0, 0.385) NA (NA, NA) 0.14 (0, 0.363) 0.128 (0, 0.502) 0.151 (0.037, 0.335) 0.041 (0.008, 0.074) 0.4 (0.215, 1.503) 0.091 (0.091, 0.091) 0.198 (0.198, 0.198) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17
all TC3 time 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35) 28 (11, 35)
all TC3 n 14 (8, 43) 6 (3, 15) 0 (0, 3) 2 (1, 4) 5 (3, 7) 4 (2, 11) 2 (0, 5) 3 (1, 7) 4 (2, 12) 0 (0, 0) 4 (2, 6) 1 (0, 2) 0 (0, 0) 2 (0, 2) 0 (0, 0) 0 (0, 3) 2 (0, 4) 0 (0, 1) 3 (0, 5) 0 (0, 2) 0 (0, 1) 0 (0, 0) 3 (1, 8) 5 (1, 8) 4 (1, 6) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.15 (0.03, 0.41) 0.32 (0.1, 0.47) 0.4 (0.36, 0.48) 0.35 (0.2, 0.46) 0.31 (0.13, 0.44) 0.28 (0.18, 0.47) 0.35 (0.21, 0.44) 0.34 (0.19, 0.49) 0.29 (0.15, 0.44) NA (NA, NA) 0.34 (0.18, 0.44) 0.4 (0.28, 0.49) NA (NA, NA) 0.42 (0.32, 0.49) NA (NA, NA) 0.45 (0.36, 0.49) 0.34 (0.32, 0.44) 0.42 (0.32, 0.46) 0.4 (0.25, 0.47) 0.41 (0.32, 0.47) 0.47 (0.46, 0.47) NA (NA, NA) 0.34 (0.24, 0.42) 0.33 (0.17, 0.49) 0.39 (0.25, 0.45) NA (NA, NA) 0.45 (0.42, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.118 (0.087, 0.156) 0.121 (0.09, 0.195) 0.135 (0.062, 0.222) 0.199 (0.072, 0.444) 0.158 (0.091, 0.312) 0.15 (0.107, 0.268) 0.215 (0.122, 0.465) 0.129 (0.065, 0.296) 0.141 (0.114, 0.423) 0.202 (0.202, 0.202) 0.141 (0.084, 0.265) 0.17 (0.057, 0.483) 0.137 (0.113, 0.161) 0.181 (0.069, 0.71) 0 (0, 0) 0.267 (0.074, 0.905) 0.158 (0.111, 0.297) 0.322 (0.164, 0.836) 0.107 (0.069, 0.242) 0.19 (0.138, 1.978) 0.167 (0.033, 0.221) NA (NA, NA) 0.166 (0.097, 0.762) 0.149 (0.075, 0.634) 0.139 (0.07, 0.431) NA (NA, NA) 0.201 (0.089, 0.692) NA (NA, NA) NA (NA, NA) 0.236 (0.145, 0.327) NA (NA, NA) NA (NA, NA)
all TC4 count 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23
all TC4 time 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35) 26 (9, 35)
all TC4 n 15 (4, 50) 6 (1, 12) 0 (0, 4) 3 (0, 7) 5 (3, 12) 5 (3, 11) 2 (0, 4) 3 (1, 6) 7 (3, 14) 0 (0, 0) 4 (2, 6) 2 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 0) 0 (0, 3) 1 (0, 5) 0 (0, 2) 2 (0, 6) 1 (0, 2) 0 (0, 1) 0 (0, 0) 4 (2, 12) 4 (2, 6) 3 (1, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.18 (0.03, 0.35) 0.33 (0.12, 0.41) 0.43 (0.36, 0.47) 0.38 (0.25, 0.47) 0.31 (0.12, 0.48) 0.24 (0.14, 0.44) 0.38 (0.25, 0.45) 0.33 (0.2, 0.48) 0.3 (0.1, 0.42) NA (NA, NA) 0.38 (0.23, 0.49) 0.38 (0.3, 0.49) NA (NA, NA) 0.39 (0.27, 0.49) NA (NA, NA) 0.44 (0.36, 0.47) 0.42 (0.24, 0.48) 0.47 (0.43, 0.48) 0.38 (0.25, 0.46) 0.42 (0.34, 0.49) 0.43 (0.34, 0.47) NA (NA, NA) 0.38 (0.17, 0.47) 0.34 (0.18, 0.47) 0.42 (0.28, 0.46) NA (NA, NA) 0.48 (0.44, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.139 (0.086, 0.353) 0.12 (0.097, 0.539) 0.16 (0.101, 0.354) 0.14 (0.098, 0.322) 0.132 (0.096, 0.259) 0.172 (0.096, 0.329) 0.156 (0.095, 0.348) 0.152 (0.089, 0.562) 0.16 (0.084, 0.323) NA (NA, NA) 0.163 (0.091, 0.31) 0.2 (0.055, 0.306) 0.213 (0.213, 0.213) 0.149 (0.042, 0.372) NA (NA, NA) 0.174 (0.07, 0.734) 0.156 (0.071, 0.412) 0.19 (0.118, 0.331) 0.176 (0.062, 0.635) 0.222 (0.081, 1.215) 0.222 (0.086, 0.455) 0 (0, 0) 0.143 (0.096, 0.371) 0.141 (0.093, 0.252) 0.161 (0.089, 0.855) NA (NA, NA) 0.156 (0.067, 0.185) 0.087 (0.087, 0.087) 0.088 (0.088, 0.088) 4.218 (4.218, 4.218) 0.112 (0.112, 0.112) NA (NA, NA)
all TC5 count 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26
all TC5 time 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34) 24 (10, 34)
all TC5 n 10 (6, 54) 8 (6, 14) 1 (0, 2) 4 (2, 6) 4 (2, 14) 6 (4, 11) 2 (0, 3) 6 (2, 8) 5 (0, 8) 0 (0, 0) 2 (0, 6) 0 (0, 3) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 1 (0, 3) 0 (0, 1) 2 (0, 4) 1 (0, 2) 0 (0, 2) 0 (0, 0) 3 (0, 6) 4 (2, 8) 2 (0, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.11 (0.03, 0.39) 0.28 (0.1, 0.46) 0.44 (0.38, 0.48) 0.32 (0.18, 0.48) 0.33 (0.2, 0.41) 0.32 (0.11, 0.45) 0.4 (0.2, 0.47) 0.34 (0.19, 0.45) 0.36 (0.09, 0.47) NA (NA, NA) 0.32 (0.24, 0.43) 0.47 (0.44, 0.49) NA (NA, NA) 0.44 (0.3, 0.49) NA (NA, NA) 0.41 (0.33, 0.47) 0.42 (0.35, 0.47) 0.45 (0.4, 0.48) 0.38 (0.29, 0.45) 0.42 (0.36, 0.49) 0.48 (0.41, 0.49) NA (NA, NA) 0.3 (0.16, 0.42) 0.25 (0.12, 0.43) 0.35 (0.23, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.142 (0.093, 0.286) 0.135 (0.088, 0.24) 0.237 (0.1, 0.744) 0.156 (0.094, 0.424) 0.14 (0.1, 0.326) 0.144 (0.081, 0.264) 0.152 (0.091, 0.293) 0.123 (0.087, 0.518) 0.141 (0.096, 0.317) NA (NA, NA) 0.228 (0.098, 0.696) 0.12 (0.047, 0.258) NA (NA, NA) 0.216 (0, 0.696) 0.122 (0.122, 0.122) 0.199 (0.079, 1.024) 0.126 (0.091, 0.547) 0.242 (0.089, 0.676) 0.229 (0.092, 0.565) 0.22 (0.061, 1.261) 0.224 (0.004, 0.788) 0 (0, 0) 0.165 (0.117, 0.535) 0.162 (0.087, 0.367) 0.159 (0.091, 0.961) NA (NA, NA) 0 (0, 0.108) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 250 250 250 250 250 250 250 250
AR- & TP53- TC1 time 18 (7, 32) 18 (7, 32) 18 (7, 32) 18 (7, 32) 18 (7, 32) 18 (7, 32) 18 (7, 32) 18 (7, 32)
AR- & TP53- TC1 n 22 (15, 53) 6 (2, 15) 2 (0, 4) 3 (1, 8) 4 (0, 15) 0 (0, 0) 3 (0, 7) 1 (0, 3)
AR- & TP53- TC1 post_p 0.13 (0.01, 0.39) 0.36 (0.13, 0.48) 0.43 (0.32, 0.49) 0.4 (0.21, 0.48) 0.37 (0.17, 0.48) 0.47 (0.44, 0.49) 0.41 (0.24, 0.49) 0.43 (0.28, 0.49)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.119 (0.092, 0.156) 0.136 (0.082, 0.305) 0.147 (0, 0.485) 0.145 (0.075, 0.467) 0.141 (0.087, 0.389) 10.787 (0.469, 75.756) 0.144 (0.076, 0.456) 0.166 (0, 0.579)
AR- & TP53- TC3 count 232 232 232 232 232 232 232 232
AR- & TP53- TC3 time 22 (12, 33) 22 (12, 33) 22 (12, 33) 22 (12, 33) 22 (12, 33) 22 (12, 33) 22 (12, 33) 22 (12, 33)
AR- & TP53- TC3 n 19 (8, 63) 7 (3, 17) 2 (0, 4) 3 (1, 9) 7 (4, 16) 0 (0, 0) 4 (1, 9) 2 (0, 4)
AR- & TP53- TC3 post_p 0.16 (0.03, 0.43) 0.32 (0.12, 0.47) 0.44 (0.31, 0.49) 0.39 (0.23, 0.48) 0.31 (0.12, 0.46) NA (NA, NA) 0.36 (0.16, 0.48) 0.42 (0.27, 0.48)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.116 (0.092, 0.171) 0.133 (0.09, 0.35) 0.146 (0.063, 0.462) 0.154 (0.093, 0.447) 0.131 (0.089, 0.28) 0 (0, 0.244) 0.156 (0.09, 0.489) 0.176 (0.08, 0.505)
AR- & TP53- TC4 count 213 213 213 213 213 213 213 213
AR- & TP53- TC4 time 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33) 21 (12, 33)
AR- & TP53- TC4 n 17 (7, 68) 6 (2, 21) 1 (0, 4) 3 (1, 8) 7 (4, 16) 0 (0, 0) 4 (2, 7) 2 (0, 4)
AR- & TP53- TC4 post_p 0.2 (0.02, 0.44) 0.34 (0.12, 0.47) 0.42 (0.29, 0.49) 0.4 (0.23, 0.49) 0.33 (0.1, 0.47) NA (NA, NA) 0.38 (0.21, 0.49) 0.43 (0.31, 0.49)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.122 (0.093, 0.204) 0.131 (0.088, 0.382) 0.168 (0.059, 0.645) 0.142 (0.08, 0.459) 0.127 (0.083, 0.253) 0.079 (0, 0.279) 0.148 (0.083, 0.415) 0.154 (0.07, 0.686)
AR- & TP53- TC5 count 245 245 245 245 245 245 245 245
AR- & TP53- TC5 time 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32)
AR- & TP53- TC5 n 16 (7, 71) 8 (4, 16) 1 (0, 4) 4 (2, 9) 6 (2, 17) 0 (0, 0) 3 (1, 8) 1 (0, 4)
AR- & TP53- TC5 post_p 0.16 (0.02, 0.43) 0.28 (0.11, 0.47) 0.43 (0.32, 0.48) 0.36 (0.19, 0.49) 0.34 (0.13, 0.47) 0.47 (0.47, 0.47) 0.39 (0.22, 0.48) 0.43 (0.3, 0.49)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.125 (0.092, 0.244) 0.125 (0.091, 0.246) 0.17 (0.076, 0.692) 0.143 (0.086, 0.386) 0.138 (0.093, 0.336) 1.355 (0.621, 2.089) 0.163 (0.089, 0.589) 0.151 (0.067, 0.578)
HRD+ TC1 count 53 53 53 53 53 53 53 53 53 53 53 53 53 53 53 53
HRD+ TC1 time 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35) 32 (24, 35)
HRD+ TC1 n 15 (7, 23) 0 (0, 0) 6 (3, 11) 2 (0, 4) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 4) 3 (1, 6) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.3 (0.1, 0.48) NA (NA, NA) 0.37 (0.2, 0.46) 0.4 (0.3, 0.49) NA (NA, NA) 0.43 (0.34, 0.49) NA (NA, NA) 0.4 (0.32, 0.47) 0.37 (0.2, 0.48) NA (NA, NA) 0.45 (0.39, 0.48) NA (NA, NA) 0.41 (0.41, 0.41) NA (NA, NA) NA (NA, NA) 0.4 (0.4, 0.4)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.115 (0.087, 0.181) 0.202 (0.202, 0.202) 0.125 (0.08, 0.176) 0.175 (0.089, 0.465) 0.326 (0.188, 0.464) 0.166 (0.085, 0.655) 0.114 (0.023, 0.206) 0.181 (0.084, 0.505) 0.169 (0.082, 0.591) 0.113 (0.088, 0.943) 0.138 (0, 1.605) NA (NA, NA) 0.127 (0, 0.489) NA (NA, NA) 5.852 (5.852, 5.852) 0.071 (0.014, 0.145)
HRD+ TC3 count 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96
HRD+ TC3 time 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35) 27 (20, 35)
HRD+ TC3 n 12 (6, 18) 0 (0, 0) 6 (3, 10) 2 (1, 6) 0 (0, 0) 1 (0, 3) 0 (0, 0) 2 (0, 4) 4 (2, 7) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.31 (0.09, 0.45) NA (NA, NA) 0.36 (0.17, 0.48) 0.43 (0.28, 0.49) NA (NA, NA) 0.44 (0.31, 0.48) 0.48 (0.48, 0.48) 0.44 (0.35, 0.48) 0.38 (0.23, 0.48) NA (NA, NA) 0.42 (0.39, 0.47) NA (NA, NA) 0.44 (0.44, 0.44) 0.47 (0.47, 0.47) NA (NA, NA) 0.45 (0.45, 0.45)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.118 (0.09, 0.209) 4.187 (0, 23.441) 0.128 (0.097, 0.261) 0.165 (0.084, 0.475) 0.457 (0.457, 0.457) 0.183 (0.082, 0.856) 0.089 (0, 1.611) 0.154 (0.064, 0.727) 0.131 (0.084, 0.305) NA (NA, NA) 0.162 (0, 0.381) NA (NA, NA) 0.14 (0, 0.455) 0.182 (0.135, 1.041) 0.466 (0.101, 0.841) 0.305 (0.199, 0.927)
HRD+ TC4 count 102 102 102 102 102 102 102 102 102 102 102 102 102 102 102 102
HRD+ TC4 time 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34) 30 (22, 34)
HRD+ TC4 n 12 (7, 20) 0 (0, 0) 6 (3, 11) 2 (1, 6) 0 (0, 0) 1 (0, 4) 0 (0, 0) 2 (0, 4) 4 (2, 8) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.31 (0.1, 0.47) NA (NA, NA) 0.36 (0.17, 0.48) 0.4 (0.28, 0.49) NA (NA, NA) 0.42 (0.31, 0.49) NA (NA, NA) 0.41 (0.34, 0.47) 0.35 (0.21, 0.48) NA (NA, NA) 0.44 (0.38, 0.48) 0.44 (0.44, 0.44) 0.44 (0.41, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.114 (0.085, 0.179) 0.076 (0.015, 0.216) 0.131 (0.087, 0.289) 0.146 (0.073, 0.374) 0.88 (0.204, 2.496) 0.166 (0.062, 0.586) 0.103 (0.083, 1.165) 0.166 (0.072, 0.748) 0.141 (0.085, 0.466) 0.534 (0.207, 0.867) 0.151 (0.048, 0.604) 0.313 (0.052, 0.984) 0.368 (0.107, 1.419) 0.057 (0.011, 0.061) 0.183 (0.077, 0.289) 0 (0, 0.158)
HRD+ TC5 count 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62
HRD+ TC5 time 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36) 31 (25, 36)
HRD+ TC5 n 15 (6, 24) 0 (0, 0) 6 (3, 13) 2 (0, 4) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 3) 3 (1, 6) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.29 (0.11, 0.45) 0.49 (0.49, 0.49) 0.38 (0.26, 0.48) 0.43 (0.24, 0.49) NA (NA, NA) 0.41 (0.36, 0.49) 0.49 (0.49, 0.49) 0.4 (0.3, 0.49) 0.35 (0.2, 0.48) NA (NA, NA) 0.42 (0.35, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.116 (0.087, 0.198) 0 (0, 0) 0.128 (0.091, 0.225) 0.151 (0.083, 0.505) 1.871 (1.452, 2.291) 0.21 (0.052, 0.921) 0.18 (0.036, 0.323) 0.18 (0.076, 0.42) 0.159 (0.09, 0.485) 0.071 (0.071, 0.071) 0.321 (0.1, 1.077) NA (NA, NA) 0.115 (0, 1.638) 0.17 (0.17, 0.17) 0.076 (0.015, 0.144) NA (NA, NA)
TP53+ TC1 count 182 182 182 182 182 182 182 182 182 182 182 182 182 182 182 182
TP53+ TC1 time 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34) 24 (15, 34)
TP53+ TC1 n 8 (4, 16) 6 (3, 14) 3 (1, 5) 5 (2, 12) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 0) 6 (2, 13) 4 (2, 11) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.31 (0.13, 0.46) 0.28 (0.11, 0.46) 0.4 (0.25, 0.48) 0.32 (0.15, 0.48) NA (NA, NA) 0.43 (0.31, 0.49) NA (NA, NA) 0.45 (0.34, 0.48) 0.45 (0.39, 0.49) NA (NA, NA) 0.33 (0.12, 0.46) 0.35 (0.18, 0.48) 0.47 (0.46, 0.49) NA (NA, NA) NA (NA, NA) 0.38 (0.38, 0.38)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.123 (0.083, 0.221) 0.143 (0.094, 0.298) 0.166 (0.082, 0.446) 0.143 (0.088, 0.384) 0.174 (0.035, 0.576) 0.159 (0, 0.963) 0.853 (0.171, 1.536) 0.136 (0, 0.502) 0.184 (0, 0.942) 0.315 (0.063, 0.567) 0.142 (0.092, 0.395) 0.141 (0.084, 0.46) 0.072 (0, 0.803) 0.4 (0.124, 0.727) 0.36 (0.168, 2.724) 0.071 (0.071, 0.071)
TP53+ TC3 count 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156
TP53+ TC3 time 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32)
TP53+ TC3 n 6 (3, 14) 7 (3, 13) 2 (0, 5) 4 (2, 10) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 0) 5 (2, 11) 4 (2, 10) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.32 (0.14, 0.48) 0.33 (0.14, 0.48) 0.39 (0.25, 0.48) 0.35 (0.19, 0.47) NA (NA, NA) 0.42 (0.33, 0.49) 0.46 (0.46, 0.46) 0.45 (0.33, 0.48) 0.45 (0.38, 0.49) NA (NA, NA) 0.33 (0.15, 0.47) 0.32 (0.18, 0.47) 0.44 (0.42, 0.46) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.127 (0.087, 0.252) 0.126 (0.088, 0.283) 0.174 (0.086, 0.658) 0.145 (0.094, 0.413) 0.054 (0, 0.693) 0.186 (0.045, 0.737) 0.122 (0, 2.967) 0.167 (0.049, 0.652) 0.165 (0, 0.423) 0.182 (0.017, 0.428) 0.14 (0.084, 0.311) 0.149 (0.093, 0.353) 0.129 (0, 0.769) 0.182 (0, 0.644) 0.064 (0, 0.67) 0.153 (0.044, 0.261)
TP53+ TC4 count 165 165 165 165 165 165 165 165 165 165 165 165 165 165 165 165
TP53+ TC4 time 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34)
TP53+ TC4 n 7 (4, 17) 6 (3, 16) 2 (0, 5) 4 (2, 11) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 0) 6 (2, 14) 5 (2, 9) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.31 (0.11, 0.47) 0.33 (0.14, 0.47) 0.43 (0.26, 0.49) 0.34 (0.17, 0.48) NA (NA, NA) 0.41 (0.27, 0.49) NA (NA, NA) 0.43 (0.32, 0.48) 0.44 (0.39, 0.48) NA (NA, NA) 0.35 (0.16, 0.46) 0.34 (0.16, 0.48) 0.46 (0.42, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.126 (0.086, 0.241) 0.13 (0.085, 0.27) 0.15 (0.06, 0.434) 0.147 (0.091, 0.486) 0.152 (0, 0.248) 0.16 (0.053, 0.604) 0.087 (0.014, 0.192) 0.163 (0.062, 0.701) 0.161 (0, 0.721) 0 (0, 0.373) 0.129 (0.09, 0.345) 0.149 (0.092, 0.328) 0.355 (0.026, 1.083) 0.065 (0.046, 2.579) 0 (0, 0.199) 0.565 (0.401, 0.729)
TP53+ TC5 count 177 177 177 177 177 177 177 177 177 177 177 177 177 177 177 177
TP53+ TC5 time 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34)
TP53+ TC5 n 6 (3, 15) 7 (3, 13) 2 (0, 5) 6 (3, 10) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 4 (2, 10) 4 (2, 11) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.32 (0.11, 0.47) 0.3 (0.13, 0.46) 0.41 (0.25, 0.48) 0.34 (0.14, 0.47) NA (NA, NA) 0.44 (0.31, 0.49) NA (NA, NA) 0.44 (0.29, 0.49) 0.47 (0.41, 0.5) NA (NA, NA) 0.33 (0.14, 0.47) 0.35 (0.15, 0.48) 0.45 (0.44, 0.49) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.138 (0.087, 0.301) 0.135 (0.087, 0.292) 0.159 (0.086, 0.578) 0.132 (0.08, 0.25) 0.113 (0.089, 0.211) 0.195 (0, 1.361) 0.181 (0.037, 0.298) 0.16 (0, 0.486) 0.167 (0, 0.987) 0.064 (0.013, 0.088) 0.145 (0.093, 0.432) 0.137 (0.084, 0.37) 0.079 (0, 0.78) 0 (0, 0.101) 0.076 (0, 0.572) 0.223 (0.223, 0.223)
TEfus+ TC1 count 78 78 78 78 78 78 78 78 78 78 78 78 78 78 78 78
TEfus+ TC1 time 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35) 27 (17, 35)
TEfus+ TC1 n 2 (0, 5) 3 (1, 8) 2 (1, 5) 5 (2, 11) 4 (0, 10) 1 (0, 3) 0 (0, 0) 1 (0, 3) 2 (1, 5) 2 (0, 3) 4 (2, 11) 4 (1, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.42 (0.26, 0.49) 0.35 (0.16, 0.45) 0.4 (0.26, 0.48) 0.31 (0.16, 0.47) 0.36 (0.19, 0.49) 0.42 (0.3, 0.48) NA (NA, NA) 0.44 (0.34, 0.47) 0.37 (0.24, 0.47) 0.42 (0.33, 0.47) 0.27 (0.12, 0.44) 0.35 (0.17, 0.46) 0.45 (0.36, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.147 (0.071, 0.424) 0.149 (0.099, 0.544) 0.164 (0.084, 0.5) 0.138 (0.087, 0.344) 0.132 (0.084, 0.319) 0.182 (0.077, 0.576) 0.168 (0.119, 0.217) 0.122 (0.03, 0.457) 0.168 (0.095, 0.461) 0.182 (0.055, 0.686) 0.146 (0.097, 0.488) 0.147 (0.092, 0.451) 0.191 (0, 0.618) 0.091 (0.091, 0.091) NA (NA, NA) 0.197 (0.096, 0.298)
TEfus+ TC3 count 72 72 72 72 72 72 72 72 72 72 72 72 72 72 72 72
TEfus+ TC3 time 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34)
TEfus+ TC3 n 1 (0, 4) 3 (1, 8) 2 (0, 5) 4 (2, 9) 4 (1, 9) 2 (0, 4) 0 (0, 0) 1 (0, 3) 3 (1, 5) 1 (0, 3) 5 (2, 10) 4 (2, 9) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.44 (0.29, 0.48) 0.35 (0.19, 0.48) 0.38 (0.18, 0.47) 0.34 (0.18, 0.47) 0.37 (0.16, 0.48) 0.42 (0.32, 0.48) NA (NA, NA) 0.44 (0.38, 0.48) 0.41 (0.27, 0.49) 0.42 (0.3, 0.47) 0.32 (0.14, 0.46) 0.3 (0.14, 0.47) 0.44 (0.41, 0.48) NA (NA, NA) NA (NA, NA) 0.41 (0.41, 0.41)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.169 (0.078, 0.569) 0.159 (0.094, 0.443) 0.183 (0.096, 0.515) 0.157 (0.097, 0.413) 0.141 (0.084, 0.295) 0.17 (0.077, 0.505) 0 (0, 0) 0.168 (0.059, 0.751) 0.133 (0.075, 0.358) 0.156 (0.052, 0.388) 0.133 (0.084, 0.277) 0.159 (0.093, 0.39) 0.194 (0, 0.733) 0.122 (0.122, 0.122) 0.138 (0.028, 0.655) 0.305 (0.188, 0.927)
TEfus+ TC4 count 69 69 69 69 69 69 69 69 69 69 69 69 69 69 69 69
TEfus+ TC4 time 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35)
TEfus+ TC4 n 1 (0, 4) 3 (1, 8) 2 (0, 5) 4 (2, 8) 4 (2, 7) 2 (0, 5) 0 (0, 0) 1 (0, 3) 2 (1, 6) 1 (0, 3) 6 (2, 14) 4 (1, 7) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.43 (0.32, 0.48) 0.37 (0.24, 0.46) 0.41 (0.3, 0.48) 0.35 (0.18, 0.48) 0.38 (0.22, 0.48) 0.42 (0.28, 0.49) NA (NA, NA) 0.44 (0.37, 0.49) 0.39 (0.26, 0.48) 0.43 (0.31, 0.49) 0.33 (0.15, 0.47) 0.32 (0.17, 0.46) 0.46 (0.4, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.201 (0.102, 1.069) 0.144 (0.088, 0.933) 0.156 (0.096, 0.47) 0.13 (0.079, 0.378) 0.146 (0.076, 0.407) 0.148 (0.059, 0.366) NA (NA, NA) 0.174 (0.076, 0.539) 0.165 (0.073, 0.862) 0.162 (0.073, 0.59) 0.122 (0.084, 0.297) 0.169 (0.1, 0.476) 0.121 (0, 0.245) 0.2 (0.109, 0.29) 0.112 (0.022, 0.275) 0.385 (0.077, 0.693)
TEfus+ TC5 count 92 92 92 92 92 92 92 92 92 92 92 92 92 92 92 92
TEfus+ TC5 time 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35) 24 (17, 35)
TEfus+ TC5 n 1 (0, 4) 4 (2, 7) 2 (0, 4) 6 (3, 10) 3 (1, 9) 1 (0, 4) 0 (0, 0) 0 (0, 2) 2 (1, 5) 1 (0, 3) 5 (2, 11) 4 (3, 10) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.41 (0.3, 0.47) 0.32 (0.18, 0.47) 0.41 (0.28, 0.48) 0.31 (0.15, 0.46) 0.38 (0.23, 0.47) 0.44 (0.3, 0.48) NA (NA, NA) 0.44 (0.31, 0.49) 0.39 (0.21, 0.48) 0.41 (0.33, 0.47) 0.33 (0.13, 0.46) 0.32 (0.13, 0.44) 0.46 (0.41, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0.186 (0.092, 0.849) 0.163 (0.09, 0.457) 0.16 (0.091, 0.813) 0.131 (0.09, 0.268) 0.189 (0.096, 0.788) 0.138 (0.077, 0.484) 0.222 (0.142, 0.302) 0.177 (0, 0.44) 0.195 (0.089, 0.625) 0.264 (0.067, 1.577) 0.128 (0.087, 0.377) 0.144 (0.096, 0.283) 0.109 (0, 0.887) NA (NA, NA) 0.076 (0.076, 0.076) NA (NA, NA)
PI3K+ TC1 count 125 125 125 125 125 125 125 125 125 125 125 125 125 125 125 125
PI3K+ TC1 time 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35)
PI3K+ TC1 n 7 (3, 21) 4 (1, 9) 7 (3, 14) 6 (3, 12) 0 (0, 0) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 2) 1 (0, 4) 0 (0, 0) 5 (1, 11) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.28 (0.11, 0.46) 0.36 (0.18, 0.47) 0.26 (0.13, 0.46) 0.33 (0.15, 0.45) NA (NA, NA) 0.42 (0.29, 0.49) 0.45 (0.33, 0.49) 0.44 (0.34, 0.48) 0.42 (0.35, 0.48) 0.43 (0.31, 0.48) NA (NA, NA) 0.33 (0.17, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.128 (0.085, 0.227) 0.156 (0.081, 0.388) 0.135 (0.09, 0.3) 0.136 (0.094, 0.319) 20.482 (20.482, 20.482) 0.159 (0.049, 0.653) 0.196 (0, 1.187) 0.162 (0.053, 1.088) 0.205 (0, 0.695) 0.163 (0.055, 0.73) 0.044 (0.009, 0.079) 0.143 (0.086, 0.421) 0 (0, 0.449) 0.046 (0.009, 0.082) 0.498 (0.391, 0.606) 0.095 (0.019, 0.172)
PI3K+ TC3 count 113 113 113 113 113 113 113 113 113 113 113 113 113 113 113 113
PI3K+ TC3 time 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34)
PI3K+ TC3 n 7 (2, 18) 4 (1, 9) 7 (3, 15) 5 (2, 10) 0 (0, 0) 2 (0, 4) 1 (0, 3) 1 (0, 4) 1 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.3 (0.1, 0.45) 0.33 (0.18, 0.46) 0.3 (0.13, 0.46) 0.35 (0.16, 0.48) NA (NA, NA) 0.41 (0.29, 0.47) 0.42 (0.3, 0.48) 0.44 (0.35, 0.49) 0.45 (0.36, 0.49) 0.42 (0.32, 0.48) NA (NA, NA) 0.32 (0.18, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.13 (0.095, 0.332) 0.154 (0.103, 0.466) 0.132 (0.088, 0.271) 0.142 (0.085, 0.33) 0.202 (0.123, 0.454) 0.164 (0.083, 0.433) 0.183 (0.066, 0.716) 0.147 (0.054, 0.438) 0.133 (0, 0.659) 0.188 (0.03, 0.594) 0.182 (0.017, 0.428) 0.148 (0.093, 0.384) NA (NA, NA) 0.168 (0.168, 0.168) 0.152 (0.129, 0.176) 1.082 (1.082, 1.082)
PI3K+ TC4 count 122 122 122 122 122 122 122 122 122 122 122 122 122 122 122 122
PI3K+ TC4 time 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35)
PI3K+ TC4 n 7 (3, 22) 4 (1, 10) 6 (3, 14) 5 (2, 10) 0 (0, 0) 2 (1, 5) 1 (0, 3) 1 (0, 3) 1 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.3 (0.13, 0.46) 0.39 (0.21, 0.48) 0.33 (0.13, 0.45) 0.34 (0.15, 0.47) NA (NA, NA) 0.41 (0.28, 0.49) 0.42 (0.3, 0.49) 0.42 (0.3, 0.48) 0.43 (0.36, 0.47) 0.41 (0.33, 0.48) NA (NA, NA) 0.33 (0.16, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.128 (0.088, 0.342) 0.144 (0.084, 0.339) 0.13 (0.095, 0.257) 0.143 (0.09, 0.469) 0.164 (0, 0.287) 0.162 (0.073, 0.674) 0.177 (0.065, 0.631) 0.165 (0.065, 0.731) 0.234 (0.055, 1.522) 0.164 (0.073, 0.581) 0 (0, 0.105) 0.154 (0.095, 0.384) 0.415 (0.116, 0.704) 0.34 (0.154, 0.828) 0 (0, 3.375) 0.565 (0.345, 1.318)
PI3K+ TC5 count 172 172 172 172 172 172 172 172 172 172 172 172 172 172 172 172
PI3K+ TC5 time 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33) 19 (10, 33)
PI3K+ TC5 n 8 (5, 16) 4 (2, 9) 7 (3, 13) 6 (3, 10) 0 (0, 0) 1 (0, 4) 0 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 4) 0 (0, 0) 4 (2, 11) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.29 (0.09, 0.46) 0.37 (0.17, 0.47) 0.31 (0.13, 0.48) 0.34 (0.15, 0.47) 0.46 (0.45, 0.48) 0.43 (0.32, 0.49) 0.44 (0.31, 0.49) 0.44 (0.33, 0.49) 0.44 (0.38, 0.49) 0.44 (0.31, 0.47) NA (NA, NA) 0.36 (0.19, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.127 (0.088, 0.219) 0.149 (0.081, 0.444) 0.126 (0.085, 0.315) 0.131 (0.082, 0.243) 1.136 (0.227, 2.045) 0.165 (0.085, 0.567) 0.213 (0, 1.321) 0.139 (0, 0.413) 0.15 (0, 0.593) 0.217 (0.06, 1.093) 0.145 (0, 0.648) 0.144 (0.084, 0.296) 0.071 (0.014, 0.192) 0 (0, 0) NA (NA, NA) 0.174 (0.135, 0.213)